Articles

Dysregulation of the calcium handling protein, CCDC47, is associated with diabetic cardiomyopathy

Diabetes mellitus is associated with an increased risk in diabetic cardiomyopathy (DCM) that is distinctly not attributed to co-morbidities with other vasculature diseases. To date, while dysregulation of calc...

Authors: Khampaseuth Thapa, Kai Connie Wu, Aishwarya Sarma, Eric M. Grund, Angela Szeto, Armando J. Mendez, Stephane Gesta, Vivek K. Vishnudas, Niven R. Narain and Rangaprasad Sarangarajan

The 2017 Ming K. Jeang award for excellence in Cell & Bioscience

Two research groups led by Dr. Shui Qing Ye of University of Missouri Kansas City School of Medicine, Kansas City, USA and Dr. Dihua Yu of University of Texas MD Anderson Cancer Center, Houston, USA, respectiv...

Authors: Yun-Bo Shi

Role of MCM2–7 protein phosphorylation in human cancer cells

A heterohexameric complex composed of minichromosome maintenance protein 2–7 (MCM2–7), which acts as a key replicative enzyme in eukaryotes, is crucial for initiating DNA synthesis only once per cell cycle. Th...

Authors: Liangru Fei and Hongtao Xu

Long non-coding RNA CASC15 promotes melanoma progression by epigenetically regulating PDCD4

Long non-coding RNAs (LncRNAs) have been identified as critical regulators in a variety of cancer types. Cancer susceptibility candidate 15 (CASC15), a lncRNA located at chromosome 6p22.3, has been discovered ...

Authors: Yakun Yin, Bin Zhao, Dongqin Li and Guangwen Yin

Mutant huntingtin induces iron overload via up-regulating IRP1 in Huntington’s disease

Iron accumulation in basal ganglia accompanies neuronal loss in Huntington’s disease (HD) patients and mouse disease models. Disruption of HD brain iron homeostasis occurs before the onset of clinical signs. T...

Authors: Li Niu, Cuifang Ye, Yun Sun, Ting Peng, Shiming Yang, Weixi Wang and He Li

NICD-mediated notch transduction regulates the different fate of chicken primordial germ cells and spermatogonial stem cells

Notch signaling is mainly regulated by Notch1 during development of chicken germ stem cells; however, the molecular mechanisms that contribute to generation of these germ stem cells have not been thoroughly in...

Authors: Qisheng Zuo, Chen Zhang, Kai Jin, Jin Jing, Changhua Sun, Mahmoud F. Ahmed, Jiuzhou Song, Yani Zhang, Guohong Chen and Bichun Li

Calcium signaling: an underlying link between cardiac disease and carcinogenesis

Authors: Xuehong Xu, Steven P. Balk, William B. Isaacs and Jianjie Ma

Heat shock protein 70 protects mouse against post-infection irritable bowel syndrome via up-regulating intestinal γδ T cell’s Th17 response

This study investigated the role of HSP70 in modulating intestinal γδ T cells’ Th17 response in Trichinella spiralis-induced PI-IBS mice model.

Authors: Zhoutao He, Xiaoning Sun, Zhichao Ma, Jiao Fu, Baili Huang, Fujin Liu, Yi Chen, Taozhi Deng, Xiangyang Han, Deming Sun and Cheng Lan

A superior bright NIR luminescent nanoparticle preparation and indicating calcium signaling detection in cells and small animals

Near-field fluorescence (NFF) effects were employed to develop a novel near-infrared (NIR) luminescent nanoparticle (LNP) with superior brightness. The LNP is used as imaging contrast agent for cellular and sm...

Authors: Jian Zhang and Joseph. R. Lakowicz

Aspirin inhibited the metastasis of colon cancer cells by inhibiting the expression of toll-like receptor 4

Authors: Suaka Kagbo-Kue, Taiwo Ajose and Nicolas Bakinde

RINCK-mediated monoubiquitination of cGAS promotes antiviral innate immune responses

As an important danger signal, the presence of DNA in cytoplasm triggers potent immune responses. Cyclic GMP-AMP synthase (cGAS) is a recently characterized key sensor for cytoplasmic DNA. The engagement of cG...

Authors: Zhao-Shan Liu, Zi-Yu Zhang, Hong Cai, Ming Zhao, Jie Mao, Jiang Dai, Tian Xia, Xue-Min Zhang and Tao Li

Tumor cells versus host immune cells: whose PD-L1 contributes to PD-1/PD-L1 blockade mediated cancer immunotherapy?

