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Table 4 Genes with increased methylation that mapped to the regulation of the EMT pathway by IPA

From: Association of aberrant DNA methylation in Apcmin/+ mice with the epithelial-mesenchymal transition and Wnt/β-catenin pathways: genome-wide analysis using MeDIP-seq

Symbol Gene name log2 Fold Change Location Type(s)
SMAD3 SMAD family member 3 3.877 Nucleus transcription regulator
JAG1 jagged 1 3.614 Extracellular Space growth factor
WNT5A wingless-type MMTV integration site family, member 5A 3.292 Extracellular Space cytokine
FGF13 fibroblast growth factor 13 3.100 Extracellular Space growth factor
WNT10A wingless-type MMTV integration site family, member 10A 3.100 Extracellular Space other
EGFR epidermal growth factor receptor 2.877 Plasma Membrane kinase
FGF7 fibroblast growth factor 7 2.877 Extracellular Space growth factor
FGF14 fibroblast growth factor 14 2.877 Extracellular Space growth factor
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 2.877 Nucleus transcription regulator
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 2.877 Cytoplasm kinase
FZD1 frizzled class receptor 1 2.752 Plasma Membrane G-protein coupled receptor
CDH12 cadherin 12, type 2 (N-cadherin 2) 2.614 Plasma Membrane other
FGF8 fibroblast growth factor 8 (androgen-induced) 2.614 Extracellular Space growth factor
FZD8 frizzled class receptor 8 2.614 Plasma Membrane G-protein coupled receptor
JAK2 Janus kinase 2 2.614 Cytoplasm kinase
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma 2.614 Cytoplasm kinase
ZEB1 zinc finger E-box binding homeobox 1 2.614 Nucleus transcription regulator
GSC goosecoid homeobox 2.462 Nucleus transcription regulator
ADAM17 ADAM metallopeptidase domain 17 2.292 Plasma Membrane peptidase
FGF9 fibroblast growth factor 9 2.292 Extracellular Space growth factor
FGF11 fibroblast growth factor 11 2.292 Extracellular Space growth factor
FGFR2 fibroblast growth factor receptor 2 2.292 Plasma Membrane kinase
FRS2 fibroblast growth factor receptor substrate 2 2.292 Plasma Membrane other
GRB2 growth factor receptor-bound protein 2 2.292 Cytoplasm other
LOX lysyl oxidase 2.292 Extracellular Space enzyme
NCSTN nicastrin 2.292 Plasma Membrane peptidase
PARD6B par-6 family cell polarity regulator beta 2.292 Plasma Membrane other
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 2.292 Cytoplasm kinase
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 2.292 Cytoplasm kinase
SOS2 son of sevenless homolog 2 (Drosophila) 2.292 Cytoplasm other
TGFB2 transforming growth factor, beta 2 2.292 Extracellular Space growth factor
WNT2 wingless-type MMTV integration site family member 2 2.292 Extracellular Space cytokine
MET MET proto-oncogene, receptor tyrosine kinase 2.180 Plasma Membrane kinase
AKT3 v-akt murine thymoma viral oncogene homolog 3 2.100 Cytoplasm kinase
TWIST2 twist family bHLH transcription factor 2 2.100 Nucleus transcription regulator
WNT2B wingless-type MMTV integration site family, member 2B 2.100 Extracellular Space other
WNT16 wingless-type MMTV integration site family, member 16 2.029 Extracellular Space other