%PDF-1.6
%
1 0 obj
<>
endobj
2 0 obj
<>stream
2017-08-12T07:45:31+05:30
Springer
2017-08-15T06:57:41+02:00
2017-08-15T06:57:41+02:00
Acrobat Distiller 10.1.8 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version)
Diabetic retinopathy,Gene,Epigenetic modifications,DNA methylation,Non-coding RNA,Chromatin remodeling,Histone modification,Therapeutic target
application/pdf
doi:10.1186/s13578-017-0167-1
BioMed Central
Cell & Bioscience, doi:10.1186/s13578-017-0167-1
Diabetic retinopathy
Gene
Epigenetic modifications
DNA methylation
Non-coding RNA
Chromatin remodeling
Histone modification
Therapeutic target
Diabetic retinopathy: reversibility of epigenetic modifications and new therapeutic targets
Xinyuan Zhang
Lin Zhao
Brett Hambly
Shisan Bao
Kaiyue Wang
10.1186/s13578-017-0167-1
2010-04-23
true
springer.com
springerlink.com
"http://dx.doi.org/10.1186/s13578-017-0167-1
10.1186/s13578-017-0167-1
2045-3701
journal
Cell & Bioscience
The Author(s)
2010-04-23
true
10.1186/s13578-017-0167-1
noindex
springer.com
springerlink.com
VoR
uuid:3be7efdc-ce83-4bea-ad43-66c9d2174960
uuid:e9dac259-9df0-47c0-9dc1-64fdb1de461e
default
1
converted
uuid:d935dacd-3ce7-46e9-bc34-4386d983ba8e
converted to PDF/A-2b
pdfToolbox
2017-08-12T07:44:29+05:30
converted
uuid:e7f8359d-7a16-4879-ac5f-99b4496155e4
converted to PDF/A-2b
pdfToolbox
2017-08-12T07:45:02+05:30
2
B
http://ns.adobe.com/pdfx/1.3/
pdfx
Adobe Document Info PDF eXtension Schema
external
Mirrors crossmark:MajorVersionDate
CrossmarkMajorVersionDate
Text
external
Mirrors crossmark:CrossmarkDomainExclusive
CrossmarkDomainExclusive
Text
internal
Mirrors crossmark:DOI
doi
Text
external
Mirrors crossmark:CrosMarkDomains
CrossMarkDomains
seq Text
internal
A name object indicating whether the document has been modified to include trapping information
robots
Text
internal
ID of PDF/X standard
GTS_PDFXVersion
Text
internal
Conformance level of PDF/X standard
GTS_PDFXConformance
Text
internal
Company creating the PDF
Company
Text
internal
Date when document was last modified
SourceModified
Text
http://crossref.org/crossmark/1.0/
crossmark
Crossmark Schema
internal
Usual same as prism:doi
DOI
Text
external
The date when a publication was publishe.
MajorVersionDate
Text
internal
CrossmarkDomainExclusive
CrossmarkDomainExclusive
Text
internal
CrossMarkDomains
CrossMarkDomains
seq Text
http://prismstandard.org/namespaces/basic/2.0/
prism
Prism Schema
external
This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary.
url
URI
external
The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL).
doi
Text
external
ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version.
issn
Text
internal
Volume number
volume
Text
internal
Issue number
number
Text
internal
Starting page
startingPage
Text
internal
Ending page
endingPage
Text
external
The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary.
aggregationType
Text
external
Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.”
publicationName
Text
external
Copyright
copyright
Text
http://ns.adobe.com/pdf/1.3/
pdf
Adobe PDF Schema
internal
A name object indicating whether the document has been modified to include trapping information
Trapped
Text
http://ns.adobe.com/xap/1.0/mm/
xmpMM
XMP Media Management Schema
internal
UUID based identifier for specific incarnation of a document
InstanceID
URI
internal
The common identifier for all versions and renditions of a document.
DocumentID
URI
internal
The common identifier for all versions and renditions of a document.
