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  1. PKM2 is an attractive target for cancer therapy, however, for many cancer cells, PKM2 knockdown only leads to a modest impairment of survival and proliferation. It is not known whether PKM2 knockdown rewires c...

    Authors: Xiaodong Qin, Yuping Du, Xing Chen, Wuyan Li, Jinghong Zhang and Jinbo Yang

    Citation: Cell & Bioscience 2014 4:20

    Content type: Short report

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  2. Iron is an important mineral element used by the body in a variety of metabolic and physiologic processes. These processes are highly active when the body is undergoing physical exercises. Prevalence of exerci...

    Authors: Wei-Na Kong, Guofen Gao and Yan-Zhong Chang

    Citation: Cell & Bioscience 2014 4:19

    Content type: Review

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  3. The human ether-a-go-go-related gene potassium channel (hERG) has an unusual long turret, whose role in recognizing scorpion toxins remains controversial. Here, BmKKx2, the first specific blocker of hERG chann...

    Authors: You-Tian Hu, Jun Hu, Tian Li, Jing-Jing Wei, Jing Feng, Yi-Mei Du, Zhi-Jian Cao, Wen-Xin Li and Ying-Liang Wu

    Citation: Cell & Bioscience 2014 4:18

    Content type: Research

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  4. Autophagy (macroautophagy), a cellular process of “self-eating”, segregates damaged/aged organelles into vesicles, fuses with lysosomes, and enables recycling of the digested materials. The precise origin(s) o...

    Authors: Katherine L Cook, David R Soto-Pantoja, Mones Abu-Asab, Pamela AG Clarke, David D Roberts and Robert Clarke

    Citation: Cell & Bioscience 2014 4:16

    Content type: Short report

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  5. To clone and express a truncated, soluble vascular endothelial growth factor receptor 2 (sVEGFR2) possessing the combined-functional domains 1–3 and 5 in eukaryotic cells and to test the inhibitory effects of ...

    Authors: Wei Liu, Xinyuan Zhang, Ching Song, Shisan Bao, Donna Lai, Jianqiu Mou, Tao Jiang and Ningli Wang

    Citation: Cell & Bioscience 2014 4:14

    Content type: Research

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  6. Human papillomavirus (HPV) infections are particularly problematic for HIV + and solid organ transplant patients with compromised CD4+ T cell-dependent immunity as they produce more severe and progressive dise...

    Authors: Shiwen Peng, Liwen Song, Jayne Knoff, Joshua W Wang, Yung-Nien Chang, Drew Hannaman, T-C Wu, Ronald D Alvarez, Richard BS Roden and Chien-Fu Hung

    Citation: Cell & Bioscience 2014 4:11

    Content type: Research

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  7. Autophagy1 is a complex of adaptive cellular response that enhances cancer cell survival in the face of cellular stresses such as chemothery. Here we show that in human gallbladder carcinoma (GBC) cells lines,...

    Authors: Xiao Liang, JiaCheng Tang, YueLong Liang, RenAn Jin and XiuJun Cai

    Citation: Cell & Bioscience 2014 4:10

    Content type: Research

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  8. The human TSPY is the putative gene for the gonadoblastoma locus on the Y chromosome (GBY). Various molecular, pathological and transgenic mouse studies suggest that TSPY is a Y-located proto-oncogene contributin...

    Authors: Tatsuo Kido, Stephanie Schubert, Shingo Hatakeyama, Chikara Ohyama, Jörg Schmidtke and Yun-Fai Chris Lau

    Citation: Cell & Bioscience 2014 4:9

    Content type: Research

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  9. Induction of Nrf2-mediated detoxifying/antioxidant genes has been recognized as an effective strategy for cancer chemoprevention. Si-Wu-Tang (SWT), comprising the combination of four herbs, Paeoniae, Angelicae...

    Authors: Mandy Liu, Ranadheer Ravula, Zhijun Wang, Zhong Zuo, Moses SS Chow, Arvind Thakkar, Sunil Prabhu, Bradley Andresen and Ying Huang

    Citation: Cell & Bioscience 2014 4:8

    Content type: Research

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  10. A great challenge of cancer chemotherapy is to eliminate cancer cells and concurrently maintain the quality of life (QOL) for cancer patients. Previously, we identified a novel anti-cancer bioactive peptide (A...

