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  1. Cardiac fibrosis is characterized by excessive extracellular matrix deposition that contributes to compromised cardiac function and potentially heart failure. Disruptor of telomeric silencing 1-like (Dot1L) is...

    Authors: Jie Xu, Jinghuan Wang, Fen Long, Wen Zhong, Haibi Su, Zhenghua Su and Xinhua Liu
    Citation: Cell & Bioscience 2022 12:134
  2. Age-related macular degeneration (AMD) leads to gradual central vision loss and eventual irreversible blindness. Melatonin, an endogenous hormone, exhibits anti-inflammatory and antitumor effects; however, the...

    Authors: Kai Wang, Yong-Syuan Chen, Hsiang-Wen Chien, Hui-Ling Chiou, Shun-Fa Yang and Yi-Hsien Hsieh
    Citation: Cell & Bioscience 2022 12:133
  3. Urological cancers are common malignant cancers worldwide, with annually increasing morbidity and mortality rates. For decades, two-dimensional cell cultures and animal models have been widely used to study th...

    Authors: Haotian Chen, Wentao Zhang, Niraj Maskey, Fuhan Yang, Zongtai Zheng, Cheng Li, Ruiliang Wang, Pengfei Wu, Shiyu Mao, Junfeng Zhang, Yang Yan, Wei Li and Xudong Yao
    Citation: Cell & Bioscience 2022 12:132
  4. The mammalian target of rapamycin (mTOR) plays a critical role in controlling cellular homeostasis, and its dysregulation has been implicated in Alzheimer’s disease (AD). Presenilin-1 (PS1) mutations account f...

    Authors: Cheong-Meng Chong, Yuan Tan, Jiaqi Tong, Minjing Ke, Ke Zhang, Lingli Yan, Xiaotong Cen, Jia-Hong Lu, Guobing Chen, Huanxing Su and Dajiang Qin
    Citation: Cell & Bioscience 2022 12:131
  5. The endoplasmic reticulum (ER) is a multi-layered organelle that is essential for the synthesis, folding, and structural maturation of almost one-third of the cellular proteome. It houses several resident prot...

    Authors: Nisa Syakila A. Rahman, Syazalina Zahari, Saiful Effendi Syafruddin, Mohd Firdaus-Raih, Teck Yew Low and M. Aiman Mohtar
    Citation: Cell & Bioscience 2022 12:129
  6. Reactive astrocytes are increasingly recognized as crucial regulators of innate immunity in degenerative or damaged central nervous system (CNS). Many proinflammatory mediators have been shown to drive inflamm...

    Authors: Hui Li, Bingqiang He, Xingyuan Zhang, Huifei Hao, Ting Yang, Chunshuai Sun, Honghua Song, Yingjie Wang, Yue Zhou, Zhenjie Zhu, Yuming Hu and Yongjun Wang
    Citation: Cell & Bioscience 2022 12:128
  7. Different pathologies, affecting the skeletal system, were reported to display altered bone and/or cartilage innervation profiles leading to the deregulation of the tissue homeostasis. The patterning of periph...

    Authors: Estrela Neto, Luís Leitão, José C. Mateus, Daniela M. Sousa, Cecília J. Alves, Miguel Aroso, Ana C. Monteiro, Francisco Conceição, Richard O. C. Oreffo, Jonathan West, Paulo Aguiar and Meriem Lamghari
    Citation: Cell & Bioscience 2022 12:127
  8. Alternative splicing (AS) of genes has been found to affect gene stability, and its abnormal regulation can lead to tumorigenesis. CELF2 is a vital splicing factor to participate in mRNA alternative splicing. ...

    Authors: Shihui Lai, Yan Wang, Ting Li, Yihong Dong, Yihao Lin, Liang Wang, Shangeng Weng, Xiang Zhang and Chengjie Lin
    Citation: Cell & Bioscience 2022 12:125
  9. Targeting the HGF/MET signaling pathway has been a viable therapeutic strategy for various cancer types due to hyperactivation of HGF/MET axis occurs frequently that leads to detrimental cancer progression and...

