Fig. 1
From: Modulating AHR function offers exciting therapeutic potential in gut immunity and inflammation
Schematic represents canonical AHR signaling and AHR function. In the absence of ligand, AHR is retained in the cytoplasm in an inactive complex containing chaperone proteins, such as HSP90 and XAP2. Upon ligand binding, AHR translocates into the nucleus, where it dimerizes with ARNT. The AhR/ARNT dimer binds genomic regions containing DRE that regulate gene expression, further exerting a variety of functions. ARNT, AHR nuclear translocator; DRE, dioxin response element; HSP90, heat shock protein 90; XAP2, HBV X-associated protein 2; MDSC, myeloid-derived suppressor cells; Treg, regulatory T cell; T, T cells; B, B cells; NK, natural killer cell; Tr1, Type 1 regulatory T; Th17, T helper cell 17; DC, dendritic cells; ILCs, innate lymphoid cells; SC, stem cell