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  1. Research involving antimitotic compounds identified 2-methoxyestradiol (2ME2), as a promising anticancer endogenous metabolite. Owing to its low bioavailability, several in silico-designed 2ME2 analogues were syn...

    Authors: Michelle Helen Visagie, Lyn-Marie Birkholtz and Anna Margaretha Joubert

    Citation: Cell & Bioscience 2015 5:19

    Content type: Research

    Published on:

  2. Cellular antiviral activities are critically controlled by transcriptional activation of interferon-inducible genes, involving interferon regulatory factors (IRFs). Previous data suggested that IRF1 is an acti...

    Authors: Gang Ren, Kairong Cui, Zhiying Zhang and Keji Zhao

    Citation: Cell & Bioscience 2015 5:17

    Content type: Research

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  3. Aedes albopictus is an important vector of Dengue virus (DENV) and it has quickly invaded the tropical and temperate environments worldwide. A few studies have shown that, microRNAs (miRNAs) re...

    Authors: Yanxia Liu, Yanhe Zhou, Jinya Wu, Peiming Zheng, Yiji Li, Xiaoying Zheng, Santhosh Puthiyakunnon, Zhijian Tu and Xiao-Guang Chen

    Citation: Cell & Bioscience 2015 5:16

    Content type: Research

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  4. Development of a tumor is a very complex process, and invasion and metastasis of malignant tumors are hallmarks and are difficult problems to overcome. The tumor microenvironment plays an important role in con...

    Authors: Xue Yang, Dan-Dan Yu, Fei Yan, Ying-Ying Jing, Zhi-Peng Han, Kai Sun, Lei Liang, Jing Hou and Li-Xin Wei

    Citation: Cell & Bioscience 2015 5:14

    Content type: Review

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  5. Intestinal remodeling during amphibian metamorphosis has long been studied as a model for the formation of the adult organs in vertebrates, especially the formation of adult organ-specific stem cells. Like all...

    Authors: Luan Wen, Takashi Hasebe, Thomas C Miller, Atsuko Ishizuya-Oka and Yun-Bo Shi

    Citation: Cell & Bioscience 2015 5:13

    Content type: Research

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  6. Growth hormone secretagogue receptor (GHSR) and its ligand, ghrelin, are important modulators in weight control and energy homeostasis. Recently, ghrelin is also involved in experimental colitis, but the role ...

    Authors: Zhen-ze Liu, Wei-gang Wang, Qing Li, Miao Tang, Jun Li, Wen-ting Wu, Ying-han Wan, Zhu-gang Wang, Shi-san Bao and Jian Fei

    Citation: Cell & Bioscience 2015 5:12

    Content type: Research

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  7. The physiological and pathological roles of hydrogen sulfide (H2S) in the regulation of cardiovascular functions have been recognized. Cystathionine gamma-lyase (CSE) is a major H2S-producing enzyme in cardiovasc...

    Authors: Hongzhu Li, Yuehong Wang, Can Wei, Shuzhi Bai, Yajun Zhao, Hongxia Li, Bo Wu, Rui Wang, Lingyun Wu and Changqing Xu

    Citation: Cell & Bioscience 2015 5:11

    Content type: Research

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  8. The INT6 gene was first discovered as a site of integration in mouse mammary tumors by the mouse mammary tumor virus; however, INT6’s role in the development of human breast cancer remains largely unknown. By gen...

    Authors: Jinfeng Suo, Daniel Medina, Sabrina Herrera, Ze-Yi Zheng, Lei Jin, Gary C Chamness, Alejandro Contreras, Carolina Gutierrez, Susan Hilsenbeck, Arzu Umar, John A Foekens, Samir Hanash, Rachel Schiff, Xiang H-F Zhang and Eric C Chang

    Citation: Cell & Bioscience 2015 5:10

    Content type: Research

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  9. The T790M mutation of epithelial growth factor receptor (EGFR) is a major cause of the acquired resistance to EGFR tyrosine kinase inhibitor (EGFR-TKIs) treatment for lung cancer patients. The Hippo pathway ef...

    Authors: Wei Xu, Yunyan Wei, Shuangshuang Wu, Yun Wang, Zhen Wang, Yu Sun, Steven Y Cheng and Jianqing Wu

    Citation: Cell & Bioscience 2015 5:7

    Content type: Research

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  10. Radiotherapy is widely used to treat cancer alone or in combination with surgery, chemotherapy, and immunotherapy. However, damage to normal tissues and radioresistance of tumor cells are major obstacles to su...