    Authors: Pei-Yi Chu, Wei-Chieh Huang, Shiao-Lin Tung, Chung-Ying Tsai, Chih Jung Chen, Yu-Chin Liu, Chia-Wen Lee, Yang-Hsiang Lin, Hung-Yu Lin, Cheng-Yi Chen, Chau-Ting Yeh, Kwang-Huei Lin and Hsiang-Cheng Chi
    Citation: Cell & Bioscience 2022 12:124
  10. Fibroblasts have important roles in the synthesis and remodeling of extracellular matrix (ECM) proteins during pulmonary fibrosis. However, the spatiotemporal distribution of heterogeneous fibroblasts during d...

    Authors: Xiaoni Shi, Jing Wang, Xinxin Zhang, Shaoqi Yang, Wei Luo, Sha Wang, Jie Huang, Mengling Chen, Yusi Cheng and Jie Chao
    Citation: Cell & Bioscience 2022 12:123
  11. Constitutive activation of PI3K signaling has been well recognized in a subset of small cell lung cancer (SCLC), the cancer type which has the most aggressive clinical course amongst pulmonary tumors. Whereas ...

    Authors: Ming-Chun Hung, Wan-Ping Wang and Ya-Hui Chi
    Citation: Cell & Bioscience 2022 12:122
  12. Tick-borne encephalitis (TBE) is a disease affecting the central nervous system. Over the last decade, the incidence of TBE has steadily increased in Europe and Asia despite the availably of effective vaccines...

    Authors: Gabriele Chiffi, Denis Grandgirard, Sabrina Stöckli, Luca G. Valente, Antoine Adamantidis and Stephen L. Leib
    Citation: Cell & Bioscience 2022 12:121
  13. Colorectal liver metastases (CRLM) continue to have a low survival rate. The number of CRLM regulators and clinical indicators remains limited. Long non-coding RNAs (lncRNAs) are a new master regulator of cell...

    Authors: Zhe Wang, Jianfang Chen, Fengjun Sun, Xiang Zhao, Yan Dong, Songtao Yu, Jianjun Li and Houjie Liang
    Citation: Cell & Bioscience 2022 12:120
  14. Developmental signaling pathways such as those of Hedgehog (HH) and WNT play critical roles in cancer stem cell self-renewal, migration, and differentiation. They are often constitutively activated in many hum...

    Authors: Liu-Ya Tang, Marie Spezia, Ting Chen, Jee-Hye Shin, Feng Wang, Frank Stappenbeck, Andres M. Lebensohn, Farhad Parhami and Ying E. Zhang
    Citation: Cell & Bioscience 2022 12:119
  15. The activation of the hypothalamic–pituitary–adrenal (HPA) axis is essential for metabolic adaptation in response to fasting. However, the neurocircuitry connecting changes in the peripheral energy stores to t...

    Authors: Alan Carlos Alves Fernandes, Franciane Pereira de Oliveira, Gimena Fernandez, Luane da Guia Vieira, Cristiane Gugelmin Rosa, Taís do Nascimento, Suzelei de Castro França, Jose Donato Jr., Kristen R. Vella, Jose Antunes-Rodrigues, André Souza Mecawi, Mario Perello, Lucila Leico Kagohara Elias and Rodrigo Rorato
    Citation: Cell & Bioscience 2022 12:118

    The Correction to this article has been published in Cell & Bioscience 2022 12:146

  16. Fibrosis is a pathological feature of a variety of chronic inflammatory diseases that can affect almost all organs, which can cause severe consequences and even lead to death. Fibrosis is characterized by the ...

    Authors: Xiangyu Zhao, Jiayin Chen, Hongxiang Sun, Yao Zhang and Duowu Zou
    Citation: Cell & Bioscience 2022 12:117

    The Correction to this article has been published in Cell & Bioscience 2022 12:138

  17. The degeneration of retinal pigmented epithelium (RPE) cells results in severe diseases, such as age-related macular degeneration (AMD) that causes blindness in millions of individuals.

    Authors: Jing Li, Feng Zhang, Wei Bian, Yanyun Chen, Jianying Liu, Zhenyu Liu, Ying Xiong and Xiuhua Wan
    Citation: Cell & Bioscience 2022 12:116
  18. Mesenchymal stromal cells (MSCs) are heterogeneous populations. Heterogeneity exists within the same tissue and between different tissues. Some studies have found enormous heterogeneity in immunomodulatory fun...

