The inhibitory effect of pinocembrin on TGF-β1-induced integrin levels in Y-79 cells. (A) Cells were pretreated with TGF-β1 (10 ng/ml) and then incubated in the different concentrations of pinocembrin (0, 1, 2.5, and 5 μM) for 6 h, and the integrins were analyzed. (B) Cells were pretreated with TGF-β1 (10 ng/ml) and then incubated in 5 μM pinocembrin for different lengths of time (0, 30, 60, 120, and 180 mins), and then the integrins were analyzed. (C) The expressions of integrins were determined by flowcytometry. Values are expressed as mean ± SD of three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001 compared with the 0 h-treated time.