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Figure 1 | Cell & Bioscience

Figure 1

From: TGF-beta1 on osteoimmunology and the bone component cells

Figure 1

Five major role of TGF-β1 in osteoimmunity are shown. (1) TGF-β1 stimulates the proliferation of MSCs, and promotes their differentiation into chondrocytes. (2) TGF-β1 promotes osteoblast progenitor’s differentiation into osteoblast. (3) High concentration of TGF-β1 enhances osteoblast proliferation, and downregulates the expression of RANKL of osteoblast. (4) Low concentration of TGF-β1 promoted osteoclast maturation. (5) TGF-β keeps hematopoietic stem cells (HSC) in hibernation state.

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