Antibody blockade of the PD-1/PD-L1 pathway has elicited durable antitumor responses in the therapy of a broad spectrum of cancers. PD-L1 is constitutively expressed in certain tumors and host immune cells, an...

Authors: Fei Tang and Pan Zheng

NOS2 deficiency has no influence on the radiosensitivity of the hematopoietic system

Previous studies have shown that inhibition of inducible NO synthase (NOS2 or iNOS) with an inhibitor can selectively protect several normal tissues against radiation during radiotherapy. However, the role of ...

Authors: Chengcheng Li, Yi Luo, Lijian Shao, Aimin Meng and Daohong Zhou

Cardiac regeneration in Xenopus tropicalis and Xenopus laevis: discrepancies and problems

Two studies have recently focused on adult heart regeneration in Xenopus. While we reported on cardiac myogenic regeneration in Xenopus tropicalis after injury, Marshall and colleagues found no regeneration in an...

Authors: Souqi Liao, Wenyan Dong, Hui Zhao, Ruijin Huang, Xufeng Qi and Dongqing Cai

Is adult cardiac regeneration absent in Xenopus laevis yet present in Xenopus tropicalis?

We recently used an endoscopy-based resection method to explore the consequences of cardiac injury in adult Xenopus laevis, obtaining the result that the adult Xenopus heart is unable to regenerate. At 11 months ...

Authors: Lindsey Marshall, Fabrice Girardot, Barbara A. Demeneix and Laurent Coen

Anti-CTLA-4 antibodies in cancer immunotherapy: selective depletion of intratumoral regulatory T cells or checkpoint blockade?

Antibodies to human CTLA-4 have been shown to induce long-lasting protection against melanoma. It is assumed that these antibodies cause tumor rejection by blocking negative signaling from the B7-CTLA-4 intera...

Authors: Fei Tang, Xuexiang Du, Mingyue Liu, Pan Zheng and Yang Liu

Characterization and potential role of microRNA in the Chinese dominant malaria mosquito Anopheles sinensis (Diptera: Culicidae) throughout four different life stages

microRNAs (miRNAs) are one kind of small non-coding RNAs widely distributed in insects. Many studies have shown that miRNAs play critical roles in development, differentiation, apoptosis, and innate immunity. ...

Authors: Xinyu Feng, Jiatong Wu, Shuisen Zhou, Jingwen Wang and Wei Hu

A novel organ preservation solution with efficient clearance of red blood cells improves kidney transplantation in a canine model

Organ preservation solutions are designed to minimize organ damage during transplantation. A novel preservation solution, WMO-II, was developed to have a low viscosity and to improve microvasculature perfusion...

Authors: Sheng Wang, Kristyn Gumpper, Tao Tan, Xianzhang Luo, Hui Guo, Changsheng Ming, Hanying Jiang, Jiangguo Fang, Guang Du, Hua Zhu, Jianjie Ma, Zhishui Chen and Nianqiao Gong

Ghrelin therapy mitigates bone marrow injury and splenocytopenia by sustaining circulating G-CSF and KC increases after irradiation combined with wound

Radiation injury combined wound (CI) enhances acute radiation syndrome and subsequently mortality as compared to radiation injury alone (RI). We previously reported that ghrelin (a 28-amino-acid-peptide secret...

Authors: Juliann G. Kiang, Marsha N. Anderson and Joan T. Smith

INAVA promotes aggressiveness of papillary thyroid cancer by upregulating MMP9 expression

Innate immunity activator (INAVA) has been shown to be elevated in lung adenocarcinoma. However, its expression pattern and function in papillary thyroid cancer (PTC) are unknown. This study aimed to identify ...

Authors: Hongyu Guan, Yan Guo, Liehua Liu, Runyi Ye, Weiwei Liang, Hai Li, Haipeng Xiao and Yanbing Li

A temporal examination of calcium signaling in cancer- from tumorigenesis, to immune evasion, and metastasis

Although the study of calcium (Ca²⁺) is classically associated with excitable cells such as myocytes or neurons, the ubiquity of this essential element in all cellular processes has led to interest in other cell ...

