Articles
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Citation: Cell & Bioscience 2022 12:146
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Unraveled roles of Cav1.2 in proliferation and stemness of ameloblastoma
Transcriptome analysis has been known as a functional tool for cancer research recently. Mounting evidence indicated that calcium signaling plays several key roles in cancer progression. Despite numerous studi...
Citation: Cell & Bioscience 2022 12:145 -
Correction to: Hepatitis, testicular degeneration, and ataxia in DIDO3-deficient mice with altered mRNA processing
Citation: Cell & Bioscience 2022 12:144 -
Induced hepatic stem cells maintain self-renewal through the high expression of Myc coregulated by TET1 and CTCF
Induced hepatic stem cells (iHepSCs) with the capacities of self-renewal and bidifferentiation into hepatocytes and cholangiocytes were generated from mouse embryonic fibroblasts (MEFs) by lineage reprogrammin...
Citation: Cell & Bioscience 2022 12:143 -
scMTD: a statistical multidimensional imputation method for single-cell RNA-seq data leveraging transcriptome dynamic information
Single-cell RNA sequencing (scRNA-seq) provides a powerful tool to capture transcriptomes at single-cell resolution. However, dropout events distort the gene expression levels and underlying biological signals...
Citation: Cell & Bioscience 2022 12:142 -
E-cadherin maintains the undifferentiated state of mouse spermatogonial progenitor cells via β-catenin
Cadherins play a pivotal role in facilitating intercellular interactions between spermatogonial progenitor cells (SPCs) and their surrounding microenvironment. Specifically, E-cadherin serves as a cellular mar...
Citation: Cell & Bioscience 2022 12:141 -
Motoneurons innervation determines the distinct gene expressions in multinucleated myofibers
Neuromuscular junctions (NMJs) are peripheral synapses connecting motoneurons and skeletal myofibers. At the postsynaptic side in myofibers, acetylcholine receptor (AChR) proteins are clustered by the neuronal...
Citation: Cell & Bioscience 2022 12:140 -
TRIM22 suppresses Zika virus replication by targeting NS1 and NS3 for proteasomal degradation
Recognition of viral invasion by innate antiviral immune system triggers activation of the type I interferon (IFN-I) and proinflammatory signaling pathways. Subsequently, IFN-I induction regulates expression o...
Citation: Cell & Bioscience 2022 12:139 -
Correction: New insights into fibrosis from the ECM degradation perspective: the macrophage-MMP-ECM interaction
Citation: Cell & Bioscience 2022 12:138 -
Retraction Note to: Universal minicircle sequence binding protein of Leishmania donovani regulates pathogenicity by controlling expression of cytochrome-b
Citation: Cell & Bioscience 2022 12:137 -
CDKN2AIP is critical for spermiogenesis and germ cell development
As a member of RNA-binding protein, CDKN2AIP has been shown to play a critical role in stem cell pluripotency and somatic differentiation. Recent studies indicate that Cdkn2aip is essential for spermatogonial sel...
Citation: Cell & Bioscience 2022 12:136 -
Anti-tumor effects of dual PI3K-HDAC inhibitor CUDC-907 on activation of ROS-IRE1α-JNK-mediated cytotoxic autophagy in esophageal cancer
PI3K-Akt pathway activation and the expression of histone deacetylases (HDACs) are highly increased in esophageal cancer, suggesting that inhibition of such targets may be a viable therapeutic strategy. Herein...
Citation: Cell & Bioscience 2022 12:135 -
Inhibition of the cardiac fibroblast-enriched histone methyltransferase Dot1L prevents cardiac fibrosis and cardiac dysfunction
Cardiac fibrosis is characterized by excessive extracellular matrix deposition that contributes to compromised cardiac function and potentially heart failure. Disruptor of telomeric silencing 1-like (Dot1L) is...
Citation: Cell & Bioscience 2022 12:134 -
Melatonin inhibits NaIO3-induced ARPE-19 cell apoptosis via suppression of HIF-1α/BNIP3-LC3B/mitophagy signaling
Age-related macular degeneration (AMD) leads to gradual central vision loss and eventual irreversible blindness. Melatonin, an endogenous hormone, exhibits anti-inflammatory and antitumor effects; however, the...
