Fig. 6

Inhibition of GCSC proliferation by a combination of chemotherapeutic drugs and ACBP-3. MKN45-derived GCSCs (a); MKN74-derived GCSCs (b). Asterisks representing DDP/ACBP-3 and ACBP-3 vs DDP, P < 0.01; hash symbol representing ACBP-3 vs 5-FU, P < 0.01; open circle and filled triangle representing ACBP-3 vs DDP/ACBP-3 and 5-FU/ACBP-3, P < 0.01, respectively. Relative miR-338-5p expression in GCSCs treated with ACBP-3 and chemotherapeutic drugs. GCSCs derived from MKN45 (c) and MKN74 (d) were treated with ACBP-3 alone or in combination with 5-FU or DDP for 48 h and analyzed for miR-338-5p expression. *P < 0.05, **P < 0.01, 5-FU/ACBP-3 vs 5-FU; filled traingle representing DDP/ACBP-3 vs DDP, P < 0.01; filled circle representing ACBP-3 vs other treatments, P < 0.01