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  1. Content type: Research

    PDLIM2 is essential for the termination of the inflammatory transcription factors NF-κB and STAT but is dispensable for the development of immune cells and immune tissues/organs. Currently, it remains unknown ...

    Authors: Zhaoxia Qu, Jing Fu, Huihui Ma, Jingjiao Zhou, Meihua Jin, Markus Y Mapara, Michael J Grusby and Gutian Xiao

    Citation: Cell & Bioscience 2012 2:23

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  2. Content type: Research highlight

    Mutations in LMNA encoding lamins A and C are associated with at least 10 different degenerative disorders affecting diverse tissues, collectively called laminopathies. A recent study showed that mis-accumulation...

    Authors: Baohua Liu, Dong-Yan Jin and Zhongjun Zhou

    Citation: Cell & Bioscience 2012 2:21

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  3. Content type: Research

    Wounding following whole-body γ-irradiation (radiation combined injury, RCI) increases mortality. Wounding-induced increases in radiation mortality are triggered by sustained activation of inducible nitric oxi...

    Authors: Juliann G Kiang, Bradley R Garrison, True M Burns, Min Zhai, Ian C Dews, Patrick H Ney, Lynnette H Cary, Risaku Fukumoto, Thomas B Elliott and G David Ledney

    Citation: Cell & Bioscience 2012 2:20

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  4. Content type: Review

    Glucocorticoids are steroid hormones that play critical and complex roles in the regulation of triglyceride (TG) homeostasis. Depending on physiological states, glucocorticoids can modulate both TG synthesis a...

    Authors: Jen-Chywan Wang, Nora E Gray, Taiyi Kuo and Charles A Harris

    Citation: Cell & Bioscience 2012 2:19

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  5. Content type: Research

    Caenorhabditis elegans sarcomeres have been studied extensively utilizing both forward and reverse genetic techniques to provide insight into muscle development and the mechanisms behind muscle contraction. A pre...

    Authors: Qian Liu, Takako I Jones, Rebecca A Bachmann, Mitchell Meghpara, Lauren Rogowski, Benjamin D Williams and Peter L Jones

    Citation: Cell & Bioscience 2012 2:18

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  6. Content type: Review

    Cell signaling mediated by morphogens is essential to coordinate growth and patterning, two key processes that govern the formation of a complex multi-cellular organism. During growth and patterning, cells are...

    Authors: Yingzi Yang

    Citation: Cell & Bioscience 2012 2:14

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  7. Content type: Research highlight

    A novel, cancer-fighting function was recently discovered for Sm ad u biquitination r egulatory f actor 2 (Smurf2).

    Authors: Keji Zhao and Yun-Bo Shi

    Citation: Cell & Bioscience 2012 2:10

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  8. Content type: Review

    TGF-β signaling regulates diverse cellular processes, including cell proliferation, differentiation, apoptosis, cell plasticity and migration. Its dysfunctions can result in various kinds of diseases, such as ...

    Authors: Fei Huang and Ye-Guang Chen

    Citation: Cell & Bioscience 2012 2:9

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  9. Content type: Review

    Germline mutations of the BRCA1 tumor suppressor gene are a major cause of familial breast and ovarian cancer. BRCA1 plays critical roles in the DNA damage response that regulates activities of multiple repair an...

    Authors: Bin Wang

    Citation: Cell & Bioscience 2012 2:6

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  10. Content type: Review

    The structural maintenance of chromosomes (Smc) proteins regulate nearly all aspects of chromosome biology and are critical for genomic stability. In eukaryotes, six Smc proteins form three heterodimers--Smc1/...

    Authors: Nan Wu and Hongtao Yu

    Citation: Cell & Bioscience 2012 2:5

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  11. Content type: Review

    The TGFβ and Ras-MAPK pathways play critical roles in cell development and cell cycle regulation, as well as in tumor formation and metastasis. In the absence of cellular transformation, these pathways operate...

    Authors: Douglas A Chapnick, Lisa Warner, Jennifer Bernet, Timsi Rao and Xuedong Liu

    Citation: Cell & Bioscience 2011 1:42

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  12. Content type: Review

    Smad proteins are classified in different groups based on their functions in mediating transforming growth factor β (TGFβ) superfamily components. Smad1/5/8 mainly mediate bone morphogenetic proteins (BMP) pat...

    Authors: Gangwen Han and Xiao-Jing Wang

    Citation: Cell & Bioscience 2011 1:41

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  13. Content type: Research

    It remains unclear whether retroviruses can encode and express an intragenomic microRNA (miRNA). Some have suggested that processing by the Drosha and Dicer enzymes might preclude the viability of a replicatin...

    Authors: Zachary Klase, Laurent Houzet and Kuan-Teh Jeang

    Citation: Cell & Bioscience 2011 1:38

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  14. Content type: Review

    Brown adipose tissue in mammals plays a critical role in maintaining energy balance by thermogenesis, which means dissipating energy in the form of heat. It is held that in mammals, long-term surplus food inta...

