Fig. 9

Schematic diagram. RNF180 increased the ubiquitin–proteasome pathway dependent degradation of RhoC. Reduced RhoC could further promote the H3K27ac enrichment on BCL6 promoter through the decrease of HDAC1, thus promoting the expression of BCL6. Then, accumlated BCL6 repressed FZD7 to inhibit Wnt/β-catenin signaling pathway and undermined the proliferation and metastasis of GC cells, meanwhile, down-regulated FZD7 induced ferroptosis through further repressed GPX4 mediated by decreased TP63