Glucocorticoids promote lipolysis in adipocytes. Glucocorticoids (GC) activate the transcription of Lipe, Mgll, and Angptl4 gene transcription. Lipe and Mgll encode enzymes in the lipolytic pathway. Angptl4 is a secreted protein that likely binds to an unknown receptor to increase cAMP levels in adipocytes, which in turn activates PKA. PKA phosphorylates Lipe, which increases its activity and translocation from cytosol to lipid droplet. GC also increase the expression of Pnpla2 and decrease the expression of Pde3b. The mechanisms for these events are unknown (dashed line).