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Table 2 Immunohistochemical stain results and clinicopathologic features in peritumoral tissue of 120 HCCs

From: Proliferative ductular reactions correlate with hepatic progenitor cell and predict recurrence in HCC patients after curative resection

Clinicopathologic features Peritumoral EpCAM density P Value Peritumral OV6 density P Value Peritumral CD133 density P Value Peritumral c-kit density P Value
High Low High Low High Low High Low
Frequency (%) 40 (33.3%) 80 (66.7%)   34 (28.3%) 86 (71.7%)   33 (27.5%) 87 (72.5%)   39 (32.5%) 81 (67.5%)  
Gender             
Male 35 73 0.747 30 78 0.946 30 78 1.000 37 71 0.363
Female 5 7   4 8   3 9   2 10  
Age             
≤50 21 42 1.000 16 47 0.453 19 44 0.493 20 43 0.853
>50 19 38   18 39   14 43   19 38  
AFP             
≤400 25 56 0..408 22 59 0.681 23 58 0.752 24 57 0.333
>400 15 24   12 27   10 29   15 24  
Cirrhosis             
Absence 20 51 0.149 19 52 0.645 17 54 0.294 17 54 0.016*
Presence 20 29   15 34   16 33   22 27  
Satellite lesion             
Absence 36 69 0.770 28 77 0.284 29 76 1.000 35 70 0.606
Presence 4 11   6 9   4 11   4 11  
Tumor size (cm)             
≤5cm 15 37 0.362 15 37 0.913 16 36 0.483 18 34 0.665
>5cm 25 43   19 49   17 51   21 47  
Tumor encapsulation             
Absence 26 61 0.193 26 61 0.540 23 64 0.672 27 60 0.578
Presence 14 19   8 25   10 23   12 21  
Microvascular invasion             
Absence 17 38 0.604 17 38 0.565 18 37 0.238 22 33 0.107
Presence 23 42   17 48   15 50   17 48  
Major vascular invasion             
Absence 39 75 0.657 33 81 0.853 29 85 0.083 38 76 0.687
Presence 1 5   1 5   4 2   1 5  
Edmondson grade             
Low (I/II) 27 63 0.180 21 69 0.035* 23 67 0.409 28 62 0.574
High (III/IV) 13 17   13 17   10 20   11 19  
TNM stage             
I/II 25 67 0.009* 23 69 0.142 16 76 <0.001* 29 63 0.678
III 15 13   11 17   17 11   10 18  
  1. *p <0 .05 was considered statistically significant.