Fig. 2
From: H3K27me3-H3K4me1 transition at bivalent promoters instructs lineage specification in development
Bivalent promoter CGIs undergo H3K27me3-H3K4me1 transition during development. A Heatmaps and average line plots showing H3K4me1, H3K4me3 and H3K27me3 patterns of promoter CGIs and their shores in bivalent cluster in hESC and lung. Each line represents a single CpG island. B Boxplot showing expression differences (log2FoldChange) between lung and hESC of genes in all genes (ALL) and bivalent cluster genes (Bivalent), respectively. Significance was examined with Wilcoxon rank-sum test, ****p value < 0.0001. C Average methylation patterns across CGIs and their shores of bivalent cluster in hESCs and lung. D Function enrichment analysis of all up-regulated genes between bivalent (Bivalent) and non-bivalent (non-Bivalent) genes in lung. Left panel: GO enrichment; right panel: Reactome pathway enrichment. E Heatmaps and average line plots showing H3K4me1, H3K4me3 and H3K27me3 patterns of promoter CGIs and their shores in bivalent cluster between human BJ foreskin fibroblast (hBJ)s (Fibroblast) and the iPSC cells reprogrammed from hBJ. Each line represents a single CpG island