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  1. Cancer/testis (CT) antigens/genes are usually overexpressed in cancers and exhibit high immunogenicity, making them promising targets for immunotherapy and cancer vaccines. The role of serine protease PRSS56 i...

    Authors: Dandan Li, Lingyun Xia, Pan Huang, Zidi Wang, Qiwei Guo, Congcong Huang, Weidong Leng and Shanshan Qin
    Citation: Cell & Bioscience 2023 13:124
  2. Maintaining homeostasis of Ca2+ stores in the endoplasmic reticulum (ER) is crucial for proper Ca2+ signaling and key cellular functions. Although Ca2+ depletion has been known to cause ER stress which in turn ac...

    Authors: Song Zhao, Haiping Feng, Dongfang Jiang, Keyan Yang, Si-Tong Wang, Yu-Xin Zhang, Yun Wang, Hongmei Liu, Caixia Guo and Tie-Shan Tang
    Citation: Cell & Bioscience 2023 13:123
  3. Salivary carcinoma ex pleomorphic adenoma (CXPA) is defined as a carcinoma that develops from benign pleomorphic adenoma (PA). Abnormally activated Androgen signaling pathway and amplification of HER-2/neu(ERBB-2...

    Authors: Wanling Chen, Ting Gu, Qianqian Chen, Chuxiang Qu, Chunye Zhang, Yuhua Hu, Ronghui Xia, Ying Zhang, Min Wang, Xinyi Huang, Jiang Li, Chaoji Shi and Zhen Tian
    Citation: Cell & Bioscience 2023 13:122
  4. BRAFV600E comes as two main splicing variants. The well-studied ref isoform and the recently discovered X1 isoform are co-expressed in cancer cells and differ in terms of 3’UTR length and sequence, as well as ...

    Authors: Raffaella De Paolo, Samanta Sarti, Sara Bernardi, Francesco Cucco, Andrea Tavosanis, Letizia Pitto and Laura Poliseno
    Citation: Cell & Bioscience 2023 13:121
  5. Immune checkpoint inhibitors (ICIs) targeting CTLA-4 and PD-1/PD-L1 to boost tumor-specific T lymphocyte immunity have opened up new avenues for the treatment of various histological types of malignancies, wit...

    Authors: Bin Wang, Yin Han, Yuyu Zhang, Qin Zhao, Huanhuan Wang, Jinlong Wei, Lingbin Meng, Ying Xin and Xin Jiang
    Citation: Cell & Bioscience 2023 13:120
  6. Cones are essential for color recognition, high resolution, and central vision; therefore cone death causes blindness. Understanding the pathophysiology of each cell type in the retina is key to developing the...

    Authors: Nan-Kai Wang, Pei-Kang Liu, Yang Kong, Yun-Ju Tseng, Laura A. Jenny, Nicholas D. Nolan, Nelson Chen, Hung-Hsi Wang, Chun Wei Hsu, Wan-Chun Huang, Janet R. Sparrow, Chyuan-Sheng Lin and Stephen H. Tsang
    Citation: Cell & Bioscience 2023 13:119
  7. Artemisia argyi (A. argyi), also called Chinese mugwort, has been widely used to control pandemic diseases for thousands of years since ancient China due to its anti-microbial infection, anti-allergy, and anti-in...

    Authors: Fang-Ju Cheng, Chien-Yi Ho, Tzong-Shiun Li, Yeh Chen, Yi-Lun Yeh, Ya-Ling Wei, Thanh Kieu Huynh, Bo-Rong Chen, Hung-Yu Ko, Chen-Si Hsueh, Ming Tan, Yang-Chang Wu, Hui-Chi Huang, Chih-Hsin Tang, Chia-Hung Chen, Chih-Yen Tu…
    Citation: Cell & Bioscience 2023 13:118
  8. Hepatic liver disease, including primary sclerosing cholangitis (PSC), is a serious extraintestinal manifestations of colonic inflammation. Cyclic adenosine monophosphate (cAMP)-responsive element-binding prot...

