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Figure 7 | Cell & Bioscience

Figure 7

From: 17-DMAG diminishes hemorrhage-induced small intestine injury by elevating Bcl-2 protein and inhibiting iNOS pathway, TNF-α increase, and caspase-3 activation

Figure 7

17-DMAG treatment inhibits hemorrhage-induced injury in jejunum. Mice were treated with 10 mg/kg 17-DMAG 16 hr prior to hemorrhage. After hemorrhage mice were allowed to respond for 6 hr before sample collection. (n = 4-5 per group). (A-D) Representative histology slides from jejunum of mice treated with VEH, VEH+HEMO, 17-DMAG, or 17-DMAG+HEMO. (E) Villus height measurements after treatments. *P < 0.05 vs. VEH, 17-D, and 17-D+HE; **P < 0.05 vs. VEH, VEH+HE, and 17-D. (F) Villus width measurements after treatments. *P < 0.05 vs. VEH, 17-D, and 17-D+HE. (G) Crypt depth measurements after treatments. *P < 0.05 vs. VEH, 17-D, and 17-D+HE. (H) Mucosal damage assessments. *P < 0.05 vs. VEH, 17-D, and 17-D+HE. VEH: vehicle; HE or HEMO: hemorrhage; 17-D: 17-DMAG

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