    Authors: Xiulan Su, Chao Dong, Jialing Zhang, Liya Su, Xuemei Wang, Hongwei Cui and Zhong Chen

    Citation: Cell & Bioscience 2014 4:7

    Content type: Research

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  11. Interleukin-6 (IL-6) has been shown to be vital for liver regeneration, however the specific mechanisms and factors involved remain incompletely defined. The present study aimed to investigate whether IL-6 exe...

    Authors: Shingo Tachibana, Xiuying Zhang, Kazushige Ito, Yoshihiro Ota, Andrew M Cameron, George Melville Williams and Zhaoli Sun

    Citation: Cell & Bioscience 2014 4:6

    Content type: Research

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  12. The editors of Cell & Bioscience would like to thank all the reviewers who contributed to the journal in Volume 3 (2013).

    Authors: Yun-Bo Shi

    Citation: Cell & Bioscience 2014 4:4

    Content type: Reviewer acknowledgement

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  13. Genome variations in human papillomaviruses (HPVs) are common and have been widely investigated in the past two decades. HPV genotyping depends on the finding of the viral genome variations in the L1 ORF. Othe...

    Authors: Xiaohong Wang, Yang Li, Ting Ni, Xing Xie, Jun Zhu and Zhi-Ming Zheng

    Citation: Cell & Bioscience 2014 4:5

    Content type: Research

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  14. Whereas severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) is associated with severe disease, human coronavirus HKU1 (HCoV-HKU1) commonly circulates in the human populations causing generally mild...

    Authors: Kam-Leung Siu, Ching-Ping Chan, Kin-Hang Kok, Patrick C-Y Woo and Dong-Yan Jin

    Citation: Cell & Bioscience 2014 4:3

    Content type: Research

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  15. Abnormal and uncontrolled proliferation of lung fibroblasts may contribute to pulmonary fibrosis. Lipopolysaccharide (LPS) can induce fibroblast proliferation and differentiation through activation of phosphoi...

    Authors: Zhengyu He, Yuxiao Deng, Wen Li, Yongming Chen, Shunpeng Xing, Xianyuan Zhao, Jia Ding, Yuan Gao and Xiangrui Wang

    Citation: Cell & Bioscience 2014 4:2

    Content type: Research

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  16. There is an urgent need to develop targeted therapies for the control of advanced stage ovarian cancer because it is the most deadly gynecologic cancer. Antigen-specific immunotherapy is a promising approach b...

    Authors: Tae Heung Kang, Jayne Knoff, Benjamin Yang, Ya-Chea Tsai, Liangmei He, Chien-Fu Hung and T-C Wu

    Citation: Cell & Bioscience 2013 3:48

    Content type: Research

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  17. Type 1 and type 2 diabetes are characterized by loss of β-cells; therefore, β-cell regeneration has become one of the primary approaches to diabetes therapy. Resveratrol, a naturally occurring polyphenolic com...

    Authors: Sherwin Xie, Rohit Anthony Sinha, Brijesh K Singh, Guo Dong Li, Weiping Han and Paul M Yen

    Citation: Cell & Bioscience 2013 3:47

    Content type: Short report

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  18. Accumulating evidences have identified the immunoregulatory features of stem cells. In this study, the immunoregulation of bone marrow-derived stem cells (BMSCs) transplanted into patients with HBV-related dec...

    Authors: Linhua Zheng, Jindong Chu, Yongquan Shi, Xinmin Zhou, Ling Tan, Qiang Li, Lina Cui, Zheyi Han, Ying Han and Daiming Fan

    Citation: Cell & Bioscience 2013 3:46

    Content type: Research

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  19. The sorting nexin (SNX) family is involved in endocytosis and protein trafficking and plays multiple roles in various diseases. The role of SNX proteins in Kawasaki disease (KD) is not known. We attempted to t...

    Authors: Ying-Ju Lin, Jeng-Sheng Chang, Xiang Liu, Ting-Hsu Lin, Shao-Mei Huang, Chiu-Chu Liao, Cheng-Wen Lin, Wen-Kuei Chien, Jin-Hua Chen, Jer-Yuarn Wu, Chien-Hsiun Chen, Li-Ching Chang, Hsinyi Tsang, Kuan-Teh Jeang, Chia-Yen Chen and Fuu-Jen Tsai

    Citation: Cell & Bioscience 2013 3:44

    Content type: Research

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  20. Organ-specific, adult stem cells are essential for organ-homeostasis and tissue repair and regeneration. The formation of such stem cells during vertebrate development remains to be investigated. Frog metamorp...