    Authors: Mi-Hyoung Kim, Seung-Youn Jung, Jiyeon Ahn, Sang-Gu Hwang, Hee-Jong Woo, Sungkwan An, Seon Young Nam, Dae-Seog Lim and Jie-Young Song

    Citation: Cell & Bioscience 2015 5:2

    Content type: Research

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  11. Skin tissue homeostasis is maintained by a balance between the proliferation and differentiation of epidermal stem cells (EpSCs). EpSC proliferation and differentiation are complex processes regulated by many ...

    Authors: Peng Cheng, Xuying Sun, Delong Yin, Fei Xu, Kaixiang Yang, Liang Qin, Yonghui Dong, Fengjing Guo, Anmin Chen, Weikai Zhang and Hui Huang

    Citation: Cell & Bioscience 2015 5:5

    Content type: Research

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  12. Both apoptosis and caspase-3 activity in adipose tissue-derived stem cells play an important role in the therapeutic process of diabetes patients. The purpose of this study was to investigate the effect of adv...

    Authors: Zhe Wang, Hongqiu Li, Dianbao Zhang, Xiaoyu Liu, Feng Zhao, Xining Pang and Qiushi Wang

    Citation: Cell & Bioscience 2015 5:3

    Content type: Research

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  13. Autophagy is an evolutionarily conserved cellular process that involves the lysosomal degradation of proteins and organelles and the recycling of cellular components to ensure cellular survival under external ...

    Authors: Haiqing Wang, Ting Liu, Lu Li, Qin Wang, Chunrong Yu, Xin Liu and Wenhua Li

    Citation: Cell & Bioscience 2015 5:4

    Content type: Research

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  14. Our laboratory previously reported interesting rods 3–10 μm long and rings 2–5 μm diameter (RR) in the cytoplasm of mammalian cells. Experimental evidence show that both inosine-5'-monophosphate dehydrogenase ...

    Authors: Gerson Dierley Keppeke, Luís Eduardo C Andrade, Scott S Grieshaber and Edward K L Chan

    Citation: Cell & Bioscience 2015 5:1

    Content type: Research

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  15. Sanguis draxonis (SD), also known as “Dragon’s Blood”, is a traditional herb medicine that has been used to treat a variety of complications with unknown mechanisms. Recent studies show that SD displays immunosup...

    Authors: Shijin Yin, Qinglan Hu, Jialie Luo, Yuxin Li, Chunlan Lu, Xuan Chen and Hongzhen Hu

    Citation: Cell & Bioscience 2014 4:78

    Content type: Research

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  16. RNA-binding protein Translocated in LipoSarcoma/FUsed Sarcoma (TLS/FUS) is one of causative genes for familial amyotrophic lateral sclerosis (ALS). We previously identified that TLS was associated with protein...

    Authors: Kenta Fujimoto and Riki Kurokawa

    Citation: Cell & Bioscience 2014 4:77

    Content type: Research

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  17. Golgi protein-73 (GP73) is a Golgi transmembrane glycoprotein elevated in numerous liver diseases. Clinically, GP73 is strongly elevated in the serum of HCC patients and is thus regarded as a novel potential b...

    Authors: Fang Wang, Qi Long, Yu Gong, Longbo Hu, Hong Zhang, Peter Oettgen and Tao Peng

    Citation: Cell & Bioscience 2014 4:76

    Content type: Research

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  18. X chromosome inactivation (XCI) is a dosage compensation mechanism that silences the majority of genes on one X chromosome in each female cell via a random process. Skewed XCI is relevant to many diseases, but...

    Authors: Yumei Luo, Jieliang Li, Detu Zhu, Yong Fan, Shaoying Li and Xiaofang Sun

    Citation: Cell & Bioscience 2014 4:74

    Content type: Research

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  19. IL-25 is emerging as a key regulator of inflammation in the intestinal mucosa because of its ability to promote type 2 while suppressing Th1 and Th17 responses. Several previous studies reported inconsistent r...

    Authors: An-Jiang Wang, Allen Smith, Yanfei Li, Joseph F Urban Jr, Thirumalai R Ramalingam, Thomas A Wynn, Nonghua Lu, Terez Shea-Donohue, Zhonghan Yang and Aiping Zhao

    Citation: Cell & Bioscience 2014 4:72

    Content type: Research

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  20. Ceramides are a class of sphingolipids that form the structural component of the cell membrane and also act as second messengers in cell signaling pathways. Emerging results suggest that ceramide induces growt...

