Table 2 Dynamic changes of cytokines after bone marrow-derived stem cells (BMSCs) transplantation
From: Bone marrow-derived stem cells ameliorate hepatic fibrosis by down-regulating interleukin-17
Cytokines | HC | Weeks after BMSCs transplantation | |||||
|---|---|---|---|---|---|---|---|
Baseline | 4w | 12w | 24w | 36w | 48w | ||
TNF-α | 1.8(1.2) | 36.2(7.6)a | 34.1(12.3) | 38.3(9.2) | 32.4(5.3) | 31.6(2.5) | 32.5(5.7) |
IFN-γ | 3.0(1.1) | 2.0(0.8) | 4.5(1.3) | 1.0(0.7) | 1.7(0.8) | 2.6(0.4) | 3.7(1.1) |
IL-12 | 3.2(0.6) | 23.2(1.4)a | 21.4(2.1) | 18.9(1.7) | 20.1(2.2) | 19.6(1.5) | 20.5(1.2) |
IL-13 | 5.6(1.4) | 5.7(2.0) | 6.1(1.2) | 7.5(2.1) | 6.0(1.5) | 5.8(1.2) | 5.7(1.5) |
TGF-β1 | 8.9(1.3) | 23.4(8.3)a | 26.5(7.6) | 18.2(6.2) | 21.6(3.7) | 19.5(9.1) | 22.2(4.3) |
IL-17 | 21.2(18.9) | 216.4(109.3)a | 269.8(112.4) | 189.0(108.2) | 106.1(92.3)b | 118.2(102.9)b | 57.0(32.7)b |
IL-8 | 17.2(10.3) | 131.4(59.3)a | 142.9(71.5) | 129.3(50.2) | 150.2(48.2) | 136.5(32.7) | 132.4(70.2) |