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  1. The PI3 K/AKT/mTOR signalling pathway plays an important role in the regulation of signal transduction and biological processes such as cell proliferation, apoptosis, metabolism and angiogenesis. Compared with...

    Authors: Fei Xu, Lixin Na, Yanfei Li and Linjun Chen
    Citation: Cell & Bioscience 2020 10:54

    The Retraction Note to this article has been published in Cell & Bioscience 2021 11:157

  2. Exocytosis is a process by which vesicles are transported to and fused with specific areas of the plasma membrane. Although several studies have shown that sphingolipids are the main components of exocytic com...

    Authors: Qingguo Guo, Tianrui Zhang, Na Meng, Yuran Duan, Yuan Meng, Dong Sun, Ying Liu and Guangzuo Luo
    Citation: Cell & Bioscience 2020 10:53
  3. Thanks to the advancement in science and technology and a significant number of cancer research programs being carried out throughout the world, the prevention, prognosis and treatment of breast cancer are imp...

    Authors: Debparna Nandy, Sruthy Manuraj Rajam and Debasree Dutta
    Citation: Cell & Bioscience 2020 10:52
  4. Fndc5, a well-defined myokine and also identified as an adipokine, has a critical role in modulation of metabolism and protection against obesity. These important functions are mediated by irisin, a secretory ...

    Authors: Farzaneh Rabiee, Liana Lachinani, Sarvenaz Ghaedi, Mohammad Hossein Nasr-Esfahani, Timothy L. Megraw and Kamran Ghaedi
    Citation: Cell & Bioscience 2020 10:51
  5. OTUB1 (ovarian tumor domain protease domain-containing ubiquitin aldehyde-binding proteins)-mediated deubiquitination of FOXM1 (Forkhead box M1) participates in carcinogenesis of various tumors. We aim to inve...

    Authors: Kai Zhou, Haixing Mai, Song Zheng, Weizhong Cai, Xu Yang, Zhenlin Chen and Bin Zhan
    Citation: Cell & Bioscience 2020 10:50
  6. Switching microglial polarization from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype represents a novel therapeutic strategy for neuropathic pain (NP). This study aims to investigate ...

    Authors: Xianwei Gui, Hansen Wang, Lanxiang Wu, Sheng Tian, Xuan Wang, Heqing Zheng and Wei Wu
    Citation: Cell & Bioscience 2020 10:45
  7. Induction of biliary epithelial cell apoptosis by toxic bile acids is involved in the development of cholestatic disease, but the underlying molecular mechanism is not clear. The purpose of this study was to i...

    Authors: Jiye Li, Dongsheng Yu, Sanyang Chen, Yifan Liu, Jihua Shi, Jiakai Zhang, Peihao Wen, Zhihui Wang, Jie Li, Wenzhi Guo and Shuijun Zhang
    Citation: Cell & Bioscience 2020 10:43
  8. Microglia-mediated neuroinflammation is associated with epilepsy. Switching microglial polarization from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype represents a novel therapeutic s...

    Authors: Lin Liu, Yingtong Xu, Hongmei Dai, Shan Tan, Xiao Mao and Zhiheng Chen
    Citation: Cell & Bioscience 2020 10:42
  9. Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an ongoing global health emergency. Here we highlight nine most important research questions concer...

    Authors: Kit-San Yuen, Zi -Wei Ye, Sin-Yee Fung, Chi-Ping Chan and Dong-Yan Jin
    Citation: Cell & Bioscience 2020 10:40
  10. Fanconi anemia (FA) is a recessive genetic disorder caused by biallelic mutations in at least one of 22 FA genes. Beyond its pathological presentation of bone marrow failure and congenital abnormalities, FA is...

    Authors: Wenjun Liu, Anna Palovcak, Fang Li, Alyan Zafar, Fenghua Yuan and Yanbin Zhang
    Citation: Cell & Bioscience 2020 10:39
  11. Kawasaki disease (KD) is one of the major causes of heart disease and vasculitis in children under 5 years old in the world. Clinical evidence has shown that coronary artery calcification may develop in KD pat...

    Authors: Shun-Fu Chang, Shih-Feng Liu, Cheng-Nan Chen and Ho-Chang Kuo
    Citation: Cell & Bioscience 2020 10:36
  12. Poly(ADP-ribose) polymerase (PARP) inhibitors represent one of the successful novel approaches to targeted cancer treatment. Indeed, the US Food and Drug Administration (FDA) has recently approved PARP inhibit...

    Authors: Mausam Patel, Somaira Nowsheen, Sanjay Maraboyina and Fen Xia
    Citation: Cell & Bioscience 2020 10:35
  13. The discovery of novel biomarkers of stroke etiology would be most helpful in management of acute ischemic stroke patients. Recently, circular RNAs (circRNAs) have been proposed as candidate biomarkers of neur...

    Authors: Aiora Ostolaza, Idoia Blanco-Luquin, Amaya Urdánoz-Casado, Idoya Rubio, Alberto Labarga, Beatriz Zandio, Miren Roldán, Judith Martínez-Cascales, Sergio Mayor, María Herrera, Nuria Aymerich, Jaime Gallego, Roberto Muñoz and Maite Mendioroz
    Citation: Cell & Bioscience 2020 10:34
  14. Ovarian cancer is known as a serious malignancy that affects women’s reproductive tract and can considerably threat their health. A wide range of molecular mechanisms and genetic modifications have been involv...

    Authors: Asma Vafadar, Zahra Shabaninejad, Ahmad Movahedpour, Farzaneh Fallahi, Mona Taghavipour, Younes Ghasemi, Maryam Akbari, Alimohammad Shafiee, Sarah Hajighadimi, Sanaz Moradizarmehri, Ebrahim Razi, Amir Savardashtaki and Hamed Mirzaei
    Citation: Cell & Bioscience 2020 10:32
  15. Common fragile sites (CFSs) are large chromosomal regions that exhibit breakage on metaphase chromosomes upon replication stress. They become preferentially unstable at the early stage of cancer development an...

    Authors: Shibo Li and Xiaohua Wu
    Citation: Cell & Bioscience 2020 10:29
  16. The increasing prevalence of depression and diabetes mellitus has become a major public health problem worldwide. Studies have shown that people with diabetes are at a high risk of being diagnosed with depress...

    Authors: Danwen Wang, Hui Wang, Haixia Gao, Heng Zhang, Hua Zhang, Qiuling Wang and Zhiling Sun
    Citation: Cell & Bioscience 2020 10:28
  17. Glutamate (Glu) is the predominant excitatory neurotransmitter in the central nervous system (CNS). Glutamatergic transmission is critical for controlling neuronal activity. In presynaptic neurons, Glu is stor...

    Authors: Xianchao Du, Jiashuo Li, Minghui Li, Xinxin Yang, Zhipeng Qi, Bin Xu, Wei Liu, Zhaofa Xu and Yu Deng
    Citation: Cell & Bioscience 2020 10:26
  18. Persistent infection with hepatitis B virus (HBV) accounts for the majority of hepatocellular carcinoma (HCC), but the molecular mechanisms underlying liver carcinogenesis are still not completely understood. ...

    Authors: Xiaoming Dai, Ruixue Huang, Sai Hu, Yao Zhou, Xiaoya Sun, Pucheng Gui, Zijian Yu and Pingkun Zhou
    Citation: Cell & Bioscience 2020 10:24
  19. Mesenchymal stem cells (MSCs) have been extensively studied and implicated for the cell-based therapy in several diseases due to theirs immunomodulatory properties. Embryonic stem cells and induced-pluripotent...

    Authors: Shyam Kishor Sah, Gaurav Agrahari and Tae-Yoon Kim
    Citation: Cell & Bioscience 2020 10:22
  20. Cardiovascular diseases are currently the leading cause of death in humans. The high mortality of cardiac diseases is associated with myocardial ischemia and reperfusion (I/R). Recent studies have reported tha...

    Authors: Bifeng Yao, Xiaoya Wan, Xinbin Zheng, Ting Zhong, Jia Hu, Yu Zhou, Anna Qin, Yeshuo Ma and Deling Yin
    Citation: Cell & Bioscience 2020 10:20
  21. KIT mutations are the predominant driver mutations in gastrointestinal stromal tumors (GISTs), and targeted therapy against KIT has improved treatment outcome dramatically. However, gaining secondary mutation ...

    Authors: Guangrong Zhu, Jun Shi, Shaoting Zhang, Yue Guo, Ling Huang, Hui Zhao, Yideng Jiang and Jianmin Sun
    Citation: Cell & Bioscience 2020 10:16
  22. γδ T cells are an important subset of T lymphocytes that play important roles in innate and adaptive immunity via the secretion of various cytokines. Previous studies have found that long noncoding RNAs (lncRN...

    Authors: Chuan Yang, Ting Feng, Fang Lin, Tinxiang Gong, Shuo Yang, Yuhong Tao and Hong Li
    Citation: Cell & Bioscience 2020 10:15
  23. MicroRNAs or miRNAs are a component of the non-coding RNAs family which is engaged in many cellular functions such as cell proliferation, apoptosis, gene expression, signaling pathways, angiogenesis, and etc. ...

    Authors: Mona Taghavipour, Fatemeh Sadoughi, Hamed Mirzaei, Bahman Yousefi, Bahram Moazzami, Shahla Chaichian, Mohammad Ali Mansournia and Zatollah Asemi
    Citation: Cell & Bioscience 2020 10:12
  24. Mesenchymal stem cells (MSCs) are considered the most promising seed cells for regenerative medicine because of their considerable therapeutic properties and accessibility. Fine-tuning of cell biological proce...

    Authors: Jianhan Ren, Delan Huang, Runze Li, Weicai Wang and Chen Zhou
    Citation: Cell & Bioscience 2020 10:11
  25. Histone marks control many cellular processes including DNA damage repair. This review will focus primarily on the active histone mark H3K36me3 in the regulation of DNA damage repair and the maintenance of gen...

    Authors: Zhongxing Sun, Yanjun Zhang, Junqi Jia, Yuan Fang, Yin Tang, Hongfei Wu and Dong Fang
    Citation: Cell & Bioscience 2020 10:9
  26. Poly(ADP-ribosyl)ation (PARylation) mediated by poly ADP-ribose polymerases (PARPs) plays a key role in DNA damage repair. Suppression of PARylation by PARP inhibitors impairs DNA damage repair and induces apo...

    Authors: Muzaffer Ahmad Kassab, Lily L. Yu and Xiaochun Yu
    Citation: Cell & Bioscience 2020 10:7
  27. Vascular calcification is the major reason for high mortality of cardiovascular complications for diabetes. Interleukin (IL)-1β has been implicated in this pathogenesis, but its precise role and clinical evide...

    Authors: Te-Chuan Chen, Chia-Kung Yen, Ying-Chen Lu, Chung-Sheng Shi, Rong-Ze Hsieh, Shun-Fu Chang and Cheng-Nan Chen
    Citation: Cell & Bioscience 2020 10:5
  28. Plenty of long non-coding RNAs (lncRNAs) play vital roles in the progression of atherosclerosis. Small nucleolar RNA host gene 6 (SNHG6) is a well known lncRNA that is aberrantly high expressed in atherosclero...

    Authors: Haiyan Shan, Dawei Guo, Siyang Zhang, Huimeng Qi, Shen Liu, Yanmei Du, Yini He, Bofu Wang, Ming Xu and Xiaosong Yu
    Citation: Cell & Bioscience 2020 10:4
  29. When a protein is covalently and irreversibly bound to DNA (i.e., a DNA–protein cross-link [DPC]), it may obstruct any DNA-based transaction, such as transcription and replication. DPC formation is very common...

    Authors: Huimin Zhang, Yun Xiong and Junjie Chen
    Citation: Cell & Bioscience 2020 10:3
  30. A two-stage method of obtaining viable human amniotic stem cells (hAMSCs) in large-scale is described. First, human amniotic stem cells are isolated via dual enzyme (collagenase II and DNAase I) digestion. Nex...

    Authors: Bi Foua Claude Alain Gohi, Xue-Ying Liu, Hong-Yan Zeng, Sheng Xu, Kouassi Marius Honore Ake, Xiao-Ju Cao, Kai-Min Zou and Sheila Namulondo
    Citation: Cell & Bioscience 2020 10:2
  31. miRNAs, the smallest nucleotide molecules able to regulate gene expression at post transcriptional level, are found in both animals and plants being involved in fundamental processes for growth and development...

    Authors: Bernardetta Ledda, Laura Ottaggio, Alberto Izzotti, Samir G. Sukkar and Mariangela Miele
    Citation: Cell & Bioscience 2020 10:1
  32. Breast cancer is a most common type of cancer in women. Circular RNAs (circRNAs) are involved in cancer development and progression, but their roles and regulatory mechanisms are unclear in breast cancer. Our ...

    Authors: Zhongli Geng, Wei Wang, Hui Chen, Jianya Mao, Zhenguo Li and Jing Zhou
    Citation: Cell & Bioscience 2019 9:104
  33. The failure of remodeling process that constantly regenerates effete, aged bone is highly associated with bone nonunion and degenerative bone diseases. Numerous studies have demonstrated that aspirin and other...

    Authors: Yong Xie, Meng Pan, Yanpan Gao, Licheng Zhang, Wei Ge and Peifu Tang
    Citation: Cell & Bioscience 2019 9:103
  34. Lung cancer is one of very important malignancies which are related to high mobility and mortality in the world. Despite several efforts for improving diagnosis and treatment strategies of lung cancer, finding...

    Authors: Hadis Fathizadeh and Zatollah Asemi
    Citation: Cell & Bioscience 2019 9:102