OriginalDocumentID
URI
http://www.aiim.org/pdfa/ns/id/
pdfaid
PDF/A ID Schema
internal
Part of PDF/A standard
part
Integer
internal
Amendment of PDF/A standard
amd
Text
internal
Conformance level of PDF/A standard
conformance
Text
http://www.niso.org/schemas/jav/1.0/
jav
NISO
external
Values for Journal Article Version are one of the following:
AO = Author’s Original
SMUR = Submitted Manuscript Under Review
AM = Accepted Manuscript
P = Proof
VoR = Version of Record
CVoR = Corrected Version of Record
EVoR = Enhanced Version of Record
journal_article_version
Closed Choice of Text
endstream
endobj
3 0 obj
<>
endobj
8 0 obj
[9 0 R 10 0 R 11 0 R 12 0 R 13 0 R 14 0 R 15 0 R 16 0 R 17 0 R]
endobj
9 0 obj
<>/Rect[239.488 668.391 244.408 656.224]/H/N/AP<>>>
endobj
10 0 obj
<>/Rect[59.8876 392.391 64.8072 380.224]/H/N/AP<>>>
endobj
11 0 obj
<>/Rect[158.928 344.391 163.848 332.224]/H/N/AP<>>>
endobj
12 0 obj
<>/Rect[154.436 296.391 159.356 284.224]/H/N/AP<>>>
endobj
13 0 obj
<>/Rect[86.4817 152.391 91.4503 140.224]/H/N/AP<>>>
endobj
14 0 obj
<>/Rect[96.5243 152.391 101.493 140.224]/H/N/AP<>>>
endobj
15 0 obj
<>/Rect[307.919 380.391 312.839 368.224]/H/N/AP<>>>
endobj
16 0 obj
<>/Rect[432.435 260.391 437.355 248.224]/H/N/AP<>>>
endobj
17 0 obj
<>/Rect[330.624 104.391 335.543 92.2239]/H/N/AP<>>>
endobj
6 0 obj
<>/XObject<>/ProcSet[/PDF/Text]/Font<>>>
endobj
5 0 obj
<>stream
x\V_3 5(1\E1;]T%T5睳ݕ8H,^sYDS7_ݧTYҵ*,<_VEL$]U]ԙ|~ehQ?2^*N\ݯoy^uOjv7(卲NKX\ָ2ŕQYZi?ΪhӶꛦ?<6J}$>Tu)O7")|6QNq|1j,Mբ.d,(Rq-?6yZDyבbVZvtmV<,zmgnYͼ>b]hF-_f*Zg<^$7[.,4bHp4Gire2G8[}Uetͳ<^g.[8 }g2u Z@̹g ,ED'#;(C/rS2G5O,+{`{\5}w@Dz&
ӦEρOn:}E,Љkt<ޯ9*=Z?O YLvrKJd{Oybƶ7pҪO(l3VreHQh?F?D]gQo`_gmYy5Qɲmi֛|u/(ѓ(Iд2[V[2W&?N$yu6e7ܿ 5d?)mj˼ooUMi]3t~`Pz$OՀ6_wW9W,Ί@(fTؐ]GJkVH_*&Zs%<,xb=W sdaHZ;KdCw_XtlZlb^`|NC>yxU?1Yɮ.7'NTj9J4$B1+oWؘQd
!q|Z 8Mecr
]-/+kʪcX8Zo./怿
y99: dP|6|fsiUE 2V 2shmݸV1hXDZ;?䪓q2 hfxNYӈWN9NJ;0}:mL踀+ž#_ 1;g]C?ˤ=ʊ"˙;!uq5[f#
R];8ii3Yj=qdƼs 6v=+|
hdC멁az+8KhN<~FEK|Qe(R1D/ahZ༞5
'<g:7"ڰM LCq(
G\J"sbMu 9vo#-^tǮ}D/$4S(l&Stis}?r>ry'x]+
0&HN\X>Ɉu|[Ejlk؇`Aϻ yuLJ[{FЯOk?|UF=EE@7΄ -!69SzJ<pGy TnAj7]J"_6/p`x9t#^xh]Tݧ%WYѝvZhVOrcH8M4YzrM]Ceg-I<) hΦ'S5yPnMwUr[fgX^T۵\ꀈ
ӌ
P)| cNx QkSmp<]BzS|B3w'0M`\`&mx:|fm_"o+Qq'&ŚWJrecFc Kާ:XYNc
x&Lr7gv8&5L n *T{!dAirj},Y,5գ5iRr`R[_Ϲd p7A[ul1 .?F
z~ Q'P1>ύr q9;&Uҏ,W?+c\SVє xSM~:R)fQh:7L= u=ב+)?N9@٘TY^@v"5WK mdF~QC\]%ĕ=@y*KSQ>u@Uud0ЧԁB5Ų)\x/|<k9k=0ءdoY6k;6oYjl
B>8ItOɽi'*x2L$A]n[2վ5|ztPr_X.?0\2
,5Zk~=IZ>R]R) q[픫%v6"F cER N;'?8̆5M֮a㦡֊bft8yDR KC2]5qTZ~{P%N:d+ lU7-wԂa-eYJT@ v8oWjϠMYQ'+A0g#eJYq<t)[Td/_$Bł~d:d\-ы:IqN䒫W!#4NjJw#"iѱ[O:{{l8;oZ-NӦI"Z55s`WMe" :v۵R{.