    Authors: Sang-Hee Lee, Sung-Je Moon, Seung Hee Woo, Gwangsook Ahn, Won Kon Kim, Chul-Ho Lee and Jung Hwan Hwang
    Citation: Cell & Bioscience 2023 13:116
  9. Hematopoietic stem cells (HSCs) reside in the bone marrow (BM) niche, which includes bone-forming and bone-resorbing cells, i.e., osteoblasts (OBs) and osteoclasts (OCs). OBs originate from mesenchymal progeni...

    Authors: Alessia Oppezzo, Lovely Monney, Henri Kilian, Lofti Slimani, Frédérique Maczkowiak-Chartois and Filippo Rosselli
    Citation: Cell & Bioscience 2023 13:115
  10. Transcription factor FOXM1 is a potential target for anti-cancer drug development. An interfering peptide M1-21, targeting FOXM1 and FOXM1-interacting proteins, is developed and its anti-cancer efficacy is eva...

    Authors: Haojie Cheng, Jie Yuan, Chaozhu Pei, Min Ouyang, Huitong Bu, Yan Chen, Xiaoqin Huang, Zhenwang Zhang, Li Yu and Yongjun Tan
    Citation: Cell & Bioscience 2023 13:114
  11. Acne is a chronic inflammatory skin disorder that profoundly impacts the quality of life of patients worldwide. While it is predominantly observed in adolescents, it can affect individuals across all age group...

    Authors: Cong Huang, Fan Zhuo, Baoquan Han, Wenting Li, Bin Jiang, Kaoyuan Zhang, Xingling Jian, Zhenzhen Chen, Hui Li, Haiyan Huang, Xia Dou and Bo Yu
    Citation: Cell & Bioscience 2023 13:113
  12. Pulmonary vein stenosis (PVS), one of the most challenging clinical problems in congenital heart disease, leads to secondary pulmonary arterial hypertension (PAH) and right ventricular (RV) hypertrophy. Due to...

    Authors: Debao Li, Lisheng Qiu, Haifa Hong, Hao Chen, Peibin Zhao, Yingying Xiao, Hao Zhang, Qi Sun and Lincai Ye
    Citation: Cell & Bioscience 2023 13:112
  13. The early accurate diagnoses for autoimmune encephalitis (AE) and infectious encephalitis (IE) are essential since the treatments for them are different. This study aims to discover some specific and sensitive...

    Authors: Siyuan Fan, Xiangyan He, Zhongyi Zhu, Lu Chen, Yijun Zou, Zhonglin Chen, Jialin Yu, Weijun Chen, Hongzhi Guan and Jinmin Ma
    Citation: Cell & Bioscience 2023 13:111
  14. Angiotensin II type 1 receptor (AT1R) is a promising therapeutic target for cardiovascular diseases. Compared with orthosteric ligands, allosteric modulators attract considerable attention for drug development...

    Authors: Xi Zhang, Suli Zhang, Meili Wang, Hao Chen and Huirong Liu
    Citation: Cell & Bioscience 2023 13:110
  15. Gene editing has emerged as an exciting therapeutic development platform for numerous genetic and nongenetic diseases. Targeting lipid-modulating genes such as angiopoietin-related protein 3 (ANGPTL3) with gene e...

    Authors: Yuanbojiao Zuo, Chen Zhang, Yuan Zhou, Haiwen Li, Weidong Xiao, Roland W. Herzog, Jie Xu, Jifeng Zhang, Y. Eugene Chen and Renzhi Han
    Citation: Cell & Bioscience 2023 13:109
  16. Various renal abnormalities, including hydronephrosis, polycystic kidney disease, and hydroureter, have been reported, and these abnormalities are present in DiGeorge syndrome, renal dysplasia, and acute kidne...

    Authors: Jong-Min Lee, Tae-Yang Lim, Sang-Bin Oh, Seung-Jun Lee, Yun Soo Bae and Han-Sung Jung
    Citation: Cell & Bioscience 2023 13:108
  17. Cisplatin is commonly used to treat cervical cancer while drug resistance limits its effectiveness. There is an urgent need to identify strategies that increase cisplatin sensitivity and improve the outcomes o...

    Authors: Xin Wang, Chen Cao, Xiangyu Tan, Xueyao Liao, Xiaofang Du, Xueqian Wang, Ting Liu, Danni Gong, Zheng Hu and Xun Tian
    Citation: Cell & Bioscience 2023 13:107
  18. Bile acids (BA) are important physiological molecules not only mediating nutrients absorption and metabolism in peripheral tissues, but exerting neuromodulation effect in the central nerve system (CNS). The ca...

