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Fig. 5 | Cell & Bioscience

Fig. 5

From: Genetic labeling reveals spatial and cellular expression pattern of neuregulin 1 in mouse brain

Fig. 5

Expression pattern of Nrg1 in the hippocampus. A Diagram of mouse brain sagittal section (top) and coronal section (bottom). The line in the sagittal section diagram indicates the position of the coronal section. The rectangle indicates the brain region shown in panel B. B Expression of tdTomato in the dorsal hippocampus of 2-month-old Nrg1-reporting mice. Scale bar, 300 μm. C The percentage of Nrg1-positive cells in different subregions of dorsal hippocampus among total Nrg1-positive cells. P < 0.0001, n = 3 mice (9 slices) for FC, n = 6 mice (12 slices) for other regions, one-way-ANOVA. D Expression of tdTomato in DG and CA3 region after injection of Cre-reporting AAV into the DG of 2-month-old Nrg1Cre/+ mice. Four weeks after AAV injection, the brain slices were collected and analyzed. Scale bar, 300 μm. E Fluorescent images of tdTomato and NeuN from the rectangle in panel D. Scale bar, 25 μm. F Expression of tdTomato in Sub and RS region after injection of Cre-reporting AAV into the Sub of 2-month-old Nrg1Cre/+ mice. Four weeks after AAV injection, the brain slices were collected and analyzed. Scale bar, 200 μm. G Fluorescent images of tdTomato and GABA from the rectangle in panel F. Scale bar, 25 μm. H Fluorescent images of tdTomato, NeuN and DAPI in the Sub of hippocampus. Scale bar, 25 μm. FC: fasciola cinereum; Sub: subiculum; CA1: cornu ammonis 1; CA2: cornu ammonis 2; CA3: cornu ammonis 3; DG: dentate gyrus; ml: molecular layer; gr: granular layer; pl: polymorph layer; RSA: retrosplenial agranular cortex; RSG: retrosplenial granular cortex; V2: secondary visual cortex

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