Articles
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Citation: Cell & Bioscience 2023 13:22
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RNA binding protein SAMD4: current knowledge and future perspectives
SAMD4 protein family is a class of novel RNA-binding proteins that can mediate post-transcriptional regulation and translation repression in eukaryotes, which are highly conserved from yeast to humans during e...
Citation: Cell & Bioscience 2023 13:21 -
Modulation of foraging-like behaviors by cholesterol-FGF19 axis
Foraging for food precedes food consumption and is an important component of the overall metabolic programming that regulates feeding. Foraging is governed by central nervous system neuronal circuits but how i...
Citation: Cell & Bioscience 2023 13:20 -
Dynamic single-cell RNA-seq analysis reveals distinct tumor program associated with microenvironmental remodeling and drug sensitivity in multiple myeloma
Multiple myeloma (MM) is a hematological malignancy characterized by clonal proliferation of malignant plasma cells. Despite extensive research, molecular mechanisms in MM that drive drug sensitivity and clini...
Citation: Cell & Bioscience 2023 13:19 -
14-3-3 proteins regulate cullin 7-mediated Eag1 degradation
Mutations in the human gene encoding the neuron-specific Eag1 (KV10.1; KCNH1) potassium channel are linked to congenital neurodevelopmental diseases. Disease-causing mutant Eag1 channels manifest aberrant gating ...
Citation: Cell & Bioscience 2023 13:18 -
Predictive biomarkers for the responsiveness of recurrent glioblastomas to activated killer cell immunotherapy
Recurrent glioblastoma multiforme (GBM) is a highly aggressive primary malignant brain tumor that is resistant to existing treatments. Recently, we reported that activated autologous natural killer (NK) cell t...
Citation: Cell & Bioscience 2023 13:17 -
Identification of the molecular mechanism of insulin-like growth factor-1 (IGF-1): a promising therapeutic target for neurodegenerative diseases associated with metabolic syndrome
Neurodegenerative disorders are accompanied by neuronal degeneration and glial dysfunction, resulting in cognitive, psychomotor, and behavioral impairment. Multiple factors including genetic, environmental, me...
Citation: Cell & Bioscience 2023 13:16 -
AMPK attenuates SHH subgroup medulloblastoma growth and metastasis by inhibiting NF-κB activation
Medulloblastoma (MB) is one of the most common malignant pediatric brain tumors. Metastasis and relapse are the leading causes of death in MB patients. The initiation of the SHH subgroup of MB (SHH-MB) is due ...
Citation: Cell & Bioscience 2023 13:15 -
Brain nuclear receptors and cardiovascular function
Brain–heart interaction has raised up increasing attentions. Nuclear receptors (NRs) are abundantly expressed in the brain, and emerging evidence indicates that a number of these brain NRs regulate multiple as...
Citation: Cell & Bioscience 2023 13:14 -
Hypofucosylation of Unc5b regulated by Fut8 enhances macrophage emigration and prevents atherosclerosis
Atherosclerosis (AS) is the leading underlying cause of the majority of clinical cardiovascular events. Retention of foamy macrophages in plaques is the main factor initiating and promoting the atherosclerotic...
Citation: Cell & Bioscience 2023 13:13 -
Loss of TET2 impairs endothelial angiogenesis via downregulating STAT3 target genes
Ischemic diseases represent a major global health care burden. Angiogenesis is critical in recovery of blood flow and repair of injured tissue in ischemic diseases. Ten–eleven translocation protein 2 (TET2), a...
Citation: Cell & Bioscience 2023 13:12 -
Comparison of DNA targeting CRISPR editors in human cells
Profiling and comparing the performance of current widely used DNA targeting CRISPR systems provide the basic information for the gene-editing toolkit and can be a useful resource for this field. In the curren...
Citation: Cell & Bioscience 2023 13:11 -
Small molecule modulators of chromatin remodeling: from neurodevelopment to neurodegeneration
The dynamic changes in chromatin conformation alter the organization and structure of the genome and further regulate gene transcription. Basically, the chromatin structure is controlled by reversible, enzyme-...
Citation: Cell & Bioscience 2023 13:10 -
Flavivirus prM interacts with MDA5 and MAVS to inhibit RLR antiviral signaling
Vector-borne flaviviruses, including tick-borne encephalitis virus (TBEV), Zika virus (ZIKV), West Nile virus (WNV), yellow fever virus (YFV), dengue virus (DENV), and Japanese encephalitis virus (JEV), pose a...
