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Fig. 9 | Cell & Bioscience

Fig. 9

From: Timely expression of PGAM5 and its cleavage control mitochondrial homeostasis during neurite re-growth after traumatic brain injury

Fig. 9

Elevated PGAM5 enhances mitophagy and cleaved PGAM5 promotes TFAM-mediated mitochondrial biogenesis and neurite re-growth A Expression of PGAM5 is up-regulated in injured neurons in response to TBI. Elevated PGAM5 enhances mitophagy in neurons. TBI causes loss of ΔΨm and the release of cleaved PGAM5 from mitochondria to cytosol. Cleaved PGAM5 enhances expression of TFAM and mitochondrial biogenesis followed by neurite re-growth and recovery of motor function deficit after TBI

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Cell & Bioscience

ISSN: 2045-3701

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