Fig. 2From: The nerve growth factor-delivered signals in prostate cancer and its associated microenvironment: when the dialogue replaces the monologuePC cells are surrounded by TME cells. Epithelial PC cells (blue) release cytokines, chemokines, and growth factors. Among them, NGF promotes tumor growth and metastasis. In tumor microenvironment, CAFs release significant amounts of NGF that binds TrkA or NGFR expressed by PC cells. In such a way, stromal cells can promote cancer progression and developmentBack to article page