    Authors: Zhe Liu, Yichao Xia, Bo Li, Hui Xu, Chenxing Wang, Ying Liu, Yi Li, Chunjie Li, Ning Gao and Longjiang Li

    Citation: Cell & Bioscience 2014 4:71

    Content type: Research

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  21. Chemical crosslinking is the most straightforward method to produce bispecific antibodies (BsAb) for arming ex vivo activated cytotoxic T lymphocytes. However, heterogeneous polymers are produced by chemical cros...

    Authors: Qingzhong He, Haisong Zhang, Youzhao Wang, Hong Hoi Ting, Wenhua Yu, Xuetao Cao and Wei Ge

    Citation: Cell & Bioscience 2014 4:70

    Content type: Research

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  22. Past and recent findings on tumor heterogeneity have led clinicians and researchers to broadly define cancer development as an evolving process. This evolutionary model of tumorigenesis has largely been shaped...

    Authors: Victoria R Zellmer and Siyuan Zhang

    Citation: Cell & Bioscience 2014 4:69

    Content type: Review

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  23. 2-Ethyl-3-O-sulphamoyl-estra-1,3,5(10)16-tetraene (ESE-16) is a unique, in silico-designed compound with possible anticancer properties, which were identified in our laboratory. This compound is capable of interf...

    Authors: Elize Wolmarans, Katherine Sippel, Robert McKenna and Annie Joubert

    Citation: Cell & Bioscience 2014 4:68

    Content type: Research

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  24. Patients with Kawasaki disease (KD), a pediatric systemic vasculitis, may develop coronary artery aneurysm (CAA) as a complication. To investigate the role of glutamate receptors in KD and its CAA development,...

    Authors: Ying-Ju Lin, Jeng-Sheng Chang, Xiang Liu, Hsinyi Tsang, Ting-Hsu Lin, Chiu-Chu Liao, Shao-Mei Huang, Wen-Kuei Chien, Jin-Hua Chen, Jer-Yuarn Wu, Chien-Hsiun Chen, Li-Ching Chang, Cheng-Wen Lin, Tsung-Jung Ho and Fuu-Jen Tsai

    Citation: Cell & Bioscience 2014 4:67

    Content type: Research

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  25. Mounting evidence supports the role of hydrogen peroxide (H2O2) in physiological signaling as well as pathological conditions. However, the subtleties of peroxide-mediated signaling are not well understood, in pa...

    Authors: Hengchang Guo, Hossein Aleyasin, Bryan C Dickinson, Renée E Haskew-Layton and Rajiv R Ratan

    Citation: Cell & Bioscience 2014 4:64

    Content type: Review

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  26. Drosophila melanogaster has been a classic model organism for the studies of genetics. More than 15,000 Drosophila genes have been annotated since the entire genome was sequenced; however, many of them still lack...

    Authors: Shih-Ching Lin, Yu-Yun Chang and Chih-Chiang Chan

    Citation: Cell & Bioscience 2014 4:63

    Content type: Review

    Published on:

  27. MicroRNAs (miRNAs) are endogenous, small non-coding RNAs that play important roles in multiple biological processes. MiR-20b has been reported to participate in breast cancer tumorigenic progression, however, ...

    Authors: Weidong Zhou, Guixiu Shi, Qiuyan Zhang, Qiuwan Wu, Boan Li and Zhiming Zhang

    Citation: Cell & Bioscience 2014 4:62

    Content type: Research

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  28. The transactivator of transcription (Tat) protein of human immunodeficiency virus type 1 (HIV-1) is known to undergo ubiquitination. However, the roles of ubiquitination in regulating Tat stability and activit...

    Authors: Linlin Zhang, Juan Qin, Yuanyuan Li, Jian Wang, Qianqian He, Jun Zhou, Min Liu and Dengwen Li

    Citation: Cell & Bioscience 2014 4:61

    Content type: Research

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  29. The adapter proteins Appl1 (adaptor protein containing pleckstrin homology domain, phosphotyrosine domain, and leucine zipper motif 1) and Appl2 are highly homologous and involved in several signaling pathways...

    Authors: Liufeng Mao, Wanhua Lin, Tao Nie, Xiaoyan Hui, Xuefei Gao, Kuai Li, Mengxiao Ding, Xiaofeng Tang, Peng Li, Yu Wang, Aimin Xu, Pentao Liu and Donghai Wu

    Citation: Cell & Bioscience 2014 4:60

    Content type: Research

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  30. Akt regulates critical cellular processes including cell survival and proliferation, glucose metabolism, cell migration, cancer progression and metastasis through phosphorylation of a variety of downstream tar...