    Authors: Chen Xing, Xin Huang, Dongxue Wang, Dengjun Yu, Shaojun Hou, Haoran Cui and Lung Song
    Citation: Cell & Bioscience 2023 13:106

    The Correction to this article has been published in Cell & Bioscience 2023 13:125

  19. Mesenchymal progenitors (MPs) are considered to play vital roles in bone development, growth, bone turnover, and repair. In recent years, benefiting from advanced approaches such as single-cell sequence, linea...

    Authors: Fangyuan Shen, Xiaobin Huang, Guangxu He and Yu Shi
    Citation: Cell & Bioscience 2023 13:105
  20. Neoadjuvant chemotherapy (NACT) becomes the first-line option for advanced tumors, while patients who are not sensitive to it may not benefit. Therefore, it is important to screen patients suitable for NACT.

    Authors: Qihai Sui, Zhengyang Hu, Xing Jin, Yunyi Bian, Jiaqi Liang, Huan Zhang, Huiqiang Yang, Zongwu Lin, Qun Wang, Cheng Zhan and Zhencong Chen
    Citation: Cell & Bioscience 2023 13:103

    The Correction to this article has been published in Cell & Bioscience 2023 13:133

  21. Free fatty acid receptors (FFARs) and toll-like receptors (TLRs) recognize microbial metabolites and conserved microbial products, respectively, and are functionally implicated in inflammation and cancer. Howe...

    Authors: Mi-Jeong Kim, Ji Young Kim, Ji Hye Shin, Yeeun Kang, Ji Su Lee, Juhee Son, Soo-Kyung Jeong, Daesik Kim, Duk-Hwan Kim, Eunyoung Chun and Ki-Young Lee
    Citation: Cell & Bioscience 2023 13:102
  22. Olfactory dysfunction is among the earliest non-motor symptoms of Parkinson’s disease (PD). As the foremost pathological hallmark, α-synuclein initiates the pathology in the olfactory pathway at the early stag...

    Authors: Xing-Yang Liu, Ke Wang, Xian-Hua Deng, Yi-Hua Wei, Rui Guo, Sui-Feng Liu, Yi-Fan Zhu, Jia-Jun Zhong, Jing-Yuan Zheng, Meng-Dan Wang, Qiu-Hong Ye, Jian-Quan He, Kai-Hang Guo, Jun-Rong Zhu, Shu-Qiong Huang, Ze-Xu Chen…
    Citation: Cell & Bioscience 2023 13:101
  23. PRPP synthase (PRPS) transfers the pyrophosphate groups from ATP to ribose-5-phosphate to produce 5-phosphate ribose-1-pyrophosphate (PRPP), a key intermediate in the biosynthesis of several metabolites includ...

    Authors: Guang-Ming Lu, Huan-Huan Hu, Chia-Chun Chang, Jiale Zhong, Xian Zhou, Chen-Jun Guo, Tianyi Zhang, Yi-Lan Li, Boqi Yin and Ji-Long Liu
    Citation: Cell & Bioscience 2023 13:100
  24. Excessive and unresolved neuroinflammation plays an important role in the pathophysiology of many neurological disorders, such as ischemic stroke, yet there are no effective treatments. Tripartite motif-contai...

    Authors: Yongbo Yu, Qian Xia, Gaofeng Zhan, Shuai Gao, Tangrui Han, Meng Mao, Xing Li and Yonghong Wang
    Citation: Cell & Bioscience 2023 13:99
  25. For comprehensive studies of the brain structure and function, fluorescence imaging of the whole brain is essential. It requires large-scale volumetric imaging in cellular or molecular resolution, which could ...

    Authors: Kang Wang, Yuxin Yu, Yinhui Xu, Yingzi Yue, Fang Zhao, Wenyang Feng, Yijie Duan, Weicheng Duan, Jingjing Yue, Zhiyun Liao, Peng Fei, Hui Sun and Bo Xiong
    Citation: Cell & Bioscience 2023 13:97
  26. Patients suffered from severe traumatic brain injury (TBI) have twice the risk of developing into neurodegenerative diseases later in their life. Thus, early intervention is needed not only to treat TBI but al...