Citation: Cell & Bioscience 2022 12:133 -
Urological cancer organoids, patients' avatars for precision medicine: past, present and future
Urological cancers are common malignant cancers worldwide, with annually increasing morbidity and mortality rates. For decades, two-dimensional cell cultures and animal models have been widely used to study th...
Citation: Cell & Bioscience 2022 12:132 -
Presenilin-1 F105C mutation leads to tau accumulation in human neurons via the Akt/mTORC1 signaling pathway
The mammalian target of rapamycin (mTOR) plays a critical role in controlling cellular homeostasis, and its dysregulation has been implicated in Alzheimer’s disease (AD). Presenilin-1 (PS1) mutations account f...
Citation: Cell & Bioscience 2022 12:131 -
OpenVar: functional annotation of variants in non-canonical open reading frames
Recent technological advances have revealed thousands of functional open reading frames (ORF) that have eluded reference genome annotations. These overlooked ORFs are found throughout the genome, in any readin...
Citation: Cell & Bioscience 2022 12:130 -
Functions and mechanisms of protein disulfide isomerase family in cancer emergence
The endoplasmic reticulum (ER) is a multi-layered organelle that is essential for the synthesis, folding, and structural maturation of almost one-third of the cellular proteome. It houses several resident prot...
Citation: Cell & Bioscience 2022 12:129 -
D-dopachrome tautomerase drives astroglial inflammation via NF-κB signaling following spinal cord injury
Reactive astrocytes are increasingly recognized as crucial regulators of innate immunity in degenerative or damaged central nervous system (CNS). Many proinflammatory mediators have been shown to drive inflamm...
Citation: Cell & Bioscience 2022 12:128 -
Osteoclast-derived extracellular vesicles are implicated in sensory neurons sprouting through the activation of epidermal growth factor signaling
Different pathologies, affecting the skeletal system, were reported to display altered bone and/or cartilage innervation profiles leading to the deregulation of the tissue homeostasis. The patterning of periph...
Citation: Cell & Bioscience 2022 12:127 -
Current methodologies in protein ubiquitination characterization: from ubiquitinated protein to ubiquitin chain architecture
Ubiquitination is a versatile post-translational modification (PTM), which regulates diverse fundamental features of protein substrates, including stability, activity, and localization. Unsurprisingly, dysregu...
Citation: Cell & Bioscience 2022 12:126 -
N6-methyladenosine-mediated CELF2 regulates CD44 alternative splicing affecting tumorigenesis via ERAD pathway in pancreatic cancer
Alternative splicing (AS) of genes has been found to affect gene stability, and its abnormal regulation can lead to tumorigenesis. CELF2 is a vital splicing factor to participate in mRNA alternative splicing. ...
Citation: Cell & Bioscience 2022 12:125 -
IFITM3 promotes malignant progression, cancer stemness and chemoresistance of gastric cancer by targeting MET/AKT/FOXO3/c-MYC axis
Targeting the HGF/MET signaling pathway has been a viable therapeutic strategy for various cancer types due to hyperactivation of HGF/MET axis occurs frequently that leads to detrimental cancer progression and...
Citation: Cell & Bioscience 2022 12:124 -
GREM1/PPP2R3A expression in heterogeneous fibroblasts initiates pulmonary fibrosis
Fibroblasts have important roles in the synthesis and remodeling of extracellular matrix (ECM) proteins during pulmonary fibrosis. However, the spatiotemporal distribution of heterogeneous fibroblasts during d...
Citation: Cell & Bioscience 2022 12:123 -
AKT phosphorylation as a predictive biomarker for PI3K/mTOR dual inhibition-induced proteolytic cleavage of mTOR companion proteins in small cell lung cancer
Constitutive activation of PI3K signaling has been well recognized in a subset of small cell lung cancer (SCLC), the cancer type which has the most aggressive clinical course amongst pulmonary tumors. Whereas ...
Citation: Cell & Bioscience 2022 12:122 -
Tick-borne encephalitis affects sleep–wake behavior and locomotion in infant rats
Tick-borne encephalitis (TBE) is a disease affecting the central nervous system. Over the last decade, the incidence of TBE has steadily increased in Europe and Asia despite the availably of effective vaccines...
