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  1. Content type: Research

    The excessive accumulation of extracellular matrix of hepatic fibrosis is positively correlated with tissue inhibitors of metalloproteinase 1 (TIMP1). Here we aimed to investigate whether TIMP1 may be down-reg...

    Authors: Dong Jia, Yi-Ran Ni, Yan-Qiong Zhang, Chun Rao, Jun Hou, He-Qing Tang, Chang-Bai Liu and Jiang-Feng Wu

    Citation: Cell & Bioscience 2016 6:31

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  2. Content type: Research

    Lymphopenia promotes naïve T-cell homeostatic proliferation and adoptive effector T-cell survival and memory formation. IL-7 plays a critical role in homeostatic proliferation, survival and memory formation of...

    Authors: Aizhang Xu, Kalpana Kalyanasundaram Bhanumathy, Jie Wu, Zhenmin Ye, Andrew Freywald, Scot C. Leary, Rongxiu Li and Jim Xiang

    Citation: Cell & Bioscience 2016 6:30

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  3. Content type: Letter to the Editor

    Maturity-onset diabetes of the young (MODY), one of the specific types of diabetes mellitus, is a monogenetic disorder characterized by an autosomal dominant (AD) inheritance and β-cell dysfunction. To study a...

    Authors: Jing Yang, Feng Jiang, Hui Guo, Thadimacca Soniya, Chun-xia Yan, Zhu-fang Tian and Bing-yin Shi

    Citation: Cell & Bioscience 2016 6:29

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  4. Content type: Research

    Hydrogen sulfide (H2S), a third member of gasotransmitter family along with nitric oxide and carbon monoxide, generated from mainly catalyzed by cystathionine-lyase, possesses important functions in the cardiovas...

    Authors: Lina Li, Meixiu Li, Youyou Li, Weiming Sun, Yuehong Wang, Shuzhi Bai, Hongxia Li, Bo Wu, Guangdong Yang, Rui Wang, Lingyun Wu, Hongzhu Li and Changing Xu

    Citation: Cell & Bioscience 2016 6:26

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  5. Content type: Review

    The mitochondria are double membrane-bound organelles found in most eukaryotic cells. They generate most of the cell’s energy supply of adenosine triphosphate (ATP). Protein phosphorylation and dephosphorylati...

    Authors: Sangbin Lim, Kelly R. Smith, Ssang-Taek Steve Lim, Rong Tian, Jianrong Lu and Ming Tan

    Citation: Cell & Bioscience 2016 6:25

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  6. Content type: Research

    Non-small cell lung cancer (NSCLC) is the most commonly diagnosed and fatal cancer worldwide. Sclerostin domain containing protein 1 (SOSTDC1) has been found to be tumor-suppressive in several types of cancers...

    Authors: Lei Liu, Shanshan Wu, Yi Yang, Junchao Cai, Xun Zhu, Jueheng Wu, Mengfeng Li and Hongyu Guan

    Citation: Cell & Bioscience 2016 6:24

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  7. Content type: Research

    The prognosis of acute megakaryoblastic leukemia (AMKL) is really dismal, which urges for development of novel treatment. Baicalein is one type of flavonoids extracted from Scutellaria baicalensis Georgi (Huang Q...

    Authors: Chunjie Yu, Jiancheng Zeng, Zhenzhen Yan, Zi Ma, Shangqin Liu and Zan Huang

    Citation: Cell & Bioscience 2016 6:20

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  8. Content type: Research

    The RNA guided CRISPR/Cas9 nucleases have been proven to be effective for gene disruption in various animal models including Xenopus tropicalis. The neural crest (NC) is a transient cell population during embryon...

    Authors: Zhongzhen Liu, Tina Tsz Kwan Cheng, Zhaoying Shi, Ziran Liu, Yong Lei, Chengdong Wang, Weili Shi, Xiongfeng Chen, Xufeng Qi, Dongqing Cai, Bo Feng, Yi Deng, Yonglong Chen and Hui Zhao

    Citation: Cell & Bioscience 2016 6:22

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  9. Content type: Research

    Varicella-zoster virus (VZV) is the causative agent of varicella and zoster. The immediate-early protein, IE62 is the predominant VZ virion tegument protein, transactivating the expression of all kinetic class...

