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Table 1a National incidence of variant subtypes of congenital heart defects in China during 2011–2013 (CI 95%)

From: Incidence, distribution, disease spectrum, and genetic deficits of congenital heart defects in China: implementation of prenatal ultrasound screening identified 18,171 affected fetuses from 2,452,249 pregnancies

Disease

Geographical area

Hospital level

 

North

Central

East

South

Northwest

Southwest

National

Tertiary

Primary/Secondary

Major

         

TOF

9·03

10

12·34

8·42

5·6

7·97

9·72

9·04

0·69

(7·92–10·20)

(9·44–10·58)

(11·30–13·44)

(7·25–9·67)

(4·36–7·00)

(6·91–9·12)

(9·34–10·12)

(8·66–9·42)

(0·59–0·79)

AVSD

5·73

8·11

6·68

7·97

4·95

6·69

7·29

6·78

0·51

(4·86–6·67)

(7·60–8·63)

(5·91–7·49)

(6·84–9·18)

(3·79–6·27)

(5·72–7·75)

(6·96–7·63)

(6·46–7·11)

(0·42–0·60)

DORV

3·78

5·71

4·65

6·12

3·82

4·01

5·09

4·85

0·24

(3·08–4·56)

(5·28–6·15)

(4·02–5·33)

(5·14–7·19)

(2·80–4·99)

(3·26–4·83)

(4·81–5·38)

(4·58–5·13)

(0·18–0·30)

TGA

2·85

3·69

4·72

4·37

2·76

4·01

3·82

3·6

0·22

(2·24–3·52)

(3·35–4·05)

(4·09–5·41)

(3·54–5·28)

(1·91–3·77)

(3·26–4·83)

(3·58–4·07)

(3·36–3·84)

(0·17–0·29)

SV

1·65

3·79

0·75

4·46

2·52

5·33

3·19

3·01

0·18

(1·20–2·17)

(3·44–4·15)

(0·51–1·03)

(3·62–5·38)

(1·71–3·48)

(4·46–6·27)

(2·97–3·42)

(2·8–3·23)

(0·13–0·24)

HLHS

2·4

2·66

3·54

2·66

2·03

3·41

2·83

2·7

0·13

(1·85–3·02)

(2·38–2·97)

(2·99–4·14)

(2·02–3·38)

(1·31–2·90)

(2·72–4·17)

(2·62–3·04)

(2·5–2·91)

(0·09–0·17)

PTA

3·37

2·57

2·15

2·57

2·44

3·89

2·71

2·55

0·16

(2·71–4·10)

(2·29–2·87)

(1·72–2·61)

(1·94–3·28)

(1·64–3·39)

(3·15–4·70)

(2·51–2·92)

(2·35–2·75)

(0·12–0·22)

HRHS

1·12

2·24

2·15

2·66

1·14

2·4

2·1

2

0·1

(0·76–1·56)

(1·98–2·52)

(1·72–2·61)

(2·02–3·38)

(0·62–1·81)

(1·84–3·05)

(1·92–2·29)

(1·83–2·18)

(0·06–0·14)

HS

1·2

2·03

2·19

2·07

0·81

1·0

1·81

1·72

0·09

(0·82–1·65)

(1·78–2·30)

(1·77–2·67)

(1·52–2·71)

(0·39–1·39)

(0·65–1·43)

(1·64–1·98)

(1·56–1·88)

(0·06–0·13)

PA

0·07

0·7

0·72

0·68

0·24

0·24

0·56

0·55

0·01

(0·01–0·22)

(0·55–0·86)

(0·49–1·01)

(0·38–1·06)

(0·05–0·60)

(0·09–0·47)

(0·47–0·66)

(0·46–0·65)

(0·00–0·03)

Other major*

0·41

0·62

1·01

0·95

0·57

1·2

0·75

0·68

0·07

(0·21–0·69)

(0·49–0·77)

(0·73–1·34)

(0·58–1·39)

(0·23–1·07)

(0·81–1·67)

(0·65–0·86)

(0·58–0·78)

(0·04–0·11)

Minor

         

VSD

11·57

19·31

20·59

14·31

8·85

19·44

17·72

17·04

0·68

(10·32–12·9)

(18·52–20·11)

(19·23–21·99)

(12·78–15·93)

(7·27–10·59)

(17·75–21·20)

(17·20–18·25)

(16·53–17·56)

(0·58–0·78)

PLSVC

3·26

4·22

3·83

9·05

2·11

2·77

4·23

3·84

0·4

(2·61–3·98)