    Authors: Nga Luu, Luan Wen, Liezhen Fu, Kenta Fujimoto, Yun-Bo Shi and Guihong Sun

    Citation: Cell & Bioscience 2013 3:43

    Content type: Research

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  21. Adult stem cells maintain tissue homeostasis by their ability to both self-renew and differentiate to distinct cell types. Multiple signaling pathways have been shown to play essential roles as extrinsic cues ...

    Authors: Lama Tarayrah and Xin Chen

    Citation: Cell & Bioscience 2013 3:41

    Content type: Review

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  22. Our previous research demonstrated that one subcutaneous injection of 17-Dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG) 24 hours (h) before irradiation (8.75 Gy) increased mouse survival by 75%. Ho...

    Authors: Xinyue Lu, Dilber Nurmemet, David L Bolduc, Thomas B Elliott and Juliann G Kiang

    Citation: Cell & Bioscience 2013 3:36

    Content type: Research

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  23. Autophagy serves as a dynamic degradation and recycling system that provides biological materials and energy in response to stress. The role of autophagy in tumor development is complex. Various studies sugges...

    Authors: Kai Sun, Weijie Deng, Shanshan Zhang, Ning Cai, Shufan Jiao, Jianrui Song and Lixin Wei

    Citation: Cell & Bioscience 2013 3:35

    Content type: Review

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  24. The Hippo signaling pathway has emerged as a critical regulator for organ size control. The serine/threonine protein kinases Mst1 and Mst2, mammalian homologs of the Hippo kinase from Drosophila, play the cent...

    Authors: Funiu Qin, Jing Tian, Dawang Zhou and Lanfen Chen

    Citation: Cell & Bioscience 2013 3:31

    Content type: Review

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  25. Merkel cell polyomavirus (MCPyV) is a DNA virus expressing transcripts similar to the large T (LT) and small T (ST) transcripts of SV40, which has been implicated in the pathogenesis of Merkel cell carcinoma (...

    Authors: Bianca Gomez, Liangmei He, Ya Chea Tsai, T-C Wu, Raphael P Viscidi and Chien-Fu Hung

    Citation: Cell & Bioscience 2013 3:29

    Content type: Research

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  26. The previous investigation demonstrated the radioprotective efficacy of peptides isolated from the venom of Buthus Martti Karsch. In this study, the effect of isolated scorpion venom peptide II (SVPII) on irradia...

    Authors: Yifang Qiu, Liyuan Jiang, Caixia Wang, Yan Wang, Ting Li, Baiqian Xing, Meixun Zhou, Tianhan Kong and Weihua Dong

    Citation: Cell & Bioscience 2013 3:28

    Content type: Research

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  27. Hemicentin has come a long way from when it was first identified in C. elegans as him-4 (High incidence of males). The protein is now a recognized player in maintaining the architectural integrity of vertebrate t...

    Authors: Xuehong Xu, MengMeng Xu, Xin Zhou, Odell B Jones, Edward Moharomd, Yuexin Pan, Guifang Yan, Donald D Anthony and Williams B Isaacs

    Citation: Cell & Bioscience 2013 3:27

    Content type: Review

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  28. Hepatic ischemia/reperfusion is a multi-factorial process which causes liver injury. It is reported that ischemia alone is sufficient to induce liver injury. Nutrient deprivation is a crucial factor impacting ...

    Authors: Kai Sun, Xuqin Xie, Yan Liu, Zhipeng Han, Xue Zhao, Ning Cai, Shanshan Zhang, Jianrui Song and Lixin Wei

    Citation: Cell & Bioscience 2013 3:26

    Content type: Research

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  29. Transcription activator-like effector nucleases (TALENs) are novel engineered DNA nucleases, and have been proven to be effective for gene specific targeting in various species. Recently we reported gene disru...

    Authors: Yong Lei, Xiaogang Guo, Yi Deng, Yonglong Chen and Hui Zhao

    Citation: Cell & Bioscience 2013 3:21

    Content type: Review

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