Table 1 Clinical and pathological characteristics of patients
CLDN1 expression | < median | > median | total | p-value*** | |||
|---|---|---|---|---|---|---|---|
(n = 29) | (n = 29) | (n = 58) | |||||
N | (%) | N | (%) | N | (%) | ||
Gender | |||||||
Male | 22 | (75.9) | 13 | (44.8) | 35 | (60.3) | 0.03 |
Female | 7 | (24.1) | 16 | (55.2) | 23 | (39.7) | |
Age (years), median [63] | |||||||
≤ 63 | 11 | (38.0) | 18 | (62.1) | 29 | (50.0) | 0.07 |
> 63 | 18 | (62.0) | 11 | (37.9) | 29 | (50.0) | |
Primary tumor localization | |||||||
Right colon | 8 | (27.6) | 12 | (41.4) | 20 | (34.5) | 0.31 |
Left colon | 20 | (68.9) | 17 | (58.6) | 37 | (63.8) | |
Missing data | 1 | (3.4) | 0 | (0.0) | 1 | (1.7) | |
Differentiation | |||||||
Well | 10 | (34.5) | 8 | (27.6) | 18 | (31.0) | 0.38 |
Moderate | 15 | (51.7) | 20 | (69.0) | 35 | (60.3) | |
Missing data | 4 | (13.8) | 1 | (3.4) | 5 | (8.7) | |
Synchronous | 17 | (58.6) | 24 | (82.7) | 41 | (70.7) | 0.08 |
Metachronous | 12 | (41.4) | 5 | (17.3) | 17 | (29.3) | |
Chemotherapy regimen | |||||||
FOLFIRI | 5 | (17.3) | 8 | (27.6) | 13 | (22.4) | 0.58 |
FOLFOX | 13 | (44.8) | 10 | (34.5) | 23 | (39.7) | |
FOLFIRINOX | 11 | (37.9) | 11 | (37.9) | 22 | (37.9) | |
Targeted therapy | |||||||
YES | 6 | (20.7) | 11 | (37.9) | 17 | (29.3) | 0.15 |
NO | 23 | (79.3) | 18 | (62.1) | 41 | (70.7) | |
Number of cures, | |||||||
≤ 6 | 17 | (58.6) | 19 | (65.5) | 28 | (48.3) | 0.56 |
> 6 | 11 | (37.9) | 9 | (31.0) | 28 | (48.3) | |
Missing data | 1 | (3.5) | 1 | (3.5) | 2 | (3.4) | |
KRAS status | |||||||
WT | 7 | (24.1) | 10 | (34.5) | 17 | (29.3) | 0.74 |
Mutated | 12 | (41.4) | 14 | (48.3) | 26 | (44.8) | |
Missing data | 10 | (34.5) | 5 | (17.2) | 15 | (25.9) | |
Histological response | |||||||
Blazer score* | |||||||
1 | 18 | (62.0) | 9 | (31.0) | 27 | (46.6) | 0.029 |
2 | 10 | (34.5) | 17 | (58.6) | 27 | (46.6) | |
Missing data | 1 | (3.5) | 3 | (10.4 | 4 | (6.8) | |
TRG** | |||||||
2 | 6 | (20.7) | 1 | (3.5) | 7 | (12.0) | 0.017 |
3 | 12 | (41.3) | 5 | (17.2) | 17 | (29.3) | |
4 | 10 | (34.5) | 19 | (65.5) | 29 | (50.0) | |
5 | 0 | (0.0) | 1 | (3.5) | 1 | (1.7) | |
Missing data | 1 | (3.5) | 3 | (10.3) | 4 | (7.0) | |