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  1. Content type: Review

    As a hallmark of tumor cells, metabolic alterations play a critical role in tumor development and could be targeted for tumor therapy. Tumor suppressor p53 plays a central role in tumor prevention. As a transc...

    Authors: Yingjian Liang, Juan Liu and Zhaohui Feng

    Citation: Cell & Bioscience 2013 3:9

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  2. Content type: Review

    The discovery of tissue reparative and immunosuppressive abilities of mesenchymal stem cells (MSCs) has drawn more attention to tumor microenvironment and its role in providing the soil for the tumor cell grow...

    Authors: Xue Yang, Jing Hou, Zhipeng Han, Ying Wang, Chong Hao, Lixin Wei and Yufang Shi

    Citation: Cell & Bioscience 2013 3:5

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  3. Content type: Review

    TGF-β1 is an immunoregulatory cytokine that regulates immune cell proliferation, survival, differentiation, and migration. Compelling evidence has demonstrated a strong association between the immune and skele...

    Authors: Shimpei Kasagi and Wanjun Chen

    Citation: Cell & Bioscience 2013 3:4

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  4. Content type: Reviewer acknowledgement

    The editors of Cell & Bioscience would like to thank all the reviewers who contributed to the journal in Volume 2 (2012).

    Authors: Yun-Bo Shi

    Citation: Cell & Bioscience 2013 3:3

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  5. Content type: Commentary

    Following the successful cloning of receptor for SARS coronavirus a few years ago, Dr. Wenhui Li and colleagues raised attention again by publishing a possible receptor for hepatitis B virus in eLife. We will bri...

    Authors: Pei-Jer Chen and T-C Wu

    Citation: Cell & Bioscience 2013 3:2

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  6. Content type: Research

    The nucleosome remodeling and histone deacetylase complex (Mi2/NRD/NuRD/NURD) has a broad role in regulation of transcription, DNA repair and cell cycle. Previous studies have revealed a specific interaction b...

    Authors: Meng Wu, Lina Wang, Qian Li, Jiwen Li, Jun Qin and Jiemin Wong

    Citation: Cell & Bioscience 2013 3:1

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    The Erratum to this article has been published in Cell & Bioscience 2013 3:12

  7. Content type: Research

    Rheumatoid arthritis (RA) is a chronic autoimmune-disease of unknown origin that primarily affects the joints and ultimately leads to their destruction. Growing evidence suggests that synvovial fibroblasts pla...

    Authors: Daniel P Heruth, Margaret Gibson, Dmitry N Grigoryev, Li Qin Zhang and Shui Qing Ye

    Citation: Cell & Bioscience 2012 2:43

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  8. Content type: Review

    Thyroid hormone (T3) plays diverse roles in adult organ function and during vertebrate development. The most important stage of mammalian development affected by T3 is the perinatal period when plasma T3 level...

    Authors: Yun-Bo Shi, Kazuo Matsuura, Kenta Fujimoto, Luan Wen and Liezhen Fu

    Citation: Cell & Bioscience 2012 2:42

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  9. Content type: Research

    Tombusvirus P19 is a protein encoded by tomato bushy stunt virus and related tombusviruses. Earlier studies have demonstrated that P19 is an RNA silencing suppressor (RSS) in plant cells. However, it has not b...

    Authors: Xiang Liu, Laurent Houzet and Kuan-Teh Jeang

    Citation: Cell & Bioscience 2012 2:41

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  10. Content type: Research

    NF-E2-related factor 2 (NRF2) regulates a battery of antioxidative and phase II drug metabolizing/detoxifying genes through binding to the antioxidant response elements (ARE). NRF2-ARE signaling plays a central r...

    Authors: Ying Huang, Wenge Li and Ah-Ng Tony Kong

    Citation: Cell & Bioscience 2012 2:40

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  11. Content type: Research

    Toxin-antitoxin (TA) systems are commonly found in bacteria and Archaea, and it is the most common mechanism involved in bacterial programmed cell death or apoptosis. Recently, MazF, the toxin component of the...

