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Figure 3 | Cell & Bioscience

Figure 3

From: Specific structure and unique function define the hemicentin

Figure 3

Schematic representation of hemicentin (Red) and non-muscle myosin IIB / actin (Green) predicted migration during mitosis. (A) Extracellular hemicentin and intracellular myosin this & actin localization during contractile ring complex formation—from G-phase to metaphase and extending into cytokinesis. During G-phase, cytoplasmic myosin and actin begin congregating on the internal cell surface to form the contractile ring. Simultaneously, the extracellular, membrane bound hemicentin travel from their previously homogeneous distribution to localize in the cleavage furrow. By metaphase, this process results in an open ring composed of a solid weave of intracellular myosin and actin held in place by hemicentin studding the band extracellularly. This contractile ring then shrinks during cytokinesis with hemicentin serving as anchor points of contraction. When cell division is complete, all molecules return once again to their previous even distribution. (B) Artistic 3 dimensional rendering of the dynamic process describing an open ring contracting over time.

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