(3·86–4·60)

(3·26–4·45)

(7·84–10·34)

(1·38–3·00)

(2·15–3·46)

(3·98–4·49)

(3·6–4·09)

(0·32–0·48)

COA/IAA

1·42

2·75

2·53

4·64

2·52

2·64

2·72

2·6

0·11

(1·01–1·91)

(2·46–3·06)

(2·07–3·04)

(3·78–5·58)

(1·71–3·48)

(2·05–3·32)

(2·51–2·93)

(2·40–2·81)

(0·08–0·16)

AS

2·4

1·5

2·43

2·25

1·06

2·48

1·9

1·81

0·09

(1·85–3·02)

(1·28–1·73)

(1·98–2·93)

(1·67–2·92)

(0·56–1·71)

(1·91–3·14)

(1·73–2·08)

(1·65–1·99)

(0·05–0·13)

PS

1·2

1·86

2·22

1·8

1·38

1·76

1·81

1·67

0·14

(0·82–1·65)

(1·62–2·12)

(1·79–2·69)

(1·29–2·40)

(0·80–2·12)

(1·28–2·32)

(1·65–1·98)

(1·51–1·83)

(0·10–0·19)

CVR

0·6

2·25

0·63

1·76

0·41

1·32

1·57

1·43

0·14

(0·34–0·93)

(1·99–2·53)

(0·41–0·89)

(1·25–2·35)

(0·13–0·84)

(0·91–1·81)

(1·41–1·73)

(1·28–1·58)

(0·10–0·19)

Rhabdomyoma

1·09

1·17

1·04

1·62

1·06

1·56

1·21

1·13

0·09

(0·73–1·52)

(0·98–1·37)

(0·75–1·37)

(1·14–2·19)

(0·56–1·71)

(1·11–2·09)

(1·08–1·35)

(1·00–1·26)

(0·05–0·13)

RAA

1·84

0·53

0·84

1·94

1·38

1·52

1·0

0·94

0·06

(1·36–2·39)

(0·40–0·67)

(0·59–1·15)

(1·40–2·56)

(0·80–2·12)

(1·08–2·05)

(0·87–1·12)

(0·82–1·06)

(0·03–0·09)

TVS

0·56

1·16

0·48

0·45

0·81

0·56

0·84

0·8

0·04

(0·31–0·88)

(0·97–1·36)

(0·29–0·72)

(0·21–0·77)

(0·39–1·39)

(0·31–0·89)

(0·73–0·95)

(0·69–0·91)

(0·02–0·07)

EA

0·37

0·61

0·31

0·41

0·49

0·64

0·51

0·5

0·01

(0·18–0·64)

(0·48–0·76)

(0·17–0·51)

(0·18–0·71)

(0·18–0·96)

(0·37–0·99)

(0·43–0·61)

(0·42–0·59)

(0·00–0·03)

Other minor†

0·26

0·92

0·65

0·63

0·24

0·76

0·73

0·7

0·03

(0·10–0·49)

(0·75–1·10)

(0·43–0·92)

(0·34–1·00)

(0·05–0·60)

(0·46–1·14)

(0·62–0·84)

(0·60–0·81)

(0·01–0·05)

  1. Other major*: Other major anomalies including total anomalous pulmonary venous drainage, double-outlet left ventricle, aortic atresia, APW, ectopia cordis
  2. Other minor†: Other minor anomalies including tricuspid atresia, mitral valve stenosis, coronary artery fistula, conjoined twins with a heart, mitral atresia, cor triatriatum, ventricular aneurysm, endocardial fibroelastosis, premature closure of the ductus arteriosus, bicuspid aortic valve, cardiac diverticulum
  3. APW = aortopulmonary window. AS = aortic stenosis. AVSD = atrioventricular septal defect. CI = confidence interval. COA/IAA = coarctation of the aorta/interrupted aortic arch. CVR = congenital vascular ring. DORV = double-outlet right ventricle. EA = Ebstein's anomaly. HLHS = hypoplastic left heart syndrome. HRHS = hypoplastic right heart syndrome. HS = heterotaxy syndrome. PA = pulmonary atresia. PLSVC = persistent left superior vena cava. PS = pulmonary stenosis. PTA = persistent truncus arteriosus. RAA = right aortic arch. SV = single ventricle. TGA = transposition of the great arteries. TOF = tetralogy of Fallot. TVS = tricuspid valve stenosis. VSD = ventricular septal defect
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Cell & Bioscience

ISSN: 2045-3701

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