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Fig. 1 | Cell & Bioscience

Fig. 1

From: N-methyl-d-aspartate receptors induce M1 polarization of macrophages: Feasibility of targeted imaging in inflammatory response in vivo

Fig. 1

NMDAR is required for M1 macrophage polarization. A Levels of iNOS, phosphorylated p65, and NR1 in LPS-treated BMDMs for 24 h. B Relative Grin1, Grin2A, and Grin2B mRNA expression in LPS-treated BMDMs for 24 h. C Effects of LPS on the levels of p65, NR1, and iNOS in p65-silenced BMDMs. D Effects of MK-801 on the level of phosphorylated p65 in BMDMs treated with LPS for 24 h. E–G Effects of Grin1-targeting siRNA or MK-801 on iNOS (E and F) and pro-inflammatory cytokine secretion (G) in LPS-treated BMDMs for 24 h. Data are expressed as the mean ± SD of three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.0005

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