Authors: MengMeng Xu, Andreas Seas, Musa Kiyani, Keven S. Y. Ji and Hannah N. Bell

Syncytium calcium signaling and macrophage function in the heart

Macrophages are traditionally viewed as a key component of the immunity defense system. Recent studies have identified resident macrophages in multiple organs including the heart, in which the cells perform th...

Authors: Xin Zhou, Zhongguang Li, Zefan Wang, Eda Chen, Juan Wang, Frederic Chen, Odell Jones, Tao Tan, Shawn Chen, Hiroshi Takeshima, Joseph Bryant, Jianjie Ma and Xuehong Xu

TP53TG1 enhances cisplatin sensitivity of non-small cell lung cancer cells through regulating miR-18a/PTEN axis

The acquisition of drug resistance has been considered as a main obstacle for cancer chemotherapy. Tumor protein 53 target gene 1 (TP53TG1), a p53-induced lncRNA, plays a vital role in the progression of human...

Authors: Huijuan Xiao, Yihe Liu, Pan Liang, Bo Wang, Hongna Tan, Yonggao Zhang, Xianzheng Gao and Jianbo Gao

Enhanced calcium ion mobilization in osteoblasts on amino group containing plasma polymer nanolayer

Biomaterial modifications—chemical and topographical—are of particular importance for the integration of materials in biosystems. Cells are known to sense these biomaterial characteristics, but it has remained...

Authors: Susanne Staehlke, Henrike Rebl, Birgit Finke, Petra Mueller, Martina Gruening and J. Barbara Nebe

Transplantation of endothelial progenitor cells attenuated paraquat-induced acute lung injury via miR-141-3p-Notch-Nrf2 axis

Paraquat (PQ) presents with high toxicity for humans and animals, and the lungs become the main target organ by the poisoning of PQ leading to acute lung injury. Endothelial progenitor cells (EPCs) were proved...

Authors: Yan Jin, Wei Liu, Xiaowei Liu, Tao Ma, Chen Yang, Quan Cai and Zhi Liu

The development of salt-sensitive hypertension regulated by PSGL-1 gene in mice

Chronic inflammatory is involved in the development of salt-sensitive hypertension and other cardiovascular diseases. PSGL-1 plays an important role in the inflammatory response.

Authors: Yuhui Yang, Xue Liu, Yunpeng Liu, Hui Fu, Ying Gao, Xing Liu and Xiaoliang Jiang

LncRNA KCNQ1OT1 promotes osteogenic differentiation to relieve osteolysis via Wnt/β-catenin activation

Resveratrol (RSV) has been reported to stimulate osteoblast differentiation in which Wnt/β-catenin signaling pathway played a crucial role. However, whether and how RSV activated Wnt/β-catenin pathway in osteo...

Authors: Xuren Gao, Jian Ge, Weiyi Li, Wangchen Zhou and Lei Xu

Correction to: PML: Regulation and multifaceted function beyond tumor suppression

In the publication of this article [1], there is an error in Table 3. The position of the black arrow and the terms CBP, Cdk1/2 and STAT3 of Table 3 were placed incorrectly in the online version while these we...

Authors: Kuo-Sheng Hsu and Hung-Ying Kao

The suppressing role of miR-622 in renal cell carcinoma progression by down-regulation of CCL18/MAPK signal pathway

MicroRNAs have emerged as critical modulators of carcinogenesis and tumor progression including renal cell carcinoma (RCC). MiR-622 plays as a tumor inhibitor in some types of cancer, however, its role in kidn...

Authors: Tian Li, Xiangzhou Sun and Kewei Xu

Calcium and CaSR/IP3R in prostate cancer development

Prostate cancer (PrCa) progression and mortality are associated with calcium metabolism, parathyroid hormone level, and vitamin D level. However, the lack of comprehensive understanding on the molecular ration...

Authors: Liyang Wang, MengMeng Xu, Zhongguang Li, Mengting Shi, Xin Zhou, Xinnong Jiang, Joseph Bryant, Steven Balk, Jianjie Ma, William Isaacs and Xuehong Xu

Long non-coding RNA CASC2 improved acute lung injury by regulating miR-144-3p/AQP1 axis to reduce lung epithelial cell apoptosis

Apoptosis of lung epithelial cell is implicated in the pathogenesis of acute lung injury (ALI). To study the protective effect and mechanism of cancer susceptibility candidate 2 (CASC2) on reducing lung epithe...

Authors: Hongbin Li, Huijuan Shi, Min Gao, Ning Ma and Rongqing Sun

Correlation between hepatic human males absent on the first (hMOF) and viral persistence in chronic hepatitis B patients

Chronic hepatitis B (CHB) remains a global health dilemma with high morbidity and mortality. Human males absent on the first (hMOF) (a histone acetyltransferase) is responsible for DNA damage repair, tumorigen...

Authors: Liwen Chen, Chuanwu Zhu, Fengdi Li, Yun Wang, Rebecca Bao, Zhujun Cao, Xiaogang Xiang, Lei Yan, Lanyi Lin, Gangde Zhao, Qing Xie, Shisan Bao and Hui Wang

Dimerized translationally controlled tumor protein increases interleukin-8 expression through MAPK and NF-κB pathways in a human bronchial epithelial cell line

Histamine releasing factor (HRF) is a unique cytokine known to regulate a variety of immune cells in late allergic reactions. In the previous study, we revealed that the biologically active form of HRF is the ...

Authors: Heewon Lee and Kyunglim Lee

Ligase IV inhibitor SCR7 enhances gene editing directed by CRISPR–Cas9 and ssODN in human cancer cells

Precise genome editing is essential for both basic and translational research. The recently developed CRISPR/Cas9 system can specifically cleave a designated site of target gene to create a DNA double-strand b...

Authors: Zheng Hu, Zhaoying Shi, Xiaogang Guo, Baishan Jiang, Guo Wang, Dixian Luo, Yonglong Chen and Yuan-Shan Zhu

Hypoxia-induced the upregulation of stromal cell-derived factor 1 in fibroblast-like synoviocytes contributes to migration of monocytes into synovium tissue in rheumatoid arthritis

Rheumatoid arthritis (RA) is an auto-immune disease characterized by chronic inflammation of multiple joints. Hypoxia is a constant feature of synovial microenvironment in RA. Fibroblast-like synoviocytes (FLS...

Authors: Ru Yang, Yanhua Yao and Panjun Wang

Function of aquaporins in sepsis: a systematic review

Sepsis is a common cause of death in intensive care units worldwide. Due to the high complexity of this immunological syndrome development of novel therapeutic strategies is urgent. Promising drug targets or b...

Authors: Katharina Rump and Michael Adamzik

Down-regulation of miR-210-3p encourages chemotherapy resistance of renal cell carcinoma via modulating ABCC1

ATP-binding cassette transporter super-family including ABCC1 and MDR-1 were involved in multi-drug resistance (MDR) of renal cell carcinoma (RCC) patients. Several miRNAs were confirmed to promote the MDR and...

Authors: Songchao Li, Jinjian Yang, Jun Wang, Wansheng Gao, Yafei Ding, Yinghui Ding and Zhankui Jia

Insights into the roles of lncRNAs in skeletal and dental diseases

Long noncoding RNAs (lncRNAs) are a class of non-protein-coding transcripts with the length longer than 200 nucleotides. Growing evidence suggests that lncRNAs, which were initially thought to be merely transc...

Authors: Yuyu Li, Jiawei Zhang, Jie Pan, Xu Feng, Peipei Duan, Xing Yin, Yang Xu, Xin Wang and Shujuan Zou

Knockdown of LncRNA MAPT-AS1 inhibites proliferation and migration and sensitizes cancer cells to paclitaxel by regulating MAPT expression in ER-negative breast cancers

MAPT-AS1, a long non-coding RNA, has not been reported in any previous research about its function in cancers. In this study, we investigated the role of MAPT-AS1 in the progression and paclitaxel resistance i...

Authors: Yiyuan Pan, Yiqi Pan, Yue Cheng, Fan Yang, Zhihan Yao and Ouchen Wang

There are only four basic modes of cell death, although there are many ad-hoc variants adapted to different situations

There have been enough cell death modes delineated in the biomedical literature to befuddle all cell death researchers. Mulling over cell death from the viewpoints of the host tissue or organ and of the host a...

Authors: Xingde Liu, Wenxiu Yang, Zhizhong Guan, Wenfeng Yu, Bin Fan, Ningzhi Xu and D. Joshua Liao

PML: Regulation and multifaceted function beyond tumor suppression

Promyelocytic leukemia protein (PML) was originally identified as a fusion partner of retinoic acid receptor alpha in acute promyelocytic leukemia patients with the (15;17) chromosomal translocation, giving ri...

Authors: Kuo-Sheng Hsu and Hung-Ying Kao

miR-26a inhibits atherosclerosis progression by targeting TRPC3

Atherosclerosis, a chronic multi-factorial vascular disease, has become a predominant cause of a variety of cardiovascular disorders. miR-26a was previously reported to be involved in atherosclerosis progressi...

Authors: Min Feng, Daqian Xu and Lirui Wang

Epigenetic alterations in TRAMP mice: epigenome DNA methylation profiling using MeDIP-seq

We investigated the genomic DNA methylation profile of prostate cancer in transgenic adenocarcinoma of the mouse prostate (TRAMP) cancer model and to analyze the crosstalk among targeted genes and the related ...

Authors: Wenji Li, Ying Huang, Davit Sargsyan, Tin Oo Khor, Yue Guo, Limin Shu, Anne Yuqing Yang, Chengyue Zhang, Ximena Paredes-Gonzalez, Michael Verzi, Ronald P. Hart and Ah-Ng Kong

Characterization and selective incorporation of small non-coding RNAs in non-small cell lung cancer extracellular vesicles

Extracellular vesicles (EVs) play important roles in intercellular communication through the delivery of their cargoes, which include proteins, lipids, and RNAs. Increasingly, multiple studies have reported th...

Authors: Chuang Li, Fang Qin, Fen Hu, Hui Xu, Guihong Sun, Guang Han, Tao Wang and Mingxiong Guo

Aspirin inhibited the metastasis of colon cancer cells by inhibiting the expression of toll-like receptor 4

The metastasis of colorectal cancer frequently tends to liver, which is one of the three leading causes of cancer-related deaths worldwide. Growing evidence showed that aspirin could effectively inhibit liver ...

Authors: Jun Ying, Hai-yang Zhou, Peng Liu, Qing You, Fei Kuang, Yi-nan Shen and Zhi-qian Hu

Hypoxic 3D in vitro culture models reveal distinct resistance processes to TKIs in renal cancer cells

The aim of this study is to determine the effect of hypoxia on axitinib and sorafenib-treated renal cell carcinoma (RCC) cells. Hypoxia is a crucial factor influencing transcription process via protein modulat...

Authors: Zofia F. Bielecka, Agata Malinowska, Klaudia K. Brodaczewska, Aleksandra Klemba, Claudine Kieda, Paweł Krasowski, Elżbieta Grzesiuk, Jan Piwowarski, Anna M. Czarnecka and Cezary Szczylik

Heart regeneration in adult Xenopus tropicalis after apical resection

Myocardium regeneration in adult mammals is very limited, but has enormous therapeutic potentials. However, we are far from complete understanding the cellular and molecular mechanisms by which heart tissue ca...

Authors: Souqi Liao, Wenyan Dong, Luocheng Lv, Hongyan Guo, Jifeng Yang, Hui Zhao, Ruijin Huang, Ziqiang Yuan, Yilin Chen, Shanshan Feng, Xin Zheng, Junqi Huang, Weihuan Huang, Xufeng Qi and Dongqing Cai

The lncRNA MEG3 downregulation leads to osteoarthritis progression via miR-16/SMAD7 axis

Osteoarthritis (OA) is a chronic joint disease and there is no a definitive cure at present. Long non-coding RNAs (lncRNAs) have been confirmed to play important roles in the development of OA. However, the un...

Authors: Jin Xu and Yaozeng Xu

miR-124 promotes proliferation and differentiation of neuronal stem cells through inactivating Notch pathway

Neural stem cells (NSCs) are able to differentiate into neurons and astroglia. miRNAs have been demonstrated to be involved in NSC self-renewal, proliferation and differentiation. However, the exact role of mi...

Authors: Shujie Jiao, Yaling Liu, Yaobing Yao and Junfang Teng

Exogenous H₂S restores ischemic post-conditioning-induced cardioprotection through inhibiting endoplasmic reticulum stress in the aged cardiomyocytes

A gasotransmitter hydrogen sulfide (H₂S) plays an important physiological and pathological role in cardiovascular system. Ischemic post-conditioning (PC) provides cardioprotection in the young hearts but not in t...

Authors: Weiming Sun, Jinxia Yang, Yuanzhou Zhang, Yuxin Xi, Xin Wen, Di Yuan, Yuehong Wang, Can Wei, Rui Wang, Lingyun Wu, Hongzhu Li and Changqing Xu