}yޡ˙l
y.ct֠|-!!4b"C D.nHZγg{lv=ְS
YQAryNXd=1P$z3]gV?p;Pu@t/M S#j!0=0]2$ʩNiG{.>4&պRE
emgⶃ#n4M
Jz6?2כnd4#^7@j
FA5>Oʊ.2Ul0Yh 8@b7~i1Άlx6<É4ְ!)UUZ^Y>=drE芐fV֍3,*2V[*]ױZ>X̩fH/)Zwc@ԗG;r8߱n%~?A6,H-.u
L&2FTO̝F\CXjJVIL+z
W[p}
c9~Jې&?6,Ȁhr%Hh
iu>}/5ґsyLƷfTDxEl5'cC$ޙrǤHTNCe_wx[x ze9
N A}$(T!WM"bΞ }ΞNW a'02CXt'fNr_ZO4&/ŌNS[3D36#c@niΖa
篰Hj
`c-e@G˸'a#@η;9{\ s[+Q5.?h{$SCsZt}eM
̹g ڝL3XVF
amW-ãFXE&Cm8髗MCc ϲ#~cgqy.B+Ňu(@}6'oŃ@ݚ}F}}k{)4L\Tjz=%,1Mz2疍Hc2}#M_y3
c'Mf6y &NǻԡO:I_8MMu 彸CG XYCDq}b/AxQncf[*y}ܔkatrqQxcIX\!@`kkj(@I
:ŅNeAHȍ'*
CvN"Z$@οr2p!~Pt\fF^J`FuuG<Z6f+/vXnyQ9 Wx!v.W0?ͫvOfGe;$#x̌ppUEtsG:hALSHÉ[;X*Kf>0~ѧP>ʪ@ñij{::5L#R VCU|pzs W4`x$]v3VM#UJ."I*% :$
,H: \cjA0WÁ`tp?jQY<7$3&v8=\@{c~٤zlhrt'Jef0sQֱ 9K+t=;-hm
[(Iedd+)ɽ+kV@(Mr2)"j;#^CJtpt@[CILA,@het>׃
TU9*@HҥgZw?QñO&-IxLilW0xYy30(S:Zt#~{dփ7~$5dSDS4cjX!HՇȔPf:d>ي ss>[F}&)[
֟WXU֜N9*ꮨBH.ϜWouYD/X/2}vCzyFj|ڃ{ggߗSowP|f$>
endobj
40 0 obj
[41 0 R 42 0 R 43 0 R 44 0 R 45 0 R 46 0 R 47 0 R 48 0 R 49 0 R 50 0 R 51 0 R 52 0 R 53 0 R 54 0 R 55 0 R 56 0 R 57 0 R 58 0 R 59 0 R]
endobj
41 0 obj
<>/Rect[133.649 524.693 138.568 512.527]/H/N/AP<>>>
endobj
42 0 obj
<>/Rect[161.073 380.693 170.912 362.034]/H/N/AP<>>>
endobj
43 0 obj
<>/Rect[405.5 620.391 415.339 608.224]/H/N/AP<>>>
endobj
44 0 obj
<>/Rect[451.002 584.391 460.841 572.224]/H/N/AP<>>>
endobj
45 0 obj
<>/Rect[372.345 548.391 382.184 536.224]/H/N/AP<>>>
endobj
46 0 obj
<>/Rect[483.109 416.391 492.949 404.224]/H/N/AP<>>>
endobj
47 0 obj
<>/Rect[526.327 416.391 531.246 404.224]/H/N/AP<>>>
endobj
48 0 obj
<>/Rect[446.967 344.391 456.807 332.224]/H/N/AP<>>>
endobj
49 0 obj
<>/Rect[461.395 344.391 471.234 332.224]/H/N/AP<>>>
endobj
50 0 obj
<>/Rect[345.497 248.391 355.336 236.224]/H/N/AP<>>>
endobj
51 0 obj