Citation: Cell & Bioscience 2023 13:9 -
Photobiomodulation improves the synapses and cognitive function and ameliorates epileptic seizure by inhibiting downregulation of Nlgn3
Temporal lobe epilepsy (TLE) remains one of the most drug-resistant focal epilepsies. Glutamate excitotoxicity and neuroinflammation which leads to loss of synaptic proteins and neuronal death appear to repres...
Citation: Cell & Bioscience 2023 13:8 -
Activation of goblet cell Piezo1 alleviates mucus barrier damage in mice exposed to WAS by inhibiting H3K9me3 modification
Our recent studies found that intestinal mechanical signals can regulate mucus synthesis and secretion of intestinal goblet cells through piezo type mechanosensitive ion channel component 1 (Piezo1), but the d...
Citation: Cell & Bioscience 2023 13:7 -
Metabolic disorder and intestinal microflora dysbiosis in chronic inflammatory demyelinating polyradiculoneuropathy
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a rare acquired immune-mediated neuropathy. Although microbial infection is potentially a contributing factor, a causative link between CIDP ...
Citation: Cell & Bioscience 2023 13:6 -
Knockout of secretin ameliorates biliary and liver phenotypes during alcohol-induced hepatotoxicity
Alcohol-related liver disease (ALD) is characterized by ductular reaction (DR), liver inflammation, steatosis, fibrosis, and cirrhosis. The secretin (Sct)/secretin receptor (SR) axis (expressed only by cholang...
Citation: Cell & Bioscience 2023 13:5 -
Electric field stimulation boosts neuronal differentiation of neural stem cells for spinal cord injury treatment via PI3K/Akt/GSK-3β/β-catenin activation
Neural stem cells (NSCs) are considered as candidates for cell replacement therapy in many neurological disorders. However, the propensity for their differentiation to proceed more glial rather than neuronal p...
Citation: Cell & Bioscience 2023 13:4 -
Nrf2 is predominantly expressed in hippocampal neurons in a rat model of temporal lobe epilepsy
Drug resistance is a particular problem in patients with temporal lobe epilepsy, where seizures originate mainly from the hippocampus. Many of these epilepsies are acquired conditions following an insult to th...
Citation: Cell & Bioscience 2023 13:3 -
Single-cell DNA methylation sequencing by combinatorial indexing and enzymatic DNA methylation conversion
DNA methylation is a critical molecular mark involved in cellular differentiation and cell-specific processes. Single-cell whole genome DNA methylation profiling methods hold great potential to resolve the DNA...
Citation: Cell & Bioscience 2023 13:2 -
Neural function of Bmal1: an overview
Bmal1 (Brain and muscle arnt-like, or Arntl) is a bHLH/PAS domain transcription factor central to the transcription/translation feedback loop of the biologic clock. Although Bmal1 is well-established as a major r...
Citation: Cell & Bioscience 2023 13:1 -
Targeting G-quadruplex for rescuing impaired chondrogenesis in WRN-deficient stem cells
Pathogenic mutations in WRN are a cause of premature aging disease Werner syndrome (WS). Besides accelerated aging phenotypes and cancer predisposition, patients with WS also display underdevelopment in the skele...
Citation: Cell & Bioscience 2022 12:212 -
SPOP inhibits BRAF-dependent tumorigenesis through promoting non-degradative ubiquitination of BRAF
The gene encoding the E3 ubiquitin ligase substrate-binding adapter Speckle-type BTB/POZ protein (SPOP) is frequently mutated in prostate cancer (PCa) and endometrial cancer (EC); however, the molecular mechanism...
Citation: Cell & Bioscience 2022 12:211 -
Inhibition of PI3 kinase isoform p110α suppresses neuroblastoma growth and induces the reduction of Anaplastic Lymphoma Kinase
In neuroblastoma, hyperactivation of the PI3K signaling pathway has been correlated with aggressive neuroblastomas, suggesting PI3Ks as promising targets for the treatment of neuroblastoma. However, the oncoge...
Citation: Cell & Bioscience 2022 12:210 -
A new thinking: deciphering the aberrance and clinical implication of copper-death signatures in clear cell renal cell carcinoma
Recent research has indicated that cuprotosis, or copper induced cell death, is a novel type of cell death that could be utilized as a new weapon for cancer management. However, the characteristics and implica...
