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Fig. 5 | Cell & Bioscience

Fig. 5

From: Timely expression of PGAM5 and its cleavage control mitochondrial homeostasis during neurite re-growth after traumatic brain injury

Fig. 5

Overexpressing full-length PGAM5 correlates with mitophagy in hippocampal neurons A Images of hippocampal neurons overexpressing PGAM5, PGAM5(Δ2-24), hPARL(AAA) or hPARL(DDD). Mitochondria and lysosomes were labeled by transient expression of MitoGFP and LysoTracker staining, respectively. Enlarged, enlarged images of the regions indicated in dashed square in the merged images. Scale bar, 20 μm (merged images) and 5 μm (enlarged images). B Quantification of co-localization% of mitochondria and lysosomes in individual hippocampal neurons. FL, full-length. WT, wild type. Dashed lines indicate the medium and dotted lines indicate the 25th and the 75th percentiles (n = 105 cells/group). **** p < 0.0001, one‑way ANOVA with Dunnett’s multiple comparisons

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