    Authors: Chia-Chi Ku, Yi-Hsuan Chang, Yun Chien and Tsung-Lin Lee

    Citation: Cell & Bioscience 2016 6:21

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  10. Content type: Research

    Exposure of the American bullfrog Lithobates catesbeianus tadpoles to low temperature affects many biological processes including lipid metabolism and the thyroid hormone (TH) signaling pathway, resulting in arre...

    Authors: Shunsuke Suzuki, Koichiro Awai, Akinori Ishihara and Kiyoshi Yamauchi

    Citation: Cell & Bioscience 2016 6:19

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  11. Content type: Research

    Nasopharyngeal carcinoma (NPC) is one of the most common human head and neck cancers with high incidence in Southern China, Southeast Asia and North Africa. Because of its nonspecific symptoms, the early diagn...

    Authors: Yuanwei Guo, Weihao Luo, Zheng Hu, Jia Li, Xiaojie Li, Huiqiu Cao, Jun Li, Bo Wen, Jian Zhang, Hao Cheng, Wangyuan Guo, Tan Tan and Dixian Luo

    Citation: Cell & Bioscience 2016 6:18

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  12. Content type: Research

    Human Papillomavirus is responsible for over 99 % of cervical cancers and is associated with cancers of the head and neck. The currently available prophylactic vaccines against HPV do not generate therapeutic ...

    Authors: Ming-Chieh Yang, Andrew Yang, Jin Qiu, Benjamin Yang, Liangmei He, Ya-Chea Tsai, Jessica Jeang, T.-C. Wu and Chien-Fu Hung

    Citation: Cell & Bioscience 2016 6:17

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  13. Content type: Research

    Human papillomavirus (HPV) has been identified as the primary etiologic factor of cervical cancer as well as subsets of anogenital and oropharyngeal cancers. The two HPV viral oncoproteins, E6 and E7, are uniq...

    Authors: Shiwen Peng, Jin Qiu, Andrew Yang, Benjamin Yang, Jessica Jeang, Joshua W. Wang, Yung-Nien Chang, Cory Brayton, Richard B. S. Roden, Chien-Fu Hung and T.-C. Wu

    Citation: Cell & Bioscience 2016 6:16

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  14. Content type: Review

    Transcriptional activation is a complex, multistage process implemented by hundreds of proteins. Many transcriptional proteins are organized into coactivator complexes, which participate in transcription regul...

    Authors: Aleksey N. Krasnov, Marina Yu. Mazina, Julia V. Nikolenko and Nadezhda E. Vorobyeva

    Citation: Cell & Bioscience 2016 6:15

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  15. Content type: Research

    Glycans play essential roles in biological functions such as differentiation and cancer. Recently, glycans have been considered as biomarkers for physiological aging. However, details regarding the specific gl...

    Authors: Yoko Itakura, Norihiko Sasaki, Daisuke Kami, Satoshi Gojo, Akihiro Umezawa and Masashi Toyoda

    Citation: Cell & Bioscience 2016 6:14

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  16. Content type: Research

    Leishmania contains a concatenated mitochondrial DNA, kDNA. Universal minicircle sequence binding protein (UMSBP), a mitochondrial protein, initiates kDNA replication by binding with ...

    Authors: Ruby Singh, Bidyut Purkait, Kumar Abhishek, Savita Saini, Sushmita Das, Sudha Verma, Abhishek Mandal, Ayan Kr. Ghosh, Yousuf Ansari, Ashish Kumar, Abul H. Sardar, Ajay Kumar, Pradeep Parrack and Pradeep Das

    Citation: Cell & Bioscience 2016 6:13

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  17. Content type: Review

    The proline rich homeodomain protein (PRH), also known as haematopoietically expressed homeobox (HHEX), is an essential transcription factor in embryonic development and in the adult. The PRH protein forms oli...

    Authors: Kevin Gaston, Maria-Angela Tsitsilianos, Kerry Wadey and Padma-Sheela Jayaraman

    Citation: Cell & Bioscience 2016 6:12

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  18. Content type: Research

    Progenitor cells display interesting features for tissue repair and reconstruction. In the last years, such cells have been identified in different cartilage types. In this study, we isolated a migrative subpo...

