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Fig. 4 | Cell & Bioscience

Fig. 4

From: Integrated single-nucleus sequencing and spatial architecture analysis identified distinct injured-proximal tubular types in calculi rats

Fig. 4

Profiling of distinct genes in the proximal tubular cells of rats with calculi. A Heatmap of functional genes and injury markers expressed in the proximal tubular cells. B Spot plot of functional genes and injury markers expressed in the proximal tubular cells. C Representative images of immunohistochemistry staining of injury markers (Havcr1 and Spp1) in the kidney of calculi rats. D Expression profiles of distinct markers in the proximal tubular cells of rats with calculi by UMAP and column plots. The gene expression level in different groups and sub-populations were showed in different plots with error bars. *, P < 0.05, **, P < 0.001; ***, P < 0.0001; ****, P < 0.00001; ns, non-significant

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