Citation: Cell & Bioscience 2022 12:121 -
LncRNA CRLM1 inhibits apoptosis and promotes metastasis through transcriptional regulation cooperated with hnRNPK in colorectal cancer
Colorectal liver metastases (CRLM) continue to have a low survival rate. The number of CRLM regulators and clinical indicators remains limited. Long non-coding RNAs (lncRNAs) are a new master regulator of cell...
Citation: Cell & Bioscience 2022 12:120 -
Oxysterol derivatives Oxy186 and Oxy210 inhibit WNT signaling in non-small cell lung cancer
Developmental signaling pathways such as those of Hedgehog (HH) and WNT play critical roles in cancer stem cell self-renewal, migration, and differentiation. They are often constitutively activated in many hum...
Citation: Cell & Bioscience 2022 12:119 -
Arcuate AgRP, but not POMC neurons, modulate paraventricular CRF synthesis and release in response to fasting
The activation of the hypothalamic–pituitary–adrenal (HPA) axis is essential for metabolic adaptation in response to fasting. However, the neurocircuitry connecting changes in the peripheral energy stores to t...
Citation: Cell & Bioscience 2022 12:118 -
New insights into fibrosis from the ECM degradation perspective: the macrophage-MMP-ECM interaction
Fibrosis is a pathological feature of a variety of chronic inflammatory diseases that can affect almost all organs, which can cause severe consequences and even lead to death. Fibrosis is characterized by the ...
Citation: Cell & Bioscience 2022 12:117 -
cGAS inhibition alleviates Alu RNA-induced immune responses and cytotoxicity in retinal pigmented epithelium
The degeneration of retinal pigmented epithelium (RPE) cells results in severe diseases, such as age-related macular degeneration (AMD) that causes blindness in millions of individuals.
Citation: Cell & Bioscience 2022 12:116 -
Single-cell RNA sequencing reveals the potential mechanism of heterogeneity of immunomodulatory properties of foreskin and umbilical cord mesenchymal stromal cells
Mesenchymal stromal cells (MSCs) are heterogeneous populations. Heterogeneity exists within the same tissue and between different tissues. Some studies have found enormous heterogeneity in immunomodulatory fun...
Citation: Cell & Bioscience 2022 12:115 -
Neutrophil extracellular traps promote thrombogenicity in cerebral venous sinus thrombosis
Neutrophil extracellular traps (NETs) contribute to the creation of a coagulation state in various diseases. Currently, it is not clear whether NETs are present in the thrombi and plasma of patients with cereb...
Citation: Cell & Bioscience 2022 12:114 -
SENP6 induces microglial polarization and neuroinflammation through de-SUMOylation of Annexin-A1 after cerebral ischaemia–reperfusion injury
Previous data have reported that Sentrin/SUMO-specific protease 6 (SENP6) is involved in ischaemic brain injury and induces neuronal apoptosis after cerebral ischaemia, but the role of SENP6 in microglia-induc...
Citation: Cell & Bioscience 2022 12:113 -
Regulatory T cells-centered regulatory networks of skeletal muscle inflammation and regeneration
As the understanding of skeletal muscle inflammation is increasingly clarified, the role of Treg cells in the treatment of skeletal muscle diseases has attracted more attention in recent years. A consensus has...
Citation: Cell & Bioscience 2022 12:112 -
Myometrial oxidative stress drives MED12 mutations in leiomyoma
More than 70% of leiomyomas (LM) harbor MED12 mutations, primarily in exon 2 at c.130-131(GG). The cause of MED12 mutations in myometrial cells remains largely unknown. We hypothesized that increased ROS promotes...
Citation: Cell & Bioscience 2022 12:111 -
FBXL17/spastin axis as a novel therapeutic target of hereditary spastic paraplegia
Spastin significantly influences microtubule regulation in neurons and is implicated in the pathogenesis of hereditary spastic paraplegia (HSP). However, post-translational regulation of the spastin protein re...
Citation: Cell & Bioscience 2022 12:110 -
Siglec-15-induced autophagy promotes invasion and metastasis of human osteosarcoma cells by activating the epithelial–mesenchymal transition and Beclin-1/ATG14 pathway
Pulmonary metastasis is the main cause of poor prognosis in osteosarcoma. Sialic acid-bound immunoglobulin lectin 15 (Siglec-15) has been demonstrated to be obviously correlated with pulmonary metastasis in os...