    Authors: A. F. Elsaesser, S. Schwarz, H. Joos, L. Koerber, R. E. Brenner and N. Rotter

    Citation: Cell & Bioscience 2016 6:11

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  19. Content type: Research

    The runt-related transcription factor 2 (Runx2) is a cell-fate-determining factor that controls osteoblast differentiation and bone formation. It has been previously demonstrated that microRNAs (miRNAs) play i...

    Authors: Shouhe Yu, Qianqian Geng, Qiuhui Pan, Zhongyu Liu, Shan Ding, Qi Xiang, Fenyong Sun, Can Wang, Yadong Huang and An Hong

    Citation: Cell & Bioscience 2016 6:10

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  20. Content type: Research

    The ability of Zn(II) and Cu(II) metal complexes of non-steroidal anti-inflammatory drugs (NSAIDs) to inhibit acute arterial inflammation in vivo has been studied.

    Authors: Rajesh Puranik, Shisan Bao, Antonio M. Bonin, Ravinder Kaur, Jane E. Weder, Llewellyn Casbolt, Trevor W. Hambley, Peter A. Lay, Philip J. Barter and Kerry-Anne Rye

    Citation: Cell & Bioscience 2016 6:9

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  21. Content type: Research

    Inflammatory cytokine is important in modulating injured diseases. Tumor necrosis factor-α (TNF-α), one of potent inflammatory cytokines, plays a dominant role in host defense reaction. However, the concrete e...

    Authors: Yulong Dong, Yuzhou Liu, Xingrui Kou, Yingying Jing, Kai Sun, Dandan Sheng, Guofeng Yu, Dandan Yu, Qiudong Zhao, Xue Zhao, Rong Li, Mengchao Wu and Lixin Wei

    Citation: Cell & Bioscience 2016 6:8

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  22. Content type: Research

    Acute myeloid leukemia (AML) cells can be induced to undergo terminal differentiation with subsequent loss of tumorigenicity using 1,25-dihydroxyvitamin D3 (1,25D) alone or in combination with hematopoietic cytok...

    Authors: Aleksandra Marchwicka, Aoife Corcoran, Klaudia Berkowska and Ewa Marcinkowska

    Citation: Cell & Bioscience 2016 6:7

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  23. Content type: Review

    Breast cancer is the most common cancer among American women, except for skin cancers. About 12 % women in the United States will develop invasive breast cancer during their lifetime. Currently one of the most...

    Authors: Sidney W. Fu, Woojin Lee, Caitrin Coffey, Alexa Lean, Xiaoling Wu, Xiaohui Tan, Yan-gao Man and Rachel F. Brem

    Citation: Cell & Bioscience 2016 6:6

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  24. Content type: Research

    Human head and neck squamous carcinoma is the 6th most prevalent carcinoma worldwide. Although many novel therapies have been developed, the clinical treatment for patients remains non-ideal. Chloride intracel...

    Authors: Haowei Xue, Jinsen Lu, Renxiang Yuan, Jinli Liu, Yehai Liu, Kaile Wu, Jing Wu, Juan Du and Bing Shen

    Citation: Cell & Bioscience 2016 6:5

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  25. Content type: Research

    Translocated in LipoSarcoma (TLS, also known as FUsed in Sarcoma) is an RNA/DNA binding protein whose mutation cause amyotrophic lateral sclerosis. In previous study, we demonstrated that TLS binds to long non...

    Authors: Ryoma Yoneda, Shiho Suzuki, Tsukasa Mashima, Keiko Kondo, Takashi Nagata, Masato Katahira and Riki Kurokawa

    Citation: Cell & Bioscience 2016 6:4

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  26. Content type: Research

    Herpes simplex virus 1 (HSV-1) ICP22 is a multifunctional protein and important for HSV-1 replication. Pseudorabies virus (PRV) ICP22 (P-ICP22) is a homologue of HSV-1 ICP22 and is reported to be able to selec...

