Skip to main content

Advertisement

Table 1 Developmental and reproductive anomalies associated with p53 loss

From: Embryonic stem cells shed new light on the developmental roles of p53

Anomalies Stage Stress Background Molecular References
     mechanism  
Implantation failure Pre-implantation Physiological C57BL/6 J (more severe), 129/Sv and Mix p53 regulates Lif Hu, et al., Nature, 2007
Exencephaly Embryonic Physiological 129 (more severe), C57BL/6 Unclear Armstrong, et al., Curr. Biol., 1995; Sah, et al., Nature Genetics, 1995
Renal hypoplasia Embryonic Physiological C57BL/6 p53 regulates Pax2 Saifudeen, et al., Plos One, 2012
Polydactyly, megadactyly Fetuses X-ray 129/SvJ Unclear Norimura, et al., Nature Medicine, 1996
Tail anomaly Fetuses X-ray 129/SvJ Unclear Norimura, et al., Nature Medicine, 1996
Muscle Adult Physiological Unknown Unclear Molchadsky, et al., Plos One, 2008
Testis Adult Physiological 129 (100% penetrance), C57BL/6X129 mix background is normal Unclear Rotter, et al., PNAS, 1993