    Authors: Min-Zong Liang, Ting-Hsuan Lu and Linyi Chen
    Citation: Cell & Bioscience 2023 13:96
  27. Tau protein forms neurofibrillary tangles and becomes deposited in the brain during Alzheimer’s disease (AD). Tau oligomers are the most reactive species, mediating neurotoxic and inflammatory activity. Microg...

    Authors: Subashchandrabose Chinnathambi and Rashmi Das
    Citation: Cell & Bioscience 2023 13:95
  28. Spermatogenic dysfunction is an important cause of azoospermia. Numerous studies have focused on germ-cell-related genes that lead to spermatogenic impairment. However, based on the immune-privileged character...

    Authors: Fan Dong, Ping Ping, Si-Qi Wang, Yi Ma and Xiang-Feng Chen
    Citation: Cell & Bioscience 2023 13:94
  29. Urolithiasis with high prevalence and recurrence rate, has impacts on kidney injury in patients, becomes a socioeconomic and healthcare problem in worldwide. However, the biology of kidney with crystal formati...

    Authors: Zhu Wang, Qiong Deng, Yanli Gu, Min Li, Yeda Chen, Jieyan Wang, Ying Zhang, Jianwen Zhang, Qiyi Hu, Shenping Zhang, Wei Chen, Zhenhua Chen, Jiaying Li, Xisheng Wang and Hui Liang
    Citation: Cell & Bioscience 2023 13:92
  30. Cysteinyl cathepsins (CTSs) are widely known to have a proteolysis function that mediates recycling of unwanted proteins in endosomes and lysosomes, and investigation of CTSs has greatly improved with advances...

    Authors: Xian Wu Cheng, Megumi Narisawa, Hailong Wang and Limei Piao
    Citation: Cell & Bioscience 2023 13:91
  31. Chronic stress exposure increases the risk of mental health problems such as anxiety and depression. The medial prefrontal cortex (mPFC) is a hub for controlling stress responses through communicating with mul...

    Authors: Wei-Zhu Liu, Chun-Yan Wang, Yu Wang, Mei-Ting Cai, Wei-Xiang Zhong, Tian Liu, Zhi-Hao Wang, Han-Qing Pan, Wen-Hua Zhang and Bing-Xing Pan
    Citation: Cell & Bioscience 2023 13:90
  32. Tumor hypoxia stimulates release of extracellular vesicles (EVs) that facilitate short- and long-range intercellular communication and metastatization. Albeit hypoxia and EVs release are known features of Neur...

    Authors: Pina Fusco, Anna Fietta, Maria Rosaria Esposito, Luca Zanella, Sara Micheli, Angelica Bastianello, Lorenzo Bova, Giulia Borile, Giuseppe Germano and Elisa Cimetta
    Citation: Cell & Bioscience 2023 13:89
  33. Extended pluripotent stem cells (EPSCs) can contribute to both embryonic and trophectoderm-derived extraembryonic tissues. Therefore, EPSCs have great application significance for both research and industry. H...

    Authors: Chunfang Hao, Shilong Chu, Xiongzhi Quan, Tiancheng Zhou, Junjie Shi, Xiaofen Huang, Guangming Wu, Micky Daniel Tortorella and Duanqing Pei
    Citation: Cell & Bioscience 2023 13:88
  34. Ferroptosis is a unique cell death, dependent on iron and phospholipid peroxidation, involved in massive processes of physiopathology. Tremendous attention has been caught in oncology, particularly for those t...

    Authors: Hongting Zhao, Meng Zhang, Jinghua Zhang, Zichen Sun, Wenxin Zhang, Weichen Dong, Chen Cheng, Yongzhong Yao and Kuanyu Li
    Citation: Cell & Bioscience 2023 13:87
  35. Stress granules (SGs) are non-enveloped structures formed primarily via protein and RNA aggregation under various stress conditions, including hypoxia and viral infection, as well as oxidative, osmotic, and he...

