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Fig. 6 | Cell & Bioscience

Fig. 6

From: TMED3 promotes the development of malignant melanoma by targeting CDCA8 and regulating PI3K/Akt pathway

Fig. 6

TMED3 mediates melanoma development via moderating PI3K/AKT signaling pathway. A Western blotting was employed to reveal the protein expression of AKT, p-AKT, CDK1, CDK6 and PIK3CA in response to TMED3 knockdown in A375 cells. B Western blot experiment showed the changes AKT, PI3K and their phosphorylation levels in shTMED3 A375 and OM431 cells after treatment with or without SC79. C The levels of AKT, PI3K and their phosphorylation levels in A375 and OM431 cells with CDCA8 overexpression and/or TMED3 downregulation. D, E Cell proliferation (D) and apoptosis (E) in CDCA8-depleted A375 and OM431 cells were analyzed following SC79 addition. F The alterations in CDCA8, Akt, PI3K, p-Akt and p-PI3K expression in CDCA8-depleted A375 and OM431 cells following SC79 addition. The data were expressed as mean ± SD. * P < 0.05, ** P < 0.01, *** P < 0.001

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Cell & Bioscience

ISSN: 2045-3701

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