Figure 2From: Interleukin-6 is required for cell cycle arrest and activation of DNA repair enzymes after partial hepatectomy in miceOxidative DNA damage in the remaining liver after PH. (A) The gross morphological changes after 70% PH. There is no difference between WT and IL-6 KO mice on day 1 and day 2 after PH. However, on day 3 after PH, IL-6 KO livers show pale-yellowish color and the liver size did not increase. In contrast, the WT liver increased in size and had a normal color. Representative photographs of n = 3 individual samples per group. (B) H&E staining demonstrated that necrosis appeared in liver tissue sections recovered from IL-6 KO mice at 48 and 72 hours after PH in IL-6 KO mice. No necrosis/apoptosis appeared in liver sections from WT mice after PH. (C) Levels of 8-OHdG in DNA of the remaining liver after PH. Data represent mean ± SEM (n = 3). n.s., no significant difference. *P < 0.05.Back to article page