    Authors: Xianghe Yan, Joshua B Gurtler, Pina M Fratamico, Jing Hu and Vijay K Juneja

    Citation: Cell & Bioscience 2012 2:39

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  12. Content type: Research

    Merkel cell carcinoma (MCC) is a relatively new addition to the expanding category of oncovirus-induced cancers. Although still comparably rare, the number of cases has risen dramatically in recent years. Furt...

    Authors: Bianca P Gomez, Connie Wang, Raphael P Viscidi, Shiwen Peng, Liangmei He, T-C Wu and Chien-Fu Hung

    Citation: Cell & Bioscience 2012 2:36

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  13. Content type: Editorial

    Cell and Bioscience is on track to receive its first Impact Factor in mid-2013. What is the role of the Impact Factor as a measure of a journal’s success?

    Authors: Kuan-Teh Jeang

    Citation: Cell & Bioscience 2012 2:35

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  14. Content type: Research

    After liver injury, the repair process comprises activation and proliferation of hepatic stellate cells (HSCs), which produce extracellular matrix (ECM) proteins. Peroxisome proliferator-activated receptor bet...

    Authors: Radina Kostadinova, Alexandra Montagner, Erwan Gouranton, Sébastien Fleury, Hervé Guillou, David Dombrowicz, Pierre Desreumaux and Walter Wahli

    Citation: Cell & Bioscience 2012 2:34

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  15. Content type: Review

    Nuclear receptors are a family of ligand-activated, DNA sequence-specific transcription factors that regulate various aspects of animal development, cell proliferation, differentiation, and homeostasis. The ph...

    Authors: Simran Khurana, Leslie A Bruggeman and Hung-Ying Kao

    Citation: Cell & Bioscience 2012 2:33

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  16. Content type: Review

    Golgi phosphoprotein 2 (GOLPH2, also termed GP73 and GOLM1) is a type II transmembrane protein residing in the cis and medial-Golgi cisternae. GOLPH2 is predominantly expressed in the epithelial cells of many ...

    Authors: Ha-Jeong Kim, Dandan Lv, Yan Zhang, Tao Peng and Xiaojing Ma

    Citation: Cell & Bioscience 2012 2:31

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  17. Content type: Research

    Hypoxia is associated with many disease conditions in humans, such as cancer, stroke and traumatic injuries. Hypoxia elicits broad molecular and cellular changes in diverse eukaryotes. Our recent studies sugge...

    Authors: Ranita Ghosh Dastidar, Jagmohan Hooda, Ajit Shah, Thai M Cao, Robert Michael Henke and Li Zhang

    Citation: Cell & Bioscience 2012 2:30

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  18. Content type: Review

    The Wnt signaling pathway was initially discovered for its role in tumorigenesis and the development of Drosophila and other eukaryotic organisms. The key effector of this pathway, the bipartite transcription fac...

    Authors: Wilfred Ip, Yu-ting Alex Chiang and Tianru Jin

    Citation: Cell & Bioscience 2012 2:28

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  19. Content type: Research

    During normal development primordial germ cells (PGCs) derived from the epiblast are the precursors of spermatogonia and oogonia. In culture, PGCs can be induced to dedifferentiate to pluripotent embryonic ger...

    Authors: Lu Wang, Jinping Cao, Ping Ji, Di Zhang, Lianghong Ma, Martin Dym, Zhuo Yu and Lixin Feng

    Citation: Cell & Bioscience 2012 2:27

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  20. Content type: Research

    Thyroid hormone (T3) is important for adult organ function and vertebrate development. Amphibian metamorphosis is totally dependent on T3 and offers a unique opportunity to study how T3 controls postembryonic ...

    Authors: Kazuo Matsuura, Kenta Fujimoto, Biswajit Das, Liezhen Fu, Christopher D Lu and Yun-Bo Shi

    Citation: Cell & Bioscience 2012 2:25

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  21. Content type: Review

    Phosphatases are important regulators of intracellular signaling events, and their functions have been implicated in many biological processes. Dual-specificity phosphatases (DUSPs), whose family currently con...

