Fig. 6

Model for the H3K27me3-H3K4me1 transition in normal developmental process and PRC2-dificient mESCs. Top: During normal tissue/cell development, the H3K27me3-H3K4me1 transition regulates linage specification through the lower level of H3K4me1 unimodal reserves higher transcription level of self-tissue specific bivalent genes compared with other tissue-specific genes during development. Bottom: In Eed^−/− or Suz12^−/− mESCs, an artificial H3K27me3-H3K4me1 transition model: loss of H3K27me3 with loss of bimodal pattern of H3K4me1, was established. In this modal, genes related meso-endoderm differentiation acting as self-tissue specific genes were up-regulated owing to more loss of bimodal pattern of H3K4me1 and less decrement of LSD1 chromatin binding level at CGIs, while genes related ectoderm-differentiation acting as other tissue-specific genes were down-regulated owing to less loss of bimodal pattern of H3K4me1 and more decrement of LSD1 chromatin binding level at CGIs