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Figure 3 | Cell & Bioscience

Figure 3

From: Radioprotective effects of oral 17-dimethylaminoethylamino-17-demethoxygeldanamycin in mice: bone marrow and small intestine

Figure 3

17-DMAG attenuated body weight loss and promoted recovery of reduced water consumption as well as facial dropsy. Mice were orally administered with 10 mg/kg 17-DMAG or vehicle 24 h prior to irradiation at 8.75 Gy (N = 16 mice per group). Their body weights and facial dropsy were monitored for 30 days. Water consumption was measured daily for the first 7 days. (A) Attenuation of body-weight loss during days 15 to 30 after irradiation, * p = 0.03 vs. Veh/RI. Error bars indicate the standard error of the mean (SEM) for 5−16 mice per group at different days. (B) Improvement of water consumption at days 1, 3, 5, and 6 during the first 7 days after irradiation, * p = 0.03 vs. Veh/RI group. Error bars indicate the standard error of the SEM for 16 mice per group at different days. (C) Murine facial area at days 5, 10, 15, and 20 after irradiation. At day 10, * p < 0.01 vs. Veh/sham and 17-D/sham, and error bars indicate the SEM for 13−16 mice per group; at day 15, * p < 0.01 vs. Veh/sham, 17-D/sham, and 17-D/RI; ** p < 0.001 vs. Veh/RI, error bars indicate the SEM for 9−16 mice per group. Veh: vehicle; 17-D: 17-DMAG; RI: radiation injury.

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