    Authors: Mingsheng Cai, Si Jiang, Zhancheng Zeng, Xiaowei Li, Chuncong Mo, Yanjia Yang, Chunke Chen, Peiping Xie, Yun Bian, Jinlin Wang, Jinlu Huang, Daixiong Chen, Tao Peng and Meili Li

    Citation: Cell & Bioscience 2016 6:3

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  27. Content type: Research

    Amphibians are able to survive for several months without food. However, it is unclear what molecular mechanisms underlie their survival. To characterize the intestinal responses to fasting and refeeding, we i...

    Authors: Keiji Tamaoki, Reiko Okada, Akinori Ishihara, Nobuyoshi Shiojiri, Kazuki Mochizuki, Toshinao Goda and Kiyoshi Yamauchi

    Citation: Cell & Bioscience 2016 6:2

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  28. Content type: Methodology

    Virus entry involves multiple steps and is a highly orchestrated process on which successful infection collectively depends. Entry processes are commonly analyzed by monitoring internalized virus particles via...

    Authors: Lia R. Walker, Hosni A. M. Hussein and Shaw M. Akula

    Citation: Cell & Bioscience 2016 6:1

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  29. Content type: Research

    The thyroid hormone (T3)-induced formation of adult intestine during amphibian metamorphosis resembles the maturation of the mammalian intestine during postembryonic development, the period around birth when p...

    Authors: Morihiro Okada, Luan Wen, Thomas C. Miller, Dan Su and Yun-Bo Shi

    Citation: Cell & Bioscience 2015 5:74

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  30. Content type: Research

    Systemic lupus erythematosus (SLE) is a prototypic systemic autoimmune disease. Complement component 4 (C4) has be proved to play a role in pathogenesis of SLE. In the present study, we investigated the effect...

    Authors: Hong-Bin Cheng, Rong-Yi Chen, Jing-Ping Wu, Li Chen, Yan-Hua Liang, Hai-Feng Pan, Zi-Feng Pan, Qing-Hua Zhang, Qing Li, Tian-Xi Du, Yong-Mei Lv and Jian-Qiang Shi

    Citation: Cell & Bioscience 2015 5:73

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  31. Content type: Research

    Lung cancer is the leading cause of cancer-related deaths worldwide, and treatments for lung cancer have a high failure rate. Anti-angiogenic therapy is also often ineffective because of refractory disease. En...

    Authors: Yuyi Wang, Ming Jiang, Zhixi Li, Jiantao Wang, Chi Du, Liu Yanyang, Yang Yu, Xia Wang, Nan Zhang, Maoyuan Zhao, Li Wang, Mei Li and Feng Luo

    Citation: Cell & Bioscience 2015 5:72

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  32. Content type: Research

    Excessive apoptosis of airway epithelium is reported to induce airway remodeling and inhibited airway epithelium repair is highly associated with development of asthma and chronic obstructive pulmonary disease...

    Authors: Chun-Hsiang Lin, Yu-Chuan Hong and Shao-Hsuan Kao

    Citation: Cell & Bioscience 2015 5:71

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  33. Content type: Letter to the Editor

    One mechanism of resistance of the melanoma-associated BRAF kinase to its small molecule inhibitor vemurafenib is by point mutations in its intron 8 resulting in exons 4–8 skipping. In this report, we carried ...

    Authors: Masahiko Ajiro and Zhi-Ming Zheng

    Citation: Cell & Bioscience 2015 5:70

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  34. Content type: Research

    Myotubularin-related protein 14 (MTMR14) is a novel phosphoinositide phosphatase with roles in the maintenance of normal muscle performance, autophagy, and aging in mice. Our initial pilot study demonstrated t...

    Authors: Yin Lv, Lu Xue, Congli Cai, Qing-Hua Liu and Jinhua Shen

    Citation: Cell & Bioscience 2015 5:69

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  35. Content type: Methodology

    RNA interference (RNAi) is a robust tool for inhibiting specific gene expression, but it is limited by the uncertain efficiency of siRNA or shRNA constructs. It has been shown that the overexpression of ARGONA...

