Table 1 SG-related signaling pathways in cancer
Cancer type | Downstream | Expression | Functions | References |
|---|---|---|---|---|
Breast cancer | JNK | ↓ | Inhibits apoptosis | |
|  | β-catenin | ↑ | Promotes proliferation, invasion and metastasis | |
|  | MYC | ↑ | Promotes invasion and metastasis | [92] |
|  | PMP22 | ↓ | Promotes proliferation | [93] |
|  | LINE-1 | ↑ | Promotes chemotherapeutic resistance | [94] |
|  | HIF-1α | ↑ | Promotes radiation resistance | [88] |
|  | PD-L1 | ↑ | Promotes immune escape | [95] |
|  | mTORC1 | ↓ | Inhibits apoptosis | [96] |
Cervical cancer | ROS | ↓ | Inhibits apoptosis | [97] |
|  | RBFOX2 | ↑ | Promotes proliferation | |
|  | RNH1 | ↓ | Promotes invasion and metastasis | [100] |
|  | PD-1 | ↑ | Promotes immune escape | [89] |
|  | ROS | ↓ | Promotes radiation resistance | [101] |
Lung cancer | p53 | ↓ | Inhibits apoptosis | |
|  | LET-7 | ↓ | Promotes proliferation | [83] |
|  | YWHAZ | ↑ | Inhibits apoptosis, promotes chemotherapeutic | [105] |
Gastric cancer | Â | Â | resistance | Â |
|  | TGF -β | ↑ | Promotes invasion and metastasis | [106] |
|  | β-catenin | ↑ | Inhibit apoptosis | [107] |
Colon cancer | Â | Â | Â | Â |
Pancreatic cancer | BART | ↑ | Promotes invasion and metastasis | |
Melanoma | RB1 | ↑ | Promotes invasion and metastasis | [77] |