Skip to main content
Figure 1 | Cell & Bioscience

Figure 1

From: Induction of the intrinsic apoptotic pathway via a new antimitotic agent in an esophageal carcinoma cell line

Figure 1

Structural comparison between (A) 2ME and (B) ESE-16. When the two chemical structures are compared, an exchange of a sulphamoylated group for a hydroxyl group at position 3 and the removal of a hydroxyl group at position 17 on the ESE-16 compound are noticed. The sulphamoylated group increases the bioavailability of the compound [8, 13, 20, 28, 29], while the modifications at position 3 and −17 increases the anticancer potency and provides a prolonged half-life [6, 11, 13, 22, 27, 28].

Back to article page

Cell & Bioscience

ISSN: 2045-3701

Contact us