    Authors: Jiening He, Lian Huang, Huiling Qiu, Jiexuan Li, Lan Luo, Yanjiao Li, Shengli Tian, Kang Kang, Jun Luo, Lin Liu and Deming Gou

    Citation: Cell & Bioscience 2015 5:67

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  36. Content type: Research

    The initiation of hepatitis B virus (HBV) replication involves the formation of covalently closed circular DNA (cccDNA) and its transcription into pregenomic RNA (pgRNA) in hepatocyte nuclei. The regulatory me...

    Authors: Hui Wang, KeHui Liu, Bernard A. M. Fang, HaiQing Wu, FengDi Li, XiaoGang Xiang, WeiLiang Tang, GangDe Zhao, LanYi Lin, Shisan Bao and Qing Xie

    Citation: Cell & Bioscience 2015 5:66

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  37. Content type: Research

    Exposure to a moderate to high dose of ionizing radiation (IR) not only causes acute radiation syndrome but also induces long-term (LT) bone marrow (BM) injury. The latter effect of IR is primarily attributed ...

    Authors: Chengcheng Li, Lu Lu, Junling Zhang, Song Huang, Yonghua Xing, Mingfeng Zhao, Daohong Zhou, Deguan Li and Aimin Meng

    Citation: Cell & Bioscience 2015 5:65

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  38. Content type: Research

    Use of low doses of digitalis to prevent the development of heart failure was advocated decades ago, but conflicting results of early animal studies dissuaded further research on this issue. Recent discoverie...

    Authors: Jian Wu, Daxiang Li, Lingling Du, Mustafa Baldawi, Marjorie E. Gable, Amir Askari and Lijun Liu

    Citation: Cell & Bioscience 2015 5:64

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  39. Content type: Review

    Nuclear factor κB (NF-κB) is a family of inducible transcription factors that plays a vital role in different aspects of immune responses. NF-κB is normally sequestered in the cytoplasm as inactive complexes v...

    Authors: Haisong Zhang and Shao-Cong Sun

    Citation: Cell & Bioscience 2015 5:63

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  40. Content type: Review

    Skeletal muscle fibers are generally classified into two groups: slow (type I) and fast (type II). Fibers in each group are uniquely designed for specific locomotory needs based on their intrinsic cellular pro...

    Authors: Victor M. Luna, Eriko Daikoku and Fumihito Ono

    Citation: Cell & Bioscience 2015 5:62

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  41. Content type: Research

    The directed differentiation of mesenchymal stem cells (MSCs) is tightly controlled by a complex network. Wnt signaling pathways have an important function in controlling the fate of MSCs. However, the mechan...

    Authors: Yuanfei Zhou, Zheng Zhou, Wei Zhang, Xiaoming Hu, Hongkui Wei, Jian Peng and Siwen Jiang

    Citation: Cell & Bioscience 2015 5:61

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  42. Content type: Review

    Hepatocyte nuclear factor-1beta (HNF1β) was initially identified as a liver-specific transcription factor. It is a homeobox transcription factor that functions as a homodimer or heterodimer with HNF1α. HNF1β p...

    Authors: Dan-Dan Yu, Shi-Wei Guo, Ying-Ying Jing, Yu-Long Dong and Li-Xin Wei

    Citation: Cell & Bioscience 2015 5:58

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  43. Content type: Letter to the Editor

    Some inherited coagulation factor deficiencies are caused by intracellular retention or degradation of misfolded proteins, and chemical chaperones have been shown to reverse protein misfolding. The purpose of ...

    Authors: Maria Eugenia Chollet, Ellen Skarpen, Nina Iversen, Per Morten Sandset and Grethe Skretting

    Citation: Cell & Bioscience 2015 5:57

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  44. Content type: Research

    MicroRNA-720 (miR-720), a nonclassical miRNA, is involved in the initiation and progression of several tumors. In our previous studies, miR-720 was shown to be significantly upregulated in cervical cancer tiss...

    Authors: Yunlan Tang, Yi Lin, Chuang Li, Xunwu Hu, Yi Liu, Mingyang He, Jun Luo, Guihong Sun, Tao Wang, Wenxin Li and Mingxiong Guo

    Citation: Cell & Bioscience 2015 5:56

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