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Fig. 3 | Cell & Bioscience

Fig. 3

From: N-methyl-d-aspartate receptors induce M1 polarization of macrophages: Feasibility of targeted imaging in inflammatory response in vivo

Fig. 3

NMDAR increases glycolysis through intracellular calcium flux. A Effects of LPS on cytosolic Ca2+ level in BMDMs treated with BAPTA-AM or MK-801 for 24 h. B Effects of LPS, NMDA, or glutamate on cytosolic Ca2+ level in BMDMs. The cells were treated for 24 h. C Effects of NMDA, glutamate, or BAPTA-AM on the levels of the indicated proteins in BMDMs for 24 h. D Effects of BAPTA-AM on the levels of the indicated proteins in LPS-treated BMDMs for 24 h. E Effects of the calmodulin inhibitors W-7 and TFP on phosphorylated PI3K and AKT in LPS-treated BMDMs for 24 h. Data are expressed as the mean ± SD of three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.005

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