Citation: Cell & Bioscience 2022 12:109 -
A novel and atypical NF-KB pro-inflammatory program regulated by a CamKII-proteasome axis is involved in the early activation of Muller glia by high glucose
Diabetic retinopathy (DR) is a microvascular complication of diabetes with a heavy impact on the quality of life of subjects and with a dramatic burden for health and economic systems on a global scale. Althou...
Citation: Cell & Bioscience 2022 12:108 -
Transcriptomic analysis reveals the key role of histone deacetylation via mediating different phytohormone signalings in fiber initiation of cotton
Histone deacetylation is one of the most important epigenetic modifications and plays diverse roles in plant development. However, the detailed functions and mechanisms of histone deacetylation in fiber develo...
Citation: Cell & Bioscience 2022 12:107 -
Lipid metabolism and storage in neuroglia: role in brain development and neurodegenerative diseases
The importance of neuroglia in maintaining normal brain function under physiological and pathological conditions has been supported by growing evidence in recent years. The most important issues regarding glia...
Citation: Cell & Bioscience 2022 12:106 -
Human skin dermis-derived fibroblasts are a kind of functional mesenchymal stromal cells: judgements from surface markers, biological characteristics, to therapeutic efficacy
Human mesenchymal stromal cells (MSCs) have been widely advocated to clinical use. Human skin dermis-derived fibroblasts shared similar cellular morphology and biological characteristics to MSCs, while it stil...
Citation: Cell & Bioscience 2022 12:105 -
Expanding the CRISPR/Cas genome-editing scope in Xenopus tropicalis
The true diploid frog, Xenopus tropicalis (X. tropicalis) is an excellent genetic model organism. To date, the CRISPR/Cas-mediated genome editing methods established in this species are mostly based on SpCas9 tha...
Citation: Cell & Bioscience 2022 12:104 -
Neuropathy-associated Fars2 deficiency affects neuronal development and potentiates neuronal apoptosis by impairing mitochondrial function
Neurodegenerative diseases encompass an extensive and heterogeneous group of nervous system disorders which are characterized by progressive degeneration and death of neurons. Many lines of evidence suggest th...
Citation: Cell & Bioscience 2022 12:103 -
Metabolomics of blood reveals age-dependent pathways in Parkinson’s Disease
Parkinson’s Disease (PD) is the second most frequent degenerative disorder, the risk of which increases with age. A preclinical PD diagnostic test does not exist. We identify PD blood metabolites and metabolic...
Citation: Cell & Bioscience 2022 12:102 -
Advancing equity through strengthening research on health and well-being of Asian American, Native Hawaiian, and Pacific Islander
The National Institutes of Health’s Asian American, Native Hawaiian and Pacific Islander Health Scientific Interest Group (NIH AANHPI-HSIG) provides a viewpoint on developing approaches to enhance research on ...
Citation: Cell & Bioscience 2022 12:101 -
Editorial Expression of Concern: Ginkgetin aglycone ameliorates LPS-induced acute kidney injury by activating SIRT1 via inhibiting the NF-κB signaling pathway
Citation: Cell & Bioscience 2022 12:100 -
Novel insights into non-alcoholic fatty liver disease and dementia: insulin resistance, hyperammonemia, gut dysbiosis, vascular impairment, and inflammation
Non-alcoholic fatty liver disease (NAFLD) is a metabolic disease characterized by multiple pathologies. The progression of dementia with NAFLD may be affected by various risk factors, including brain insulin r...
Citation: Cell & Bioscience 2022 12:99 -
DNA methyltransferase 1 knockdown reverses PTEN and VDR by mediating demethylation of promoter and protects against renal injuries in hepatitis B virus-associated glomerulonephritis
Aberrant DNA methylation patterns, including hypermethylation of key genes that inhibit fibrosis and inflammation, have been described in human kidney diseases. However, the role of DNA methyltransferase 1 (DN...
Citation: Cell & Bioscience 2022 12:98 -
Biological functions, mechanisms, and clinical significance of circular RNA in pancreatic cancer: a promising rising star
Pancreatic cancer (PC) is a highly malignant solid tumor with insidious onset and easy early metastasis. Despite tremendous efforts devoted to research in this field, the mechanisms underlying PC tumorigenesis...
Citation: Cell & Bioscience 2022 12:97
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- ISSN: 2045-3701 (electronic)