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Fig. 3 | Cell & Bioscience

Fig. 3

From: Impacts of plasma microbial lipopolysaccharide translocation on B cell perturbations and anti-CD4 autoantibody production in people with HIV on suppressive antiretroviral therapy

Fig. 3

LPS correlated with antiCD4IgG production in vivo and stimulated antiCD4IgG production by B cells in vitro. Plasma LPS levels in healthy controls and virologically suppressed PWH on ART who presented with high versus low antiCD4IgG levels were evaluated by LAL assay. (A) Plasma LPS levels in the three study groups. Correlation between antiCD4IgG and LPS levels. B cell counts (B) and proliferation (C) in response to LPS, S. aureus, P. aeruginosa, CMV, IL-23, or IL-17 in a patient-derived antiCD4IgG-producing B cell line. ANOVA and Spearman correlation tests were used to analyze data

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