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Fig. 2 | Cell & Bioscience

Fig. 2

From: GPR116 receptor regulates the antitumor function of NK cells via Gαq/HIF1α/NF-κB signaling pathway as a potential immune checkpoint

Fig. 2

Downregulation of GPR116 receptor enhances the function of NK92 cells. A qRT-PCR analysis of the expression of GPR116 in NK92 cells after the lentivirus infection with shRNA. B The line plots displayed the cytotoxicity of NK92 cells (NC) and NK92 cells with GPR116 knockdown (SH) against K562 cells at a different effector to target (E: T) ratios for 4 h. C Flow cytometry analysis of the expression of CD107a in NK92 cells after co-incubating with K562 cells at a 5:1 ratio for 4 h. D Flow cytometry analysis of the expression of GzmB in NK92 cells after co-incubating with K562 cells at a 5:1 ratio for 4 h. E Flow cytometry analysis of the expression of IFNγ in NK92 cells after co-incubating with K562 cells at a 5:1 ratio for 4 h. Data are represented as the mean ± standard error of the mean (SEM). **P < 0.01, ***P < 0.001 by an unpaired Student’s t-test

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