    Authors: Siyu Cai, Chuiqin Fan, Lichun Xie, Huifeng Zhong, Aijia Li, Siyu Lv, Maochuan Liao, Xixi Yang, Xing Su, Yue Wang, Hongwu Wang, Manna Wang, Peng Huang, Yulin Liu, Yu Wang, Yufeng Liu…
    Citation: Cell & Bioscience 2022 12:115
  19. Neutrophil extracellular traps (NETs) contribute to the creation of a coagulation state in various diseases. Currently, it is not clear whether NETs are present in the thrombi and plasma of patients with cereb...

    Authors: Jiaqi Jin, Shan Qiao, Jie Liu, Wenqiang Li, Fang Wang, Xin Gao, Jiawei Tian, Nan Wang, Jiheng Zhang, Jiawei Dong, Haiyun li, Jianjun Wang, Shaoshan Hu and Peng Zhou
    Citation: Cell & Bioscience 2022 12:114
  20. Previous data have reported that Sentrin/SUMO-specific protease 6 (SENP6) is involved in ischaemic brain injury and induces neuronal apoptosis after cerebral ischaemia, but the role of SENP6 in microglia-induc...

    Authors: Meng Mao, Qian Xia, Gao-Feng Zhan, Qin-Jun Chu, Xing Li and Hong-Kai Lian
    Citation: Cell & Bioscience 2022 12:113
  21. As the understanding of skeletal muscle inflammation is increasingly clarified, the role of Treg cells in the treatment of skeletal muscle diseases has attracted more attention in recent years. A consensus has...

    Authors: Ziyu Chen, HaiQiang Lan, ZhaoHong Liao, JingWen Huang, XiaoTing Jian, Jijie Hu and Hua Liao
    Citation: Cell & Bioscience 2022 12:112
  22. More than 70% of leiomyomas (LM) harbor MED12 mutations, primarily in exon 2 at c.130-131(GG). The cause of MED12 mutations in myometrial cells remains largely unknown. We hypothesized that increased ROS promotes...

    Authors: Yinuo Li, Xiuhua Xu, Huma Asif, Yue Feng, Brendan F. Kohrn, Scott R. Kennedy, J. Julie Kim and Jian-Jun Wei
    Citation: Cell & Bioscience 2022 12:111
  23. Spastin significantly influences microtubule regulation in neurons and is implicated in the pathogenesis of hereditary spastic paraplegia (HSP). However, post-translational regulation of the spastin protein re...

    Authors: Hyun Mi Kang, Dae Hun Kim, Mijin Kim, Yoohong Min, Bohyeon Jeong, Kyung Hee Noh, Da Yong Lee, Hyun-Soo Cho, Nam-Soon Kim, Cho-Rok Jung and Jung Hwa Lim
    Citation: Cell & Bioscience 2022 12:110
  24. Pulmonary metastasis is the main cause of poor prognosis in osteosarcoma. Sialic acid-bound immunoglobulin lectin 15 (Siglec-15) has been demonstrated to be obviously correlated with pulmonary metastasis in os...

    Authors: Bingxin Zheng, Keliang Song, Lingling Sun, Yang Gao, Yan Qu, Chongmin Ren, Peng Yan, Wenfang Chen, Wei Guo, Chuanli Zhou and Bin Yue
    Citation: Cell & Bioscience 2022 12:109
  25. Diabetic retinopathy (DR) is a microvascular complication of diabetes with a heavy impact on the quality of life of subjects and with a dramatic burden for health and economic systems on a global scale. Althou...

    Authors: Diego Sbardella, Grazia Raffaella Tundo, Alice Mecchia, Camilla Palumbo, Maria Grazia Atzori, Lauretta Levati, Alessandra Boccaccini, Anna Maria Caccuri, Paolo Cascio, Pedro Miguel Lacal, Grazia Graziani, Monica Varano, Massimiliano Coletta and Mariacristina Parravano
    Citation: Cell & Bioscience 2022 12:108
  26. Histone deacetylation is one of the most important epigenetic modifications and plays diverse roles in plant development. However, the detailed functions and mechanisms of histone deacetylation in fiber develo...

    Authors: Zhenzhen Wei, Yonghui Li, Faiza Ali, Ye Wang, Jisheng Liu, Zuoren Yang, Zhi Wang, Yadi Xing and Fuguang Li
    Citation: Cell & Bioscience 2022 12:107
  27. The importance of neuroglia in maintaining normal brain function under physiological and pathological conditions has been supported by growing evidence in recent years. The most important issues regarding glia...

