TIMP-1-/- mice are more susceptible to CCl
-induced acute liver injury. A, B, Wild-type and TIMP-1-/- mice were treated with CCl4 for 12 or 24 hours. Serum ALT levels were assayed (A). The liver tissue sections were stained with H&E. Representative pictures are shown (original magnification × 100) (B). C, D, TUNEL positive hepatocytes were counted (C) and representative pictures of TUNEL staining are shown (D). Values represent means ± SEM (n = 6-10) *P < 0.05.