Table 4 Genes with increased methylation that mapped to the regulation of the EMT pathway by IPA
Symbol | Gene name | log2 Fold Change | Location | Type(s) |
|---|---|---|---|---|
SMAD3 | SMAD family member 3 | 3.877 | Nucleus | transcription regulator |
JAG1 | jagged 1 | 3.614 | Extracellular Space | growth factor |
WNT5A | wingless-type MMTV integration site family, member 5A | 3.292 | Extracellular Space | cytokine |
FGF13 | fibroblast growth factor 13 | 3.100 | Extracellular Space | growth factor |
WNT10A | wingless-type MMTV integration site family, member 10A | 3.100 | Extracellular Space | other |
EGFR | epidermal growth factor receptor | 2.877 | Plasma Membrane | kinase |
FGF7 | fibroblast growth factor 7 | 2.877 | Extracellular Space | growth factor |
FGF14 | fibroblast growth factor 14 | 2.877 | Extracellular Space | growth factor |
ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 2.877 | Nucleus | transcription regulator |
PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 2.877 | Cytoplasm | kinase |
FZD1 | frizzled class receptor 1 | 2.752 | Plasma Membrane | G-protein coupled receptor |
CDH12 | cadherin 12, type 2 (N-cadherin 2) | 2.614 | Plasma Membrane | other |
FGF8 | fibroblast growth factor 8 (androgen-induced) | 2.614 | Extracellular Space | growth factor |
FZD8 | frizzled class receptor 8 | 2.614 | Plasma Membrane | G-protein coupled receptor |
JAK2 | Janus kinase 2 | 2.614 | Cytoplasm | kinase |
PIK3C2G | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma | 2.614 | Cytoplasm | kinase |
ZEB1 | zinc finger E-box binding homeobox 1 | 2.614 | Nucleus | transcription regulator |
GSC | goosecoid homeobox | 2.462 | Nucleus | transcription regulator |
ADAM17 | ADAM metallopeptidase domain 17 | 2.292 | Plasma Membrane | peptidase |
FGF9 | fibroblast growth factor 9 | 2.292 | Extracellular Space | growth factor |
FGF11 | fibroblast growth factor 11 | 2.292 | Extracellular Space | growth factor |
FGFR2 | fibroblast growth factor receptor 2 | 2.292 | Plasma Membrane | kinase |
FRS2 | fibroblast growth factor receptor substrate 2 | 2.292 | Plasma Membrane | other |
GRB2 | growth factor receptor-bound protein 2 | 2.292 | Cytoplasm | other |
LOX | lysyl oxidase | 2.292 | Extracellular Space | enzyme |
NCSTN | nicastrin | 2.292 | Plasma Membrane | peptidase |
PARD6B | par-6 family cell polarity regulator beta | 2.292 | Plasma Membrane | other |
PIK3CG | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma | 2.292 | Cytoplasm | kinase |
PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 2.292 | Cytoplasm | kinase |
SOS2 | son of sevenless homolog 2 (Drosophila) | 2.292 | Cytoplasm | other |
TGFB2 | transforming growth factor, beta 2 | 2.292 | Extracellular Space | growth factor |
WNT2 | wingless-type MMTV integration site family member 2 | 2.292 | Extracellular Space | cytokine |
MET | MET proto-oncogene, receptor tyrosine kinase | 2.180 | Plasma Membrane | kinase |
AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 2.100 | Cytoplasm | kinase |
TWIST2 | twist family bHLH transcription factor 2 | 2.100 | Nucleus | transcription regulator |
WNT2B | wingless-type MMTV integration site family, member 2B | 2.100 | Extracellular Space | other |
WNT16 | wingless-type MMTV integration site family, member 16 | 2.029 | Extracellular Space | other |