    Authors: Xuan Yao, Shifang Shan, Ying Zhang and Hao Ying

    Citation: Cell & Bioscience 2011 1:35

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  15. Content type: Research

    Cancer cells possess unique metabolic phenotypes that are determined by their underlying oncogenic pathways. Activation of the PI3K/Akt/mTOR signaling cascade promotes glycolysis and leads to glucose-dependenc...

    Authors: Xiuyun Jiang, Heidi L Kenerson and Raymond S Yeung

    Citation: Cell & Bioscience 2011 1:34

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  16. Content type: Research

    Despite detailed in vivo knowledge of glycolytic enolases and many bacterial non-enolase members of the superfamily, little is known about the in vivo function of vertebrate non-enolase enolase superfamily member...

    Authors: Steve Finckbeiner, Pin-Joe Ko, Blake Carrington, Raman Sood, Kenneth Gross, Bruce Dolnick, Janice Sufrin and Paul Liu

    Citation: Cell & Bioscience 2011 1:32

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  17. Content type: Review

    Adult organ-specific stem cells are essential for organ homeostasis and repair in adult vertebrates. The intestine is one of the best-studied organs in this regard. The intestinal epithelium undergoes constant...

    Authors: Yun-Bo Shi, Takashi Hasebe, Liezhen Fu, Kenta Fujimoto and Atsuko Ishizuya-Oka

    Citation: Cell & Bioscience 2011 1:30

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  18. Content type: Review

    The epithelial to mesenchymal transition (EMT) plays crucial roles in the formation of the body plan and also in the tumor invasion process. In addition, EMT also causes disruption of cell-cell adherence, loss...

    Authors: Yingying Jing, Zhipeng Han, Shanshan Zhang, Yan Liu and Lixin Wei

    Citation: Cell & Bioscience 2011 1:29

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  19. Content type: Research

    Laribacter hongkongensis is a Gram-negative, sea gull-shaped rod associated with community-acquired gastroenteritis. The bacterium has been found in diverse freshwater environments including fish, frogs and drink...

    Authors: Susanna KP Lau, Rachel YY Fan, Gilman KM Wong, Jade LL Teng, Kong-Hung Sze, Herman Tse, Kwok-Yung Yuen and Patrick CY Woo

    Citation: Cell & Bioscience 2011 1:28

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  20. Content type: Research

    Human papillomavirus (HPV) pseudovirions have recently been shown to deliver DNA efficiently in vivo, resulting in the priming of antigen-specific CD8+ T cells in vaccinated mice. In the current study, we compare...

    Authors: Shiwen Peng, Barbara Ma, Shu-Hsia Chen, Chien-Fu Hung and TC Wu

    Citation: Cell & Bioscience 2011 1:26

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  21. Content type: Review

    The Inhibitor of Growth (ING) proteins represent a type II tumor suppressor family comprising five conserved genes, ING1 to ING5. While ING1, ING2 and ING3 proteins are stable components of the mSIN3a-HDAC comple...

    Authors: Susann Ludwig, Alexandra Klitzsch and Aria Baniahmad

    Citation: Cell & Bioscience 2011 1:25

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  22. Content type: Review

    Thyroid hormone (TH) is involved in many biological functions such as animal development, cell differentiation, etc. Variation and/or disruption of plasma TH level often led to abnormalities and physiological ...

    Authors: Shao-Chung Hsia, Gautam R Bedadala and Matthew D Balish

    Citation: Cell & Bioscience 2011 1:24

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  23. Content type: Research

    Laribacter hongkongensis is associated with community-acquired gastroenteritis and traveler's diarrhea and it can reside in human, fish, frogs and water. In this study, we performed an in-depth annotation of the ...

    Authors: Susanna KP Lau, Rachel YY Fan, Tom CC Ho, Gilman KM Wong, Alan KL Tsang, Jade LL Teng, Wenyang Chen, Rory M Watt, Shirly OT Curreem, Herman Tse, Kwok-Yung Yuen and Patrick CY Woo

    Citation: Cell & Bioscience 2011 1:22

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  24. Content type: Research

    Hemorrhage increases inducible nitric oxide synthase (iNOS) and depletes ATP levels in various tissues. Previous studies have shown that geldanamycin, an inducer of heat shock protein 70kDa (HSP-70) and inhibi...

    Authors: Juliann G Kiang, Neil G Agravante, Joan T Smith and Phillip D Bowman

    Citation: Cell & Bioscience 2011 1:21

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  25. Content type: Research

    Lithium, a drug that has long been used to treat bipolar disorder and some other human pathogenesis, has recently been shown to stimulate neural precursor growth. However, the involved mechanism is not clear. ...

    Authors: Zhaoxia Qu, Dongming Sun and Wise Young

    Citation: Cell & Bioscience 2011 1:18

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