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Fig. 4 | Cell & Bioscience

Fig. 4

From: Overexpression of HSF2 binding protein suppresses endoplasmic reticulum stress via regulating subcellular localization of CDC73 in hepatocytes

Fig. 4

HSF2BP overexpression reduces ER stress induced by hepatic I/R. Liver is induced by 1-hour ischemia followed by 24-hour reperfusion in HSF2BP-TG and NTG mice. Sham mice received all procedures except for hepatic ischemia. A, Transmission electron microscope of liver endoplasmic reticulum (ER) after hepatic I/R in HSF2BP-TG and NTG mice. Original magnification, x1.5k and x5.0k. Western blot analysis of ER stress-related proteins (B) and their quantitative results of GRP78 (C), p-IRE1α (D), PDI (E) and CHOP (F) after hepatic I/R in HSF2BP-TG and NTG mice. Results are expressed as mean ± SE (n = 4–6/group) and compared by one-way ANOVA. * p < 0.05 versus sham mice, # p < 0.05 versus NTG mice

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Cell & Bioscience

ISSN: 2045-3701

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