<>/Rect[471.399 248.391 481.238 236.224]/H/N/AP<>>>
endobj
52 0 obj
<>/Rect[327.873 236.391 337.712 224.224]/H/N/AP<>>>
endobj
53 0 obj
<>/Rect[469.342 236.391 479.181 224.224]/H/N/AP<>>>
endobj
54 0 obj
<>/Rect[111.068 155.464 114.972 146.4]/H/N/AP<>>>
endobj
55 0 obj
<>/Rect[91.6604 143.364 99.4683 134.3]/H/N/AP<>>>
endobj
56 0 obj
<>/Rect[140.764 122.264 148.571 113.2]/H/N/AP<>>>
endobj
57 0 obj
<>/Rect[92.8604 101.164 100.668 92.1]/H/N/AP<>>>
endobj
58 0 obj
<>/Rect[88.6282 92.164 96.4361 83.1]/H/N/AP<>>>
endobj
59 0 obj
<>/Rect[140.764 80.014 148.571 70.95]/H/N/AP<>>>
endobj
38 0 obj
<>/XObject<>/ProcSet[/PDF/Text]/Font<>>>
endobj
37 0 obj
<>stream
x\koIvQ?!lwUlivE&dAiM6$knE҃Y]u>=V׳@ۓo>v{r&'R̾d]&@2#a.XL"Eq*f˓K|]P_D6m''8i fO^Y}_H&~VTYf
qIbu+&U~.<ϳ,~gsnE5/=_NRoQUuYooJ!<j" qBO${K$0#XN>n"*&+]!|(1{2BgIvg>dTxe}?F~mvu/55ZYʇ(3gDfv_y3^ɓ +bYL@O\^
.`ƌS̳~#h$X6 "_Ak2b"o.,]yQpg`bCq]kJ-UlIe^QkLZ ̵2Z)iok SO#iP{Qs_AQ>ƃ>$'Rn$Q.b9qca]-|Ls^
~ta~XUm-£Njwhwe|wfaRv7]
F5~c"̹%p_igA[&5#RA㕅_-Ng7
Iܕ
zbZC917ak8K`mg M1Gq FnU.ռdupEZVՎ!j8]"y?k5A*#YX
~ȃ
zHD_d֕F|z7e*j.*ڶ![o3<}a/^c0/bU/|ȋAh;riJ,:e84<$~-C2"WuNnѰ
=j&[Џ
^fVxp)qN=
B;R??x9W'5/|BN4I<nў
Yʼz!n 5v_笄bUTn`y7ɡ3C+ZevGPfTwe8 /D?ypLW@܁,.TU#<GT7fo$y`CYV(
0@7#$۲IX0T*3ј7(V0,(1P nN:n8O =F])3aW0W}:ၩLqʾ,Ѵ3w5=UU
G]wf*3Ty~9Sɨ6bUOmCkOO Q]Bۋf\ka`ufVqSO\bBtd=h~pą&
! B!7LfR2mB:NF<|!u`!>@D~k!@&r[( 8)_q9g;S(BőjWDf+)_I.C9PQu%cXhQ&(#l:lC@ 4G@>SWgMiiV6)
+#o4[
jjHHiCW(ZJݽoX| vRNӋt.*GU^"a*6͝CVb # dמwM% hC*LAK2e02ͬ0edjbQL$ysT^pi'`ō;֪6r[HKnٛJ):ݚ{T7ڍܔ&+lUӖr4 :jә&r.XT+[nM> WфUf1I1U=s薬L]bea0ݨ!$I`GɢN3(4h3rf멢uJ ͈ڮݟߌ>z5ݱilP7:t]Z1]놮=@z#&S{Vnn(KMFpy \zǴIwbEm0$Vi~2`n;b5神H[Q}[)tk2RcJ(nw榒oh Q)&~
nSWeKkfj]J5n)>ؼ[@lktkb,W0H%qWrGOgC<O /[C-*&2m]MGX0*MX9 wEs[5RDr~B@'6I7XKveo*s|zFbc o&^],##:s Qi;0`QiGʭ/+[l`ikf{A}r` ;me L/K96Ԁzs@Zlj