Fig. 6
From: Hinokitiol-iron complex is a ferroptosis inducer to inhibit triple-negative breast tumor growth
A schematic diagram that presents Fe(hino)3 -induced ferroptosis in tumors. Hino acting as an iron chelator forms a redox-active complex with iron. Upon the complex entering the cell, Fe(hino)3 (major) and released iron (minor) promote the generation of hydroxyl radicals through the Fenton reaction, resulting in the occurrence of lipid peroxidation and reduced GSH-GPX4 production, ultimately leading to ferroptosis in TNBCs