    Authors: Huan Zhou, Jing Luo, Kelin Mou, Lin Peng, Xiaoyue Li, Yulin Lei, Jianmei Wang, Sheng Lin, Yuhao Luo and Li Xiang
    Citation: Cell & Bioscience 2023 13:86
  36. ISGylation is a post-translational protein modification that regulates many life activities, including immunomodulation, antiviral responses, and embryo implantation. The exact contribution of ISGylation to fo...

    Authors: Yaru Chen, Jiawei Zhou, Shang Wu, Lei Wang, Gaogui Chen, Dake Chen, Xianwen Peng, Yi-Liang Miao, Shuqi Mei and Fenge Li
    Citation: Cell & Bioscience 2023 13:84
  37. Targeted genome editing is a powerful tool for studying gene function in almost every aspect of biological and pathological processes. The most widely used genome editing approach is to introduce engineered en...

    Authors: Liezhen Fu, Emily Ma, Morihiro Okada, Yuki Shibata and Yun-Bo Shi
    Citation: Cell & Bioscience 2023 13:83
  38. Meiotic recombination is initiated by Spo11-dependent programmed DNA double-strand breaks (DSBs) that are preferentially concentrated within genomic regions called hotspots; however, the factor(s) that specify...

    Authors: Chao Liu, Wei Xu, Liying Wang, Zhuo Yang, Kuan Li, Jun Hu, Yinghong Chen, Ruidan Zhang, Sai Xiao, Wenwen Liu, Huafang Wei, Jia-Yu Chen, Qianwen Sun and Wei Li
    Citation: Cell & Bioscience 2023 13:82
  39. Nicotinamide adenine dinucleotide (NAD+) is a critical metabolite that acts as a cofactor in energy metabolism, and serves as a cosubstrate for non-redox NAD+-dependent enzymes, including sirtuins, CD38 and poly(...

    Authors: Jiankai Fang, Wangwang Chen, Pengbo Hou, Zhanhong Liu, Muqiu Zuo, Shisong Liu, Chao Feng, Yuyi Han, Peishan Li, Yufang Shi and Changshun Shao
    Citation: Cell & Bioscience 2023 13:81
  40. Ultraviolet A (UVA) irradiation can lead to skin damage and premature skin aging known as photoaging. This work found that UVA irradiation caused an imbalance between dermal matrix synthesis and degradation th...

    Authors: Yinan Li, Xiu Huang, Jing Jin, Haohao Zhang, Kai Yang, Jingxia Han, Ying Lv, Yu Sun, Cheng Yao, Tingting Lin, Caibin Zhu and Huijuan Liu
    Citation: Cell & Bioscience 2023 13:80
  41. Where the gene is expressed determines the function of the gene. Neuregulin 1 (Nrg1) encodes a tropic factor and is genetically linked with several neuropsychiatry diseases such as schizophrenia, bipolar disor...

    Authors: Chen-Yun Ding, Yan-Ting Ding, Haifeng Ji, Yao-Yi Wang, Xinwen Zhang and Dong-Min Yin
    Citation: Cell & Bioscience 2023 13:79
  42. . Up to 20% of people with HIV (PWH) who undergo virologically suppressed antiretroviral therapy (ART) fail to experience complete immune restoration. We recently reported that plasma anti-CD4 IgG (antiCD4IgG)...

    Authors: Xiaoyu Fu, Da Cheng, Zhenwu Luo, Sonya L. Heath, Ruth Adekunle, John E McKinnon, Lisa Martin, Zizhang Sheng, Enrique Espinosa and Wei Jiang
    Citation: Cell & Bioscience 2023 13:78
  43. Chronic cholestatic liver diseases, such as primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC), are associated with bile stasis and gradually progress to fibrosis, cirrhosis, and liver ...

    Authors: Jing Zeng, Jiangao Fan and Huiping Zhou
    Citation: Cell & Bioscience 2023 13:77
  44. Cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway is critical for cytosolic DNA-sensing and the subsequent immune responses. The inappropriate activation of this pathway leads to DN...

    Authors: Yu Yu, Miao Wang, Xiao-Wei Li, Jie Mao, Ying-Jie Zhu, Na Wang, Le-Hua Yin, Zeng-Lin Guo, Hong Cai, Tao Li, Ting-Ting Liang, Jiuwei Cui and Tao Zhou
    Citation: Cell & Bioscience 2023 13:76