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Fig. 3 | Cell & Bioscience

Fig. 3

From: Identification and validation of CCL2 as a potential biomarker relevant to mast cell infiltration in the testicular immune microenvironment of spermatogenic dysfunction

Fig. 3

External validation of CCL2 in the testing set. A Violin plot of expression level of CCL2 in control (normal spermatogenesis) and disease (spermatogenic dysfunction) groups in scRNA-seq set. Large yellow dots indicated mean expression value, **** adjust p < 0.0001 wilcoxon rank sum test with bonferroni correction using Findmarkers function. B Bar plot showing AOD of CCL2 IHC staining in control and disease groups of the testing set. **p < 0.01. C Bar plot showing CCL2 level in different testicular pathologic status. Red asterisk represents significant versus full spermatogenesis group. *p < 0.05. D Representative CCL2 IHC staining of testes with different spermatogenic status in the testing set. E Scatter plots showing spearman correlations between CCL2 expression and JS in the testing set. F Scatter plots showing spearman correlations between CCL2 expression and testicular volumes (ml) in the testing set. Note: Only 58 patients were with known testicular volumes from the ultrasound. AOD average optical density, HS hypospermatogenesis, SA spermatogenic arrest, SCOS Sertoli-cell-only syndrome

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