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Fig. 7 | Cell & Bioscience

Fig. 7

From: Microglia degrade Tau oligomers deposit via purinergic P2Y12-associated podosome and filopodia formation and induce chemotaxis

Fig. 7

Microglia degrade extracellular Tau deposits by P2Y12-mediated podosome and filopodia formation. Extracellular Tau oligomers have induced Arp2 and TKS5-associated podosome clusters and filopodia formation during P2Y12-mediated microglial migration and invasion. Moreover, Tau monomer and oligomers deposits can be degraded by microglial filopodia and podosome formation. The blockage of P2Y12 signaling has reduced the microglial chemotaxis and P2Y12-associated filopodia formation and Tau-deposits degradation. Hence, P2Y12 signaling plays a dual role in extracellular Tau-induced microglial chemotaxis and the clearance of Tau deposits via podosome and filopodia-associated actin remodeling

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