    Authors: Ching-Yu Huang and Tse-Hua Tan

    Citation: Cell & Bioscience 2012 2:24

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  22. Content type: Research

    PDLIM2 is essential for the termination of the inflammatory transcription factors NF-κB and STAT but is dispensable for the development of immune cells and immune tissues/organs. Currently, it remains unknown ...

    Authors: Zhaoxia Qu, Jing Fu, Huihui Ma, Jingjiao Zhou, Meihua Jin, Markus Y Mapara, Michael J Grusby and Gutian Xiao

    Citation: Cell & Bioscience 2012 2:23

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  23. Content type: Research highlight

    Mutations in LMNA encoding lamins A and C are associated with at least 10 different degenerative disorders affecting diverse tissues, collectively called laminopathies. A recent study showed that mis-accumulation...

    Authors: Baohua Liu, Dong-Yan Jin and Zhongjun Zhou

    Citation: Cell & Bioscience 2012 2:21

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  24. Content type: Research

    Wounding following whole-body γ-irradiation (radiation combined injury, RCI) increases mortality. Wounding-induced increases in radiation mortality are triggered by sustained activation of inducible nitric oxi...

    Authors: Juliann G Kiang, Bradley R Garrison, True M Burns, Min Zhai, Ian C Dews, Patrick H Ney, Lynnette H Cary, Risaku Fukumoto, Thomas B Elliott and G David Ledney

    Citation: Cell & Bioscience 2012 2:20

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  25. Content type: Review

    Glucocorticoids are steroid hormones that play critical and complex roles in the regulation of triglyceride (TG) homeostasis. Depending on physiological states, glucocorticoids can modulate both TG synthesis a...

    Authors: Jen-Chywan Wang, Nora E Gray, Taiyi Kuo and Charles A Harris

    Citation: Cell & Bioscience 2012 2:19

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  26. Content type: Research

    Caenorhabditis elegans sarcomeres have been studied extensively utilizing both forward and reverse genetic techniques to provide insight into muscle development and the mechanisms behind muscle contraction. A pre...

    Authors: Qian Liu, Takako I Jones, Rebecca A Bachmann, Mitchell Meghpara, Lauren Rogowski, Benjamin D Williams and Peter L Jones

    Citation: Cell & Bioscience 2012 2:18

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  27. Content type: Review

    Cell signaling mediated by morphogens is essential to coordinate growth and patterning, two key processes that govern the formation of a complex multi-cellular organism. During growth and patterning, cells are...

    Authors: Yingzi Yang

    Citation: Cell & Bioscience 2012 2:14

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  28. Content type: Research highlight

    A novel, cancer-fighting function was recently discovered for Sm ad u biquitination r egulatory f actor 2 (Smurf2).

    Authors: Keji Zhao and Yun-Bo Shi

    Citation: Cell & Bioscience 2012 2:10

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  29. Content type: Review

    TGF-β signaling regulates diverse cellular processes, including cell proliferation, differentiation, apoptosis, cell plasticity and migration. Its dysfunctions can result in various kinds of diseases, such as ...

    Authors: Fei Huang and Ye-Guang Chen

    Citation: Cell & Bioscience 2012 2:9

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  30. Content type: Review

    Germline mutations of the BRCA1 tumor suppressor gene are a major cause of familial breast and ovarian cancer. BRCA1 plays critical roles in the DNA damage response that regulates activities of multiple repair an...

    Authors: Bin Wang

    Citation: Cell & Bioscience 2012 2:6

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  31. Content type: Review

    The structural maintenance of chromosomes (Smc) proteins regulate nearly all aspects of chromosome biology and are critical for genomic stability. In eukaryotes, six Smc proteins form three heterodimers--Smc1/...

    Authors: Nan Wu and Hongtao Yu

    Citation: Cell & Bioscience 2012 2:5

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