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Fig. 2 | Cell & Bioscience

Fig. 2

From: Loss of Stat3 in Osterix+ cells impairs dental hard tissues development

Fig. 2

Mineralization defects in incisor enamel of Stat3 CKO mice. A Gross morphology of incisor at 3-weeks-old and 8-weeks-old. In Stat3 CKO mice, incisors exhibited rough and chalky enamel. B µCT reconstruction of Stat3 CKO mice at 8-weeks-old showed enamel mineralization defects (yellow arrow). C SEM and EDS analysis of incisors from 8-week-old mice. Compared with control mice, the enamel surface was irregular with defects in Stat3 CKO mice, and honeycomb-like micropores could be seen under high magnification. DF Quantification of Ca, P, and Ca/P ratios on the labial surfaces of mandibular incisors using energy dispersive spectroscopy. G Histological features of developing labia loops of incisor at PN5 and PN7. Developing labial loops of incisor delayed compared with control mice. The red dashed line indicated where laCL is located. Red frames and blue frames indicate the cusp areas and are close to laCL of the mandibular incisors, respectively. At higher magnification, ectopic cells appeared between ameloblasts and dentin in the incisors of Stat3 CKO mice (red arrow). Osteodentin was observed at the coronal part in Stat3 CKO mice (blue arrow). laCL labial cervical loops, Am ameloblast, Od odontoblast, P pulp, D dentin. n = 3, *P < 0.05, **P < 0.01

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