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Table 2 Chemokines in tumor microenvironment and effects on tumor progression

From: One cell, multiple roles: contribution of mesenchymal stem cells to tumor development in tumor microenvironment

Chemokines Chemokine receptors Cellular sources Tumor growth Metastasis Immune response References
CCL2 CCR2 tumor cells, macrophages, endothelial cells, TAFs +(low concentration) + - [4246]
-(high concentration)
CCL3 CCR1,4,5 endothelial cells + + + [42, 47]
CCL4 CCR5 macrophages + + - [42]
CCL5 CCR1,3,5 MSCs, tumor cells, TAFs + +   [42, 48]
CCL7 CCR1,2,3   + +   [42]
CCL8 CCR2,3,5   + +   [42]
CCL11 CCR3   + +   [42]
CCL12 CCR2   + +   [42]
CCL16 CCR1   - -   [49]
CCL17 CCR4 tumor cells, macrophages - + + [42, 50]
CCL18 unknown TAM   +   [42, 51]
CCL19 CCR7,11 tumor cells, DCs + + [42, 52]
CCL20 CCR6 tumor cells - + + [5356]
CCL21 CCR7,11 lymph nodes, tumor cells, endothelial cells - +   [5764]
CCL22 CCR4 tumor cells, macrophages - + + [42, 50, 65]
CCL23 CCR1   + +   [42]
CCL24 CCR3   + +   [42]
CCL25 CCR9,11   + +   [42]
CCL26 CCR3   + +   [42]
CCL27 CCR2,3,10   + +   [66]
CXCL1 CXCR1,2 tumor cells, TAFs + -   [59, 67, 68]
CXCL2 CXCR2 tumor cells, TAFs + +   [42, 6770]
CXCL3(GRO-α,β,γ) CXCR2 tumor cells, TAFs + -   [67, 68, 71]
CXCL5( ENA-78) CXCR1,2   + +   [42, 71, 72]
CXCL6 CXCR1,2   + +   [42]
CXCL7(NAP2) CXCR1,2   + +   [42]
CXCL8 CXCR1,2 TAFs,endothelial cells, tumor cells, monocytes + +   [19, 42, 59, 7376]
CXCL9 CXCR3   -    [77, 78]
CXCL10 CXCR3 tumor cells -    [59, 78]
CXCL11 CXCR3   -    [61, 7982]
CXCL12 CXCR4 tumor cells, astrocytes, fibroblasts, microglia cells + +   [61, 8386]
CXCL13 CXCR5 tumor cells, macrophages,TAFs + +   [42, 8789]
CXCL14 unknown   -   + [90]
CX3CL1 CX3CR1   + +   [9195]
PF4    -    [96, 97]
IP-10 CXCR3   -    [38, 71, 80, 98]
MIG CXCR3   - -   [71, 99]
  1. Abbreviations: +, promote; —, inhibit.