Citation: Cell & Bioscience 2022 12:209 -
A novel promising diagnosis model for colorectal advanced adenoma and carcinoma based on the progressive gut microbiota gene biomarkers
Colorectal cancer (CRC), a commonly diagnosed cancer often develops slowly from benign polyps called adenoma to carcinoma. Altered gut microbiota is implicated in colorectal carcinogenesis. It is warranted to ...
Citation: Cell & Bioscience 2022 12:208 -
RNA N6-methyladenosine modification mediates downregulation of NR4A1 to facilitate malignancy of cervical cancer
N6-methyladenosine is the most abundant eukaryotic mRNA modification and alters a wide range of cellular processes in cancer. Therefore, defining the molecular details are critical for understanding the regulato....
Citation: Cell & Bioscience 2022 12:207 -
Discovery and mechanism studies of a novel ATG4B inhibitor Ebselen by drug repurposing and its anti-colorectal cancer effects in mice
Cysteine protease ATG4B, a key autophagy protein, is an attractive target for colorectal cancer therapy. However, ATG4B inhibitors with higher efficiency, safety, and clear mechanism are still limited. In this...
Citation: Cell & Bioscience 2022 12:206 -
Phosphorylation of adducin-1 by TPX2 promotes interpolar microtubule homeostasis and precise chromosome segregation in mouse oocytes
ADD1 (adducin-1) and TPX2 (targeting protein for Xklp2) are centrosomal proteins and regulate mitotic spindle assembly. Mammalian oocytes that segregate homologous chromosomes in Meiosis I and sister chromatid...
Citation: Cell & Bioscience 2022 12:205 -
FOXO3a-dependent PARKIN negatively regulates cardiac hypertrophy by restoring mitophagy
Sustained cardiac hypertrophy often develops maladaptive myocardial remodeling, and eventually progresses to heart failure and sudden death. Therefore, maladaptive hypertrophy is considered as a critical thera...
Citation: Cell & Bioscience 2022 12:204 -
VHL-recruiting PROTAC attenuates renal fibrosis and preserves renal function via simultaneous degradation of Smad3 and stabilization of HIF-2α
Renal fibrosis is the pathological foundation of various chronic kidney diseases progressing to end stage renal failure. However, there are currently no nephroprotective drugs targeted to the fibrotic process ...
Citation: Cell & Bioscience 2022 12:203 -
Overview of the meningeal lymphatic vessels in aging and central nervous system disorders
In the aging process and central nervous system (CNS) diseases, the functions of the meningeal lymphatic vessels (MLVs) are impaired. Alterations in MLVs have been observed in aging-related neurodegenerative d...
Citation: Cell & Bioscience 2022 12:202 -
Correction: Plasma metabolomics provides new insights into the relationship between metabolites and outcomes and left ventricular remodeling of coronary artery disease
Citation: Cell & Bioscience 2022 12:201 -
Distinct mechanisms mediating therapy-induced cellular senescence in prostate cancer
Prostate cancer (PCa) is an age-related malignancy in men with a high incidence rate. PCa treatments face many obstacles due to cancer cell resistance and many bypassing mechanisms to escape therapy. According...
Citation: Cell & Bioscience 2022 12:200 -
Male guanine-rich RNA sequence binding factor 1 knockout mice (Grsf1−/−) gain less body weight during adolescence and adulthood
The guanine-rich RNA sequence binding factor 1 (GRSF1) is an RNA-binding protein of the heterogenous nuclear ribonucleoprotein H/F (hnRNP H/F) family that binds to guanine-rich RNA sequences forming G-quadrupl...
Citation: Cell & Bioscience 2022 12:199 -
Hif-2α regulates lipid metabolism in alcoholic fatty liver disease through mitophagy
Disordered lipid metabolism plays an essential role in both the initiation and progression of alcoholic fatty liver disease (AFLD), and fatty acid β-oxidation is increasingly considered as a crucial factor for...
Citation: Cell & Bioscience 2022 12:198 -
Activation of Piezo1 downregulates renin in juxtaglomerular cells and contributes to blood pressure homeostasis
The synthesis and secretion of renin in juxtaglomerular (JG) cells are closely regulated by the blood pressure. To date, however, the molecular identity through which JG cells respond to the blood pressure rem...