    Authors: Chia-Hsin Chan, Ukhyun Jo, Abraham Kohrman, Abdol Hossein Rezaeian, Ping-Chieh Chou, Christopher Logothetis and Hui-Kuan Lin

    Citation: Cell & Bioscience 2014 4:59

    Content type: Review

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  31. Glucose and oxygen deprivation during ischemia is known to affect the homeostasis of the endoplasmic reticulum (ER) in ways predicted to activate the unfolded protein response (UPR). Activation of UPR signalli...

    Authors: Danielle E Read, Ananya Gupta, Yury Ladilov, Afshin Samali and Sanjeev Gupta

    Citation: Cell & Bioscience 2014 4:56

    Content type: Research

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  32. Herpes simplex virus (HSV) type 1 has a 152 kb double-stranded DNA genome that may encode more than 80 gene products, many of which remain uncharacterized. The HSV-1 triplex is a complex of three protein subun...

    Authors: You Li, Dongwei Mao, Guoda Ma, Lili Cui, Hua Tao, Haihong Zhou, Wandong Liang, Bin Zhao and Keshen Li

    Citation: Cell & Bioscience 2014 4:55

    Content type: Short report

    Published on:

  33. Both transcriptional factor Ets-1 and integrin αvβ6 play an important role in the development and progression of cancer. The aim of our study was to investigate the expression of Integrin αvβ6 and Ets-1, two p...

    Authors: Cheng Peng, Huijie Gao, Zhengchuan Niu, Ben Wang, Zhen Tan, Weibo Niu, Enyu Liu, Jiayong Wang, Jiuzheng Sun, Muhammad Shahbaz, Michael Agrez and Jun Niu

    Citation: Cell & Bioscience 2014 4:53

    Content type: Research

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  34. Dihydroneopterin aldolase (DHNA) catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin and also the epimerization of DHNP to 7,8-dihydromonapterin. Previously, we determined the...

    Authors: Jaroslaw Blaszczyk, Zhenwei Lu, Yue Li, Honggao Yan and Xinhua Ji

    Citation: Cell & Bioscience 2014 4:52

    Content type: Research

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  35. Ductular reactions (DRs) are well documented in many acute and chronic liver disease. The DRs are thought to be the transit amplifying cells deriving from activation of the stem/progenitor cell compartments of...

    Authors: Fei Ye, Ying-Ying Jing, Shi-Wei Guo, Guo-Feng Yu, Qing-Min Fan, Fang-Fang Qu, Lu Gao, Yang Yang, Dong Wu, Yan Meng, Feng-Hai Yu and Li-Xin Wei

    Citation: Cell & Bioscience 2014 4:50

    Content type: Research

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  36. Peptidylarginine deiminase IV (PADI4) is widely distributed in several tissues and the expression is correlated with many pathological processes. Chemotherapy remains a major treatment alternatively to surgery...

    Authors: Tingting Fan, Changsong Zhang, Ming Zong, Qiudong Zhao, Xue Yang, Chong Hao, Hui Zhang, Shanshan Yu, Jinhu Guo, Ruhan Gong, Shasha Fan, Lixin Wei and Lieying Fan

    Citation: Cell & Bioscience 2014 4:49

    Content type: Research

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  37. Sirtuin1 (SIRT1) is an NAD+-dependent type III histone deacetylase (HDAC). This research investigated the prevalence of SIRT1 protein expression and its prognostic influence with the aim of validating its potenti...

    Authors: Guan-qing Chen, Hui Tian, Wei-ming Yue, Lin Li, Shu-hai Li, Lei Qi, Cun Gao, Li-bo Si, Ming Lu and Fei Feng

    Citation: Cell & Bioscience 2014 4:48

    Content type: Research

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  38. Cholestasis is characterized by an abnormal accumulation of bile acids and causes hepatocellular injury. Recent studies show that autophagy is involved in the pathophysiology of many liver diseases. The potent...

    Authors: Lu Gao, Gang Lv, Xianling Guo, Yingying Jing, Zhipeng Han, Shanshan Zhang, Kai Sun, Rong Li, Yang Yang and Lixin Wei

    Citation: Cell & Bioscience 2014 4:47

    Content type: Research

    Published on: