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  1. Crotonylation of proteins is a newly found type of post-translational modifications (PTMs) which occurs leadingly on the lysine residue, namely, lysine crotonylation (Kcr). Kcr is conserved and is regulated by...

    Authors: Jia-Yi Hou, Lan Zhou, Jia-Lei Li, De-Ping Wang and Ji-Min Cao
    Citation: Cell & Bioscience 2021 11:101
  2. The ongoing global pandemic of coronavirus disease 2019 (COVID-19) has resulted in the infection of over 128 million people and has caused over 2.8 million deaths as of April 2021 in more than 220 countries an...

    Authors: Brian Hetrick, Dongyang Yu, Adeyemi A. Olanrewaju, Linda D. Chilin, Sijia He, Deemah Dabbagh, Ghaliah Alluhaibi, Yuan-Chun Ma, Lewis A. Hofmann, Ramin M. Hakami and Yuntao Wu
    Citation: Cell & Bioscience 2021 11:100
  3. Endometriosis is a refractory and recurrent disease and it affects nearly 10% of reproductive-aged women and 40% of infertile patients. The commonly accepted theory for endometriosis is retrograde menstruation...

    Authors: Gen Zou, Jianzhang Wang, Xinxin Xu, Ping Xu, Libo Zhu, Qin Yu, Yangying Peng, Xinyue Guo, Tiantian Li and Xinmei Zhang
    Citation: Cell & Bioscience 2021 11:98
  4. The mechanisms leading to retinal ganglion cell (RGC) death after optic nerve injury have not been fully elucidated. Current evidence indicates that microglial activation and M1- and M2-like dynamics may be an...

    Authors: Liu Yun-Jia, Chen Xi, Zhang Jie-Qiong, Zhu Jing-Yi, Lin Sen and Ye Jian
    Citation: Cell & Bioscience 2021 11:97
  5. Poxviruses comprise many members that infect both vertebrate and invertebrate animals, including humans. Despite the eradication of the historically notorious smallpox, poxviruses remain significant public hea...

    Authors: Zhilong Yang, Mark Gray and Lake Winter
    Citation: Cell & Bioscience 2021 11:96
  6. Despite their important functions and nearly ubiquitous presence in cells, an understanding of the biology of intracellular lipid droplets (LDs) in goose follicle development remains limited. An integrated stu...

    Authors: Xin Yuan, Shenqiang Hu, Liang Li, Chunchun Han, Hehe Liu, Hua He, Lu Xia, Jiwei Hu, Bo Hu, Mingxia Ran, Yali Liu and Jiwen Wang
    Citation: Cell & Bioscience 2021 11:95
  7. The ketogenic diet (KD)has been considered an effective treatment for epilepsy, whereas its underlying mechanisms remain obscure. We have previously reported that the KD feeding increased Neuregulin 1 (NRG1) e...

    Authors: Jin Wang, Jie Huang, Shan Yao, Jia-Hui Wu, Hui-Bin Li, Feng Gao, Ying Wang, Guo-Bin Huang, Qiang-Long You, Jianhua Li, Xiaohui Chen and Xiang-Dong Sun
    Citation: Cell & Bioscience 2021 11:93
  8. Cigarette smoke (CS) exposure increases corticosteroid insensitive asthma related to increased Th17 phenotype, and new treatment strategies are needed for CS-associated asthma. Histone deacetylase 2 (HDAC2), f...

    Authors: Hongtao Li, Qimei Ye, Yusen Lin, Xuena Yang, Xiaoling Zou, Hailing Yang, Wenbin Wu, Ping Meng and Tiantuo Zhang
    Citation: Cell & Bioscience 2021 11:92
  9. The shift of oral microbiota is a critical factor of radiation caries in head and neck cancer patients after the radiotherapy. However, the direct effects of irradiation on the genome and virulence of cariogen...

    Authors: Zheng Wang, Yujie Zhou, Qi Han, Xingchen Ye, Yanyan Chen, Yan Sun, Yaqi Liu, Jing Zou, Guohai Qi, Xuedong Zhou, Lei Cheng and Biao Ren
    Citation: Cell & Bioscience 2021 11:91
  10. Iron deficiency (ID) is common in patients with heart failure (HF) and is associated with poor outcomes, yet its role in the pathophysiology of HF is not well-defined. We sought to determine the consequences o...

    Authors: M. Tajes, C. Díez-López, C. Enjuanes, P. Moliner, J. L. Ferreiro, A. Garay, S. Jiménez-Marrero, S. Yun, S. G. Sosa, L. Alcoberro, J. González-Costello, E. García-Romero, L. Yañez-Bisbe, B. Benito and J. Comín-Colet
    Citation: Cell & Bioscience 2021 11:89
  11. Bone marrow mesenchymal stem cells (BMSCs) refer to a heterogeneous population of cells with the capacity for self-renewal. BMSCs have multi-directional differentiation potential and can differentiate into cho...

    Authors: Yuanxiu Sun, Yu Yuan, Wei Wu, Le Lei and Lingli Zhang
    Citation: Cell & Bioscience 2021 11:88
  12. Mesenchymal stem cells (MSCs) play a crucial role in cancer development and tumor resistance to therapy in prostate cancer, but the influence of MSCs on the stemness potential of PCa cells by cell–cell contact...

    Authors: Ji-wen Cheng, Li-xia Duan, Yang Yu, Pu Wang, Jia-le Feng, Guan-zheng Feng and Yan Liu
    Citation: Cell & Bioscience 2021 11:87
  13. Pancreatic tumors are classified into endocrine and exocrine types, and the clinical manifestations in patients are nonspecific. Most patients, especially those with pancreatic ductal adenocarcinoma (PDAC), ha...

    Authors: Qun Chen, Wu-Jun Wang, Yun-Xuan Jia, Hao Yuan, Peng-Fei Wu, Wan-Li Ge, Ling-Dong Meng, Xu-Min Huang, Peng Shen, Tao-Yue Yang, Yi Miao, Jing-Jing Zhang and Kui-Rong Jiang
    Citation: Cell & Bioscience 2021 11:86
  14. Asthma is a heterogeneous chronic inflammatory disease of the airway, involving reversible airflow limitation and airway remodeling. T helper 17 (Th17) cells play an important role in the pathogenesis of aller...

    Authors: Jing Zhou, Ning Zhang, Wei Zhang, Caiju Lu and Fei Xu
    Citation: Cell & Bioscience 2021 11:84
  15. The Slit diaphragm (SD) is the key filtration structure in human glomerular kidney that is affected in many types of renal diseases. SD proteins are known to undergo endocytosis and recycling to maintain the i...

    Authors: Luyao Wang, Pei Wen, Joyce van de Leemput, Zhanzheng Zhao and Zhe Han
    Citation: Cell & Bioscience 2021 11:83
  16. Neovascularization is a leading cause of visual loss typically associated with diabetic retinopathy (DR) and retinopathy of prematurity (ROP). Interleukin-17A (IL-17A) and endoplasmic reticulum (ER) stress bot...

    Authors: Ya’nuo Wang, Shuang Gao, Sha Gao, Na Li, Bing Xie and Xi Shen
    Citation: Cell & Bioscience 2021 11:82
  17. Peritoneal fibrosis is one of the major complications induced by peritoneal dialysis (PD). Damaged integrity and function of peritoneum caused by peritoneal fibrosis not only limits the curative efficacy of PD...

    Authors: Yanhong Guo, Liuwei Wang, Rong Gou, Yulin Wang, Xiujie Shi, Yage Zhang, Xinxin Pang and Lin Tang
    Citation: Cell & Bioscience 2021 11:79
  18. Alzheimer’s disease (AD) is the most common cause of dementia and is characterized by the deposition of extracellular aggregates of amyloid-β (Aβ), the formation of intraneuronal tau neurofibrillary tangles an...

    Authors: Yinyin Tan, Yanqun Zheng, Daiwen Xu, Zhanfang Sun, Huan Yang and Qingqing Yin
    Citation: Cell & Bioscience 2021 11:78
  19. Hepatitis B virus (HBV) infection remains a major health issue worldwide and the leading cause of cirrhosis and hepatocellular carcinoma (HCC). It has been reported previously that HBV invasion can extensively...

    Authors: Sen Yuan, Yousaf Tanzeel, Xuezhang Tian, Dandan Zheng, Naz Wajeeha, Jiaqi Xu, Yujia Ke, Zuopeng Zhang, Xiaojun Peng, Long Lu, Guihong Sun, Deyin Guo and Min Wang
    Citation: Cell & Bioscience 2021 11:75
  20. As one of the most common malignancy, lung adenocarcinoma (LUAD) is characterized by low 5-year survival rate. This research aimed to investigate the effects of ribonucleotide reductase regulatory subunit M2 (...

    Authors: Xueping Jiang, Yangyi Li, Nannan Zhang, Yanping Gao, Linzhi Han, Shuying Li, Jiali Li, Xingyu Liu, Yan Gong and Conghua Xie
    Citation: Cell & Bioscience 2021 11:74

    The Correction to this article has been published in Cell & Bioscience 2022 12:149

  21. Dysregulation of KLF7 participates in the development of various cancers, but it is unclear whether there is a link between HCC and aberrant expression of KLF7. The aim of this study was to investigate the rol...

    Authors: Yarong Guo, Bao Chai, Junmei Jia, Mudan Yang, Yanjun Li, Rui Zhang, Shunmin Wang and Jun Xu
    Citation: Cell & Bioscience 2021 11:73
  22. As the predominant modification in RNA, N6-methyladenosine (m6A) has attracted increasing attention in the past few years since it plays vital roles in many biological processes. This chemical modification is dyn...

    Authors: Zhihao Fang, Yiqiu Hu, Jinhui Hu, Yanqin Huang, Shu Zheng and Cheng Guo
    Citation: Cell & Bioscience 2021 11:72
  23. Tissue regeneration is of fast growing importance in the development of biomedicine, particularly organ replacement therapies. Unfortunately, many human organs cannot regenerate. Anuran Xenopus laevis has been us...

    Authors: Shouhong Wang and Yun-Bo Shi
    Citation: Cell & Bioscience 2021 11:71

    The Correction to this article has been published in Cell & Bioscience 2021 11:104

  24. Epithelial to mesenchymal transition (EMT) contributes to tumor metastasis and chemoresistance. Eukaryotic initiation factor 5A2 (EIF5A2) is highly expressed in a variety of human cancers but rarely expressed ...

    Authors: Guannan Zhao, Wenjing Zhang, Peixin Dong, Hidemichi Watari, Yuqi Guo, Lawrence M. Pfeffer, Gabor Tigyi and Junming Yue
    Citation: Cell & Bioscience 2021 11:70
  25. Managing the limits of temperature adaptation is relevant both in medicine and in biotechnology. There are numerous scattered publications on the identification of the temperature limits of existence for vario...

    Authors: K. B. Aslanidi and D. P. Kharakoz
    Citation: Cell & Bioscience 2021 11:69
  26. Breast cancer (BC) remains a public-health issue on a global scale. Long non-coding RNAs (lncRNAs) play functional roles in BC. This study focuses on effects of NEAT1 on BC cell invasion, migration and chemoth...

    Authors: DaoPing Zhou, Juan Gu, YuePing Wang, HuaiGuo Wu, Wei Cheng, QingPing Wang, GuoPei Zheng and XueDong Wang
    Citation: Cell & Bioscience 2021 11:68
  27. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Haoyu Wang, Jing Yuan, Xiaoqian Dang, Zhibin Shi, Wenrui Ban and Dong Ma
    Citation: Cell & Bioscience 2021 11:67

    The original article was published in Cell & Bioscience 2021 11:52

  28. Alternative splicing (AS) regulates gene expression patterns at the post-transcriptional level and generates a striking expansion of coding capacities of genomes and cellular protein diversity. RNA splicing co...

    Authors: Yunqi Chao, Yonghui Jiang, Mianling Zhong, Kaiyan Wei, Chenxi Hu, Yifang Qin, Yiming Zuo, Lili Yang, Zheng Shen and Chaochun Zou
    Citation: Cell & Bioscience 2021 11:66
  29. Posttranscriptional gene regulation includes mRNA transport, localization, translation, and regulation of mRNA stability. CPEB (cytoplasmic polyadenylation element binding) family proteins bind to specific sites ...

    Authors: Eugene Kozlov, Yulii V. Shidlovskii, Rudolf Gilmutdinov, Paul Schedl and Mariya Zhukova
    Citation: Cell & Bioscience 2021 11:64
  30. Temozolomide (TMZ)-resistance hampers the therapeutic efficacy of this drug for glioblastoma (GBM) treatment in clinic, and emerging evidences suggested that exosomes from GBM-derived stem cells (GSCs) contrib...

    Authors: Yong Zheng, Liang Liu, Yan Wang, Shan Xiao, Rongkang Mai, Zifeng Zhu and Yiyao Cao
    Citation: Cell & Bioscience 2021 11:63
  31. Astrocytes participate in innate inflammatory responses within the mammalian central nervous system (CNS). HECT domain E3 ubiquitin protein ligase 1 (HECTD1) functions during microglial activation, suggesting ...

    Authors: Ying Tang, Mengchun Zhou, Rongrong Huang, Ling Shen, Li Yang, Zhongqiu Zhou, Hui Ren and Ying Bai
    Citation: Cell & Bioscience 2021 11:62
  32. Macrophage M1 polarization mediates inflammatory responses and tissue damage. Recently, aldose reductase (AR) has been shown to play a critical role in M1 polarization in macrophages. However, the underlying m...

    Authors: Peng Cheng, Jianwei Xie, Zhiyong Liu and Jian Wang
    Citation: Cell & Bioscience 2021 11:61

    The Correction to this article has been published in Cell & Bioscience 2021 11:135

  33. Genomic AZFb deletions in Yq11 coined “classical” (i.e. length of Y DNA deletion: 6.23 Mb) are associated with meiotic arrest (MA) of patient spermatogenesis, i.e., absence of any postmeiotic germ cells. These AZ...

    Authors: P. H. Vogt, U. Bender, B. Deibel, F. Kiesewetter, J. Zimmer and T. Strowitzki
    Citation: Cell & Bioscience 2021 11:60
  34. SARS-CoV-2 causes COVID-19 with a widely diverse disease profile that affects many different tissues. The mechanisms underlying its pathogenicity in host organisms remain unclear. Animal models for studying th...

    Authors: Jun-yi Zhu, Jin-Gu Lee, Joyce van de Leemput, Hangnoh Lee and Zhe Han
    Citation: Cell & Bioscience 2021 11:59
  35. SARS-CoV-2 causes COVID-19 which has a widely diverse disease profile. The mechanisms underlying its pathogenicity remain unclear. We set out to identify the SARS-CoV-2 pathogenic proteins that through host in...

    Authors: Jin-Gu Lee, Weiliang Huang, Hangnoh Lee, Joyce van de Leemput, Maureen A. Kane and Zhe Han
    Citation: Cell & Bioscience 2021 11:58
  36. Ewing's sarcoma is an aggressive childhood malignancy whose outcome has not substantially improved over the last two decades. In this study, combination treatments of the HSP90 inhibitor AUY922 with either the...

    Authors: Christian Marx, Marc U. Schaarschmidt, Joanna Kirkpatrick, Lisa Marx-Blümel, Melisa Halilovic, Martin Westermann, Doerte Hoelzer, Felix B. Meyer, Yibo Geng, Katrin Buder, Hauke M. Schadwinkel, Kanstantsin Siniuk, Sabine Becker, René Thierbach, James F. Beck, Jürgen Sonnemann…
    Citation: Cell & Bioscience 2021 11:57
  37. Genome editing in mice using either classical approaches like homologous recombination or CRISPR/Cas9 has been reported to harbor off target effects (insertion/deletion, frame shifts or gene segment duplicatio...

    Authors: Sabrina Sailer, Stefan Coassin, Katharina Lackner, Caroline Fischer, Eileen McNeill, Gertraud Streiter, Christian Kremser, Manuel Maglione, Catherine M. Green, Daniela Moralli, Alexander R. Moschen, Markus A. Keller, Georg Golderer, Gabriele Werner-Felmayer, Irmgard Tegeder, Keith M. Channon…
    Citation: Cell & Bioscience 2021 11:54
  38. The availability of a reliable tumor target for advanced colorectal cancer (CRC) therapeutic approaches is critical since current treatments are limited. Epidermal growth factor-like domain 6 (EGFL6) has been ...

    Authors: Ting-Yi Sung, Han-Li Huang, Chun-Chun Cheng, Fu-Ling Chang, Po-Li Wei, Ya-Wen Cheng, Cheng-Chiao Huang, Yu-Ching Lee, Wei-Chun HuangFu and Shiow-Lin Pan
    Citation: Cell & Bioscience 2021 11:53
  39. Spinal cord injury (SCI) is a disabling disorder, resulting in neurological impairments. This study investigated the mechanism of methyltransferase-like 14 (Mettl14) on apoptosis of spinal cord neurons during ...

    Authors: Haoyu Wang, Jing Yuan, Xiaoqian Dang, Zhibin Shi, Wenrui Ban and Dong Ma
    Citation: Cell & Bioscience 2021 11:52

    The Correction to this article has been published in Cell & Bioscience 2021 11:67