Citation: Cell & Bioscience 2022 12:197 -
Astrocyte derived TSP2 contributes to synaptic alteration and visual dysfunction in retinal ischemia/reperfusion injury
Despite current intervention measures/therapies are able to ameliorate neuronal death following retinal injuries/diseases, the recovery of visual function remains unsatisfactory. Previous studies revealed that...
Citation: Cell & Bioscience 2022 12:196 -
Aurora kinase a promotes the progression of papillary thyroid carcinoma by activating the mTORC2-AKT signalling pathway
Treatment failure is the main cause of death from papillary thyroid carcinoma (PTC). It is urgent to look for new intervention targets and to develop new therapies for treating PTC. Aurora-A kinase (AURKA) fun...
Citation: Cell & Bioscience 2022 12:195 -
PGCLCs of human 45,XO reveal pathogenetic pathways of neurocognitive and psychosocial disorders
Neurocognitive disorders and psychosocial difficulties are common in patients with Turner syndrome and multiple neurodegenerative diseases, yet there is no effective cure. Human primordial germ cells (hPGCs) a...
Citation: Cell & Bioscience 2022 12:194 -
In vivo genome-wide CRISPR screening identifies ZNF24 as a negative NF-κB modulator in lung cancer
Systemic identification of tumor suppressor genes (TSGs) and elucidation of their signaling provide a new angle for understanding of tumorigenesis, which is important for developing successful treatment for lu...
Citation: Cell & Bioscience 2022 12:193 -
MicroRNA-378a-3p prevents initiation and growth of colorectal cancer by fine tuning polyamine synthesis
Inhibitors of ornithine decarboxylase (ODC) are effective at preventing colorectal cancer (CRC). However, their high toxicity limits their clinical application. This study was aimed to explore the potential of...
Citation: Cell & Bioscience 2022 12:192 -
Mechanosensitive piezo1 calcium channel activates connexin 43 hemichannels through PI3K signaling pathway in bone
Mechanical loading promotes bone formation and osteocytes are a major mechanosensory cell in the bone. Both Piezo1 channels and connexin 43 hemichannels (Cx43 HCs) in osteocytes are important players in mechan...
Citation: Cell & Bioscience 2022 12:191 -
A synthetic pregnenolone analog promotes microtubule dynamics and neural development
Pregnenolone (P5) is a neurosteroid that promotes microtubule polymerization. It also reduces stress and negative symptoms of schizophrenia, promotes memory, as well as recovery from spinal cord injury. P5 is ...
Citation: Cell & Bioscience 2022 12:190 -
Proteomic signatures of schizophrenia-sourced iPSC-derived neural cells and brain organoids are similar to patients' postmortem brains
Schizophrenia is a complex and severe neuropsychiatric disorder, with a wide range of debilitating symptoms. Several aspects of its multifactorial complexity are still unknown, and some are accepted to be an e...
Citation: Cell & Bioscience 2022 12:189 -
Defb19 regulates the migration of germ cell and is involved in male fertility
β-defensins are small antimicrobial peptides that play essential roles in male fertility. Although several members of the β-defensin family are preferentially expressed in the testis, their involvement in sper...
Citation: Cell & Bioscience 2022 12:188 -
The immunological mechanisms and therapeutic potential in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity
Acute liver failure caused by drug overdose is a significant clinical problem in developed countries. Acetaminophen (APAP), a widely used analgesic and antipyretic drug, but its overdose can cause acute liver ...
Citation: Cell & Bioscience 2022 12:187 -
DNA methylation in diabetic retinopathy: pathogenetic role and potential therapeutic targets
Diabetic retinopathy (DR), a specific neuron-vascular complication of diabetes, is a major cause of vision loss among middle-aged people worldwide, and the number of DR patients will increase with the increasi...
Citation: Cell & Bioscience 2022 12:186 -
Hypoxia increases RCC stem cell phenotype via altering the androgen receptor (AR)-lncTCFL5-2-YBX1-SOX2 signaling axis
Early studies indicated that the androgen receptor (AR) could promote renal cell carcinoma (RCC) development and metastasis, but its linkage to RCC progression under hypoxia, remains unclear.
Citation: Cell & Bioscience 2022 12:185
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- ISSN: 2045-3701 (electronic)