Fig. 2

Exos treatment promotes better functional recovery post-injury in vivo. a BMS scores in the course of the 28-day recovery period in indicated groups. ***P < 0.001. b Evaluation of motor recovery by rotarod tests at day 28 after SCI. **P = 0.0086, ***P = 0.0008. c, d Representative images and quantification of MEP amplitude and latencies in indicated groups at day 28 post-injury. ***P < 0.001. e, f Representative immunofluorescence staining of NF in spinal cords at day 28 post-injury and quantification of NF⁺ area to the total area of uninjured axons at indicated distances from the SCI lesion core (Scale bar = 1000 μm). *P = 0.036, **P = 0.0069, ***P < 0.001. g, h Immunostaining of NeuN in spinal cords at day 28 post-injury and quantification of viable neurons in Z1–Z4 zones adjacent to lesion core (Scale bar = 1000 μm). ***P < 0.001