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Fig. 6 | Cell & Bioscience

Fig. 6

From: The malignancy suppression and ferroptosis facilitation of BCL6 in gastric cancer mediated by FZD7 repression are strengthened by RNF180/RhoC pathway

Fig. 6

BCL6 promotes ferroptosis of GC cells through FZD7/β-catenin/TP63-GPX4 pathway. A BCL6, FZD7, TP63, GPX4 mRNA levels in GC cells transfected with control vector or BCL6 plasmid (*P < 0.05, **p < 0.01, ***p < 0.001). B Western blot for BCL6, FZD7, β-catenin, TP63, GPX4 and β-actin in AGS and SGC-7901 cells transfected with control vector or BCL6 plasmid. C BCL6, FZD7, TP63, GPX4 mRNA levels in AGS and SGC-7901 cells transfected with control vector (Ctrl1 + Ctrl2, Ctrl1 + FZD7, BCL6 + Ctrl2) or co-transfected BCL6 plasmid and FZD7 plasmid (BCL6 + FZD7) (**p < 0.01, ***p < 0.001). D Western blot for BCL6, FZD7, β-catenin, TP63, GPX4 and β-actin in AGS and SGC-7901 cells treated as in C

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Cell & Bioscience

ISSN: 2045-3701

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