    Authors: Danying Yang, Xifeng Wang, Lieliang Zhang, Yang Fang, Qingcui Zheng, Xing Liu, Wen Yu, Shoulin Chen, Jun Ying and Fuzhou Hua
    Citation: Cell & Bioscience 2022 12:106
  28. Human mesenchymal stromal cells (MSCs) have been widely advocated to clinical use. Human skin dermis-derived fibroblasts shared similar cellular morphology and biological characteristics to MSCs, while it stil...

    Authors: Chenxu Tai, Zhengyao Xie, Yu Li, Yirui Feng, Yuanyuan Xie, Hui Yang, Liudi Wang and Bin Wang
    Citation: Cell & Bioscience 2022 12:105
  29. The true diploid frog, Xenopus tropicalis (X. tropicalis) is an excellent genetic model organism. To date, the CRISPR/Cas-mediated genome editing methods established in this species are mostly based on SpCas9 tha...

    Authors: Zhaoying Shi, Hao Jiang, Guanghui Liu, Songyuan Shi, Xuan Zhang and Yonglong Chen
    Citation: Cell & Bioscience 2022 12:104
  30. Neurodegenerative diseases encompass an extensive and heterogeneous group of nervous system disorders which are characterized by progressive degeneration and death of neurons. Many lines of evidence suggest th...

    Authors: Xihui Chen, Fangfang Liu, Bowen Li, Yufeng Wang, Lijuan Yuan, Anan Yin, Qi Chen, Weihong Hu, Yan Yao, Mengjie Zhang, YuanMing Wu and Kun Chen
    Citation: Cell & Bioscience 2022 12:103
  31. Parkinson’s Disease (PD) is the second most frequent degenerative disorder, the risk of which increases with age. A preclinical PD diagnostic test does not exist. We identify PD blood metabolites and metabolic...

    Authors: Nicola D’Ascenzo, Emanuele Antonecchia, Antonella Angiolillo, Victor Bender, Marco Camerlenghi, Qingguo Xie and Alfonso Di Costanzo
    Citation: Cell & Bioscience 2022 12:102
  32. The National Institutes of Health’s Asian American, Native Hawaiian and Pacific Islander Health Scientific Interest Group (NIH AANHPI-HSIG) provides a viewpoint on developing approaches to enhance research on ...

    Authors: Dan Xi, Ming Lei, Paul Liu, Ramesh Vemuri and Yihong Ye
    Citation: Cell & Bioscience 2022 12:101
  33. Non-alcoholic fatty liver disease (NAFLD) is a metabolic disease characterized by multiple pathologies. The progression of dementia with NAFLD may be affected by various risk factors, including brain insulin r...

    Authors: So Yeong Cheon and Juhyun Song
    Citation: Cell & Bioscience 2022 12:99
  34. Aberrant DNA methylation patterns, including hypermethylation of key genes that inhibit fibrosis and inflammation, have been described in human kidney diseases. However, the role of DNA methyltransferase 1 (DN...

    Authors: Haochen Guan, Nan Zhu, Gang Tang, Yi Du, Ling Wang and Weijie Yuan
    Citation: Cell & Bioscience 2022 12:98
  35. Pancreatic cancer (PC) is a highly malignant solid tumor with insidious onset and easy early metastasis. Despite tremendous efforts devoted to research in this field, the mechanisms underlying PC tumorigenesis...

    Authors: Qun Chen, Jiajia Li, Peng Shen, Hao Yuan, Jie Yin, Wanli Ge, Wujun Wang, Guangbin Chen, Taoyue Yang, Bin Xiao, Yi Miao, Zipeng Lu, Pengfei Wu and Kuirong Jiang
    Citation: Cell & Bioscience 2022 12:97
  36. The microarray data analysis predicted that Rbpjl is poorly expressed in acute pancreatitis (AP). Activated IL-6/STAT3 signaling is further known to contribute to the progression of AP through immune regulatio...

    Authors: Jiachen Lv, Min Fang, Shijie Sun, Gang Wang, Songbin Fu, Bei Sun and Jinxue Tong
    Citation: Cell & Bioscience 2022 12:95
  37. Muscle atrophy is an increasingly global health problem affecting millions, there is a lack of clinical drugs or effective therapy. Excessive loss of muscle mass is the typical characteristic of muscle atrophy...

    Authors: Jin Chen, Zihua Li, Yudian Zhang, Xu Zhang, Shujie Zhang, Zonghan Liu, Huimei Yuan, Xiangsheng Pang, Yaxuan Liu, Wuchen Tao, Xiaoping Chen, Peng Zhang and Guo-Qiang Chen
    Citation: Cell & Bioscience 2022 12:94
  38. RNA is spliced concomitantly with transcription and the process is organized by RNA splicing factors, transcriptional regulators, and chromatin regulators. RNA is spliced in close proximity to transcription ma...

    Authors: Koji Kitamura, Hidefumi Suzuki, Ryota Abe, Hidenori Inohara, Yasufumi Kaneda, Hidehisa Takahashi and Keisuke Nimura
    Citation: Cell & Bioscience 2022 12:92
  39. Cerebral malaria (CM) is a preeminent cause of severe disease and premature deaths in Sub-Saharan Africa, where an estimated 90% of cases occur. The key features of CM are a deep, unarousable coma that persist...

    Authors: Lydia Nkuah Nortey, Alberta Serwah Anning, Gideon Kwesi Nakotey, Abdala Mumuni Ussif, Yeboah Kwaku Opoku, Silas Acheampong Osei, Benjamin Aboagye and George Ghartey-Kwansah
    Citation: Cell & Bioscience 2022 12:91
  40. Major depressive disorder is characterized by not only monoamine neurotransmitters deficiencies but also persistent neuroinflammation. The complement system is an attractive therapeutic target for various infl...

    Authors: Man-Man Zhang, Min-Xia Guo, Qiu-Ping Zhang, Xue-Qin Chen, Na-Zhi Li, Qing Liu, Jie Cheng, Shi-Le Wang, Guang-Hui Xu, Cheng-Fu Li, Ji-Xiao Zhu and Li-Tao Yi
    Citation: Cell & Bioscience 2022 12:90
  41. The exit from pluripotency or pluripotent-somatic transition (PST) landmarks an event of early mammalian embryonic development, representing a model for cell fate transition.

    Authors: Runxia Lin, Ziwei Zhai, Junqi Kuang, Chuman Wu, Yuxiang Yao, Ruona Shi, Jiangping He, Shuyang Xu, Pengli Li, Yixin Fan, Wei Li, Zichao Wu, Xiaoxi Li, Jin Ming, Jing Guo, Bo Wang…
    Citation: Cell & Bioscience 2022 12:89
  42. An animal model that can mimic the SARS-CoV-2 infection in humans is critical to understanding the rapidly evolving SARS-CoV-2 virus and for development of prophylactic and therapeutic strategies to combat eme...

    Authors: Saiaditya Badeti, Qingkui Jiang, Alireza Naghizadeh, Hsiang-chi Tseng, Yuri Bushkin, Salvatore A. E. Marras, Annuurun Nisa, Sanjay Tyagi, Fei Chen, Peter Romanienko, Ghassan Yehia, Deborah Evans, Moises Lopez-Gonzalez, David Alland, Riccardo Russo, William Gause…
    Citation: Cell & Bioscience 2022 12:88
  43. In the evolutionary “arms race” from prokaryotes to eukaryotes, some memories of foreign DNA have been conserved for defensive purposes. Shortly after invasion by the plasmid, pEGFP-N1, the conserved the defen...

    Authors: Nan Li, Dongya Jiang, Luqingqing He, Yunyun Yue, Qinxin Zhang, Shuang Wang, Yunfeng Zhang, Yuxuan Wei and Qingshun Zhao
    Citation: Cell & Bioscience 2022 12:87
  44. Disease caused by the capsular group B meningococcus (MenB) is the leading cause of infectious death in UK infants. A novel adenovirus-based vaccine encoding the MenB factor H binding protein (fHbp) with an N-...

    Authors: Dylan Sheerin, Christina Dold, Laura Silva-Reyes, Aline Linder, Andrew J. Pollard and Christine S. Rollier
    Citation: Cell & Bioscience 2022 12:86
  45. mRNA processing is an essential step of gene expression; its malfunction can lead to different degrees of physiological disorder from subclinical disease to death. We previously identified Dido1 as a stemness mar...

    Authors: Julio Gutiérrez, Karel H. M. van Wely and Carlos Martínez-A
    Citation: Cell & Bioscience 2022 12:84

    The Correction to this article has been published in Cell & Bioscience 2022 12:144