Fig. 7

Cell–cell communications among somatic cells in the testicular microenvironment of control and disease groups. A Heatmaps of different interaction numbers (left) and strength (right) showing the comparison between disease and control groups. Red color or blue color represented upregulation or downregulation (respectively) in the disease group compared to the control group. B Network diagrams of counts of somatic cell–cell interactions in control (left) and disease (right) groups. The size of lines and numbers on lines indicated counts of interactions. Arrows reflected the direction of signals from one cell type to another. C Comparison of strength of different pathways between control and disease group. Names in red or blue indicated pathway was significant strengthened in control or disease groups, respectively (paired Wilcoxon test, p < 0.05 as significant). Names in black meant no significant difference between groups. D Chord plots reflecting CCL signal pathway networks in control (left) and disease (right) groups. E Bubble